Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
| العنوان: | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
|---|---|
| المؤلفون: | Luc Van Kaer, Lan Wu |
| المصدر: | Adipocyte |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | obesity, Adoptive cell transfer, Histology, Mini Review, medicine.medical_treatment, Population, chemical and pharmacologic phenomena, Inflammation, CD1d, Immune system, lipid, insulin resistance, medicine, education, education.field_of_study, diabetes, biology, ZAP70, Cell Biology, Immunotherapy, metabolic disease, Natural killer T cell, natural killer T cells, inflammation, CD1D, Immunology, biology.protein, immunotherapy, medicine.symptom |
| الوصف: | Obesity is associated with a low-grade, chronic inflammation that promotes the development of a variety of diseases, most notably type 2 diabetes. A number of cell types of the innate and adaptive immune systems have been implicated in this process. Recent studies have focused on the role of natural killer T (NKT) cells, a subset of T lymphocytes that react with lipids, in the development of obesity-associated diseases. These studies have shown that invariant NKT (iNKT) cells, a population of NKT cells expressing a semi-invariant T cell receptor, become rapidly activated in response to lipid excess, and that these cells influence the capacity of other leukocytes to produce cytokines during the progression of obesity. The role of NKT cells in obesity-associated inflammation and insulin resistance has been investigated using NKT cell-deficient animals, adoptive transfer of NKT cells and an iNKT cell agonist. While divergent results have been obtained, it is now clear that NKT cells can modulate the inflammatory milieu in obesity, suggesting that these cells could be targeted for therapeutic intervention in obesity-associated diseases. |
| تدمد: | 2162-397X 2162-3945 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939d2ec1cf9a78310f99d0118548c609Test https://doi.org/10.4161/adip.22296Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....939d2ec1cf9a78310f99d0118548c609 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2162397X 21623945 |
|---|