التفاصيل البيبلوغرافية
| العنوان: |
Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study. |
| المؤلفون: |
Sarton, Benjamine, Grare, Marion, Vardon-Bounes, Fanny, Gaubert, Anna, Silva, Stein, Crognier, Laure, Riu, Béatrice, Seguin, Thierry, Georges, Bernard, Minville, Vincent, Ruiz, Stéphanie |
| المصدر: |
Biomedicines; Aug2022, Vol. 10 Issue 8, pN.PAG-N.PAG, 13p |
| مصطلحات موضوعية: |
VENTILATOR-associated pneumonia, COVID-19, CRITICALLY ill, ARTIFICIAL respiration, MIXED infections |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Considering virus-related and drug-induced immunocompromised status of critically ill COVID-19 patients, we hypothesize that these patients would more frequently develop ventilator-associated pneumonia (VAP) than patients with ARDS from other viral causes. We conducted a retrospective observational study in two intensive care units (ICUs) from France, between 2017 and 2020. We compared bacterial co-infection at ICU admission and throughout the disease course of two retrospective longitudinally sampled groups of critically ill patients, who were admitted to ICU for either H1N1 or SARS-CoV-2 respiratory infection and depicted moderate-to-severe ARDS criteria upon admission. Sixty patients in the H1N1 group and 65 in the COVID-19 group were included in the study. Bacterial co-infection at the endotracheal intubation time was diagnosed in 33% of H1N1 and 16% COVID-19 patients (p = 0.08). The VAP incidence per 100 days of mechanical ventilation was 3.4 (2.2–5.2) in the H1N1 group and 7.2 (5.3–9.6) in the COVID-19 group (p < 0.004). The HR to develop VAP was of 2.33 (1.34–4.04) higher in the COVID-19 group (p = 0.002). Ten percent of H1N1 patients and 30% of the COVID-19 patients had a second episode of VAP (p = 0.013). COVID-19 patients have fewer bacterial co-infections upon admission, but the incidence of secondary infections increased faster in this group compared to H1N1 patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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