دورية أكاديمية
The Lipid Transfer Protein StarD7: Structure, Function, and Regulation
| العنوان: | The Lipid Transfer Protein StarD7: Structure, Function, and Regulation |
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| المؤلفون: | Susana Genti-Raimondi, Graciela M. Panzetta-Dutari, Sofía Angeletti, Viviana Rena, Jésica Flores-Martin |
| المصدر: | International Journal of Molecular Sciences, Vol 14, Iss 3, Pp 6170-6186 (2013) |
| بيانات النشر: | MDPI AG, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | StarD7, START domain, SF-1, b-catenin, ABCG2, cell migration, cell proliferation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | http://www.mdpi.com/1422-0067/14/3/6170Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms14036170 |
| الوصول الحر: | https://doaj.org/article/c8f556c55b10439286327f657f4d6b6bTest |
| رقم الانضمام: | edsdoj.8f556c55b10439286327f657f4d6b6b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms14036170 |