التفاصيل البيبلوغرافية
| العنوان: |
Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer's disease. |
| المؤلفون: |
Gouilly, Dominique, Salabert, Anne-Sophie, Bertrand, Elsa, Goubeaud, Marie, Catala, Hélène, Germain, Johanne, Ainaoui, Nadéra, Rafiq, Marie, Benaiteau, Marie, Carlier, Jasmine, Nogueira, Leonor, Planton, Mélanie, Hitzel, Anne, Méligne, Déborah, Sarton, Benjamine, Silva, Stein, Lemesle, Béatrice, Payoux, Pierre, Thalamas, Claire, Péran, Patrice |
| المصدر: |
Frontiers in Neurology; 2023, p1-8, 8p |
| مصطلحات موضوعية: |
ALZHEIMER'S disease, CEREBRAL amyloid angiopathy, CEREBELLAR cortex, POSITRON emission tomography, NEUROPSYCHOLOGICAL tests, HETEROGENEITY |
| مستخلص: |
The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer's disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multidomain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [18F]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation was heterogeneous and exhibited no correlation with cognition at voxel-wise, regional or whole-brain level. The distribution of the SUVR values was independent of sex, APOE phenotype, early and late onset of symptoms and the presence of cerebral amyloid angiopathy. However, we were able to demonstrate a complex dissociation as some patients with similar PET pattern had opposed neuropsychological profiles while other patients with opposite PET profiles had similar neuropsychological presentation. Further studies are needed to explore how this heterogeneity impacts disease progression. [ABSTRACT FROM AUTHOR] |
|
Copyright of Frontiers in Neurology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder