المؤلفون: National Heart, Lung, and Blood Institute (NHLBI)

المساهمون: John Brunzell, Professor Emeritus, Active, Medicine/Division of Metabolism

المصدر: Brunzell JD. Are all obese patnts at rk for cardvascular dease? t J Obes. 1984;8(5):571-8. No abstract avaable.
Brunzell JD, Snerman AD, Albers JJ, Kwerovh PO Jr. Apoprotes B and A-and coronary artery dease humans. Arterscleros. 1984 Mar-Apr;4(2):79-83. do 10.1161/01.atv.4.2.79. No abstract avaable.
ers PH, Brunzell JD. Human adose tsue loprote lase: changes wh feedg and relatn to posthepar plasma enzyme. Am J Physl. 1985 Jul;249(1 Pt 1):E107-14. do 10.1152/ajpendo.1985.249.1.E107.
ers PH, Brunzell JD. Chylomronem duced by cete. Gastroenterology. 1985 Sep;89(3):664-6. do 10.1016/0016-5085(85)90466-4.
ers PH, Brunzell JD. Obesy and common genet metabol dorders. Ann tern Med. 1985 Dec;103(6 ( Pt 2)):1050-1. do 10.7326/0003-4819-103-6-1050.
Foster DM, Cha A, Albers JJ, Faor RA, Harr C, Brunzell JD. Evence for ket heterogeney among human low densy loprotes. Metabolm. 1986 Aug;35(8):685-96. do 10.1016/0026-0495(86)90235-0.
Cha A, Foster DM, Albers JJ, Faor RA, Brunzell JD. Low densy loprote metabolm faml combed hyperlem and faml hypercholesterolem: ket analys usg an tegrated model. Metabolm. 1986 Aug;35(8):697-704. do 10.1016/0026-0495(86)90236-2.
Angel B, Hershon KS, Brunzell JD. Be ac metabolm heredary forms of hypertrlycerem: evence for an creased synthes rate monogen faml hypertrlycerem. Proc Natl Acad ScU S A. 1987 Aug;84(15):5434-8. do 10.1073/pnas.84.15.5434.
Auwerx JH, Deeb S, Brunzell JD, Peng R, Cha A. Transcrtnal actatn of the loprote lase and apoloprote E genes accompans dferenttn some human macrophage-le cell les. Bchemtry. 1988 Apr 19;27(8):2651-5. do 10.1021/b0408a003.
ers PH, Brunzell JD. Relatnsh between loprote lase acty and plasma sex stero level obese women. J Cl vest. 1988 Sep;82(3):1106-12. do 10.1172/JC13667.
Whe JR, Cha A, Klebanoff SJ, Deeb S, Brunzell JD. Bacterl lopolysacchare reduces macrophage loprote lase levels: an effect that dependent of tumor necros factor. J L Res. 1988 Oct;29(10):1379-85.
Auwerx JH, Marzetta CA, Hokanson JE, Brunzell JD. Large buoyant LDL-le partles hepat lase defncy. Arterscleros. 1989 May-Jun;9(3):319-25. do 10.1161/01.atv.9.3.319.
Babak SP, ers PH, Fujoto WY, Brunzell JD. Detectn and characteratn of the heterozygote state for loprote lase defncy. Arterscleros. 1989 May-Jun;9(3):326-34. do 10.1161/01.atv.9.3.326.
Auwerx JH, Deeb S, Brunzell JD, Wolfbauer G, Cha A. Loprote lase gene expressn THP-1 cells. Bchemtry. 1989 May 30;28(11):4563-7. do 10.1021/b0437a009.
Marzetta CA, Foster DM, Brunzell JD. Relatnshs between LDL densy and ket heterogeney subjects wh normolem and faml combed hyperlem usg densy gradnt ultracentrugatn. J L Res. 1989 Sep;30(9):1307-17.
Auwerx JH, Babak SP, Fujoto WY, ers PH, Brunzell JD. Defecte enzyme prote loprote lase defncy. Eur J Cl vest. 1989 Oct;19(5):433-7. do 10.1111/j.1365-2362.1989.tb00255.x.
Langlo S, Deeb S, Brunzell JD, Kastele JJ, Hayden MR. A major sertn accounts for a snant proportn of mutatns underlyg human loprote lase defncy. Proc Natl Acad ScU S A. 1989 Feb;86(3):948-52. do 10.1073/pnas.86.3.948.
Rohlfg JJ, Brunzell JD. The effects of drets and adrenerg-blockg agents on plasma ls. West J Med. 1986 Aug;145(2):210-8.
Deeb S, Faor A, Brown BG, Brunzell JD, Albers JJ, Motulsky AG. Molecular genets of apoloprotes and coronary heart dease. Cold Sprg Harb Symp Quant Bl. 1986;51 Pt 1:403-9. do 10.1101/sqb.1986.051.01.048.
Wele DS, Sande KJ, ers PH, Monsen ER, Brunzell JD. Weht loss leads to a marked decrease nonrestg energy expendure ambulatory human subjects. Metabolm. 1988 Oct;37(10):930-6. do 10.1016/0026-0495(88)90149-7.
Aust MA, Brunzell JD, Fch WL, Krauss RM. herance of low densy loprote subclass patterns faml combed hyperlem. Arterscleros. 1990 Jul-Aug;10(4):520-30. do 10.1161/01.atv.10.4.520.
Marzetta CA, Foster DM, Brunzell JD. Conversn of plasma VLDL and L precursors to varus LDL subpopulatns usg densy gradnt ultracentrugatn. J L Res. 1990 Jun;31(6):975-84.
Brunzell JD, Aust MA. dualy, hyperlem, and premature coronary artery dease. World Rev Nutr Dt. 1990;63:72-83. do 10.1159/000418499. No abstract avaable.
Auwerx JH, Babak SP, Hokanson JE, Stahnke G, Wl H, Deeb SS, Brunzell JD. Coextence of abnormals of hepat lase and loprote lase a large famy. Am J Hum Genet. 1990 Mar;46(3):470-7.
Aust MA, Wsman E, Guo SW, Krauss RM, Brunzell JD, Deeb S. Lack of evence for lkage between low-densy loprote subclass phenotypes and the apoloprote B locus faml combed hyperlem. Genet Epeml. 1991;8(5):287-97. do 10.1002/gep1370080502.
Bru T, Kastele JJ, Van Drmen DE, Ma Y, Henderson HE, Stuyt PM, Stalenhoef AF, Sturk A, Brunzell JD, Hayden MR. A msense mutatn Pro157 Arg loprote lase (LPLNmegen) resultg loss of catalyt acty. Eur J Bchem. 1992 Sep 1;208(2):267-72. do 10.1111/j.1432-1033.1992.tb17182.x.
Rea M, Brunzell JD, Deeb SS. Molecular bas of faml chylomronem: mutatns the loprote lase and apoloprote C- genes. J L Res. 1992 Dec;33(12):1823-32.
Deeb SS, Faor RA, Brown BG, Brunzell JD, Albers JJ, Motulsky AG, Wsman E. Assoctn of apoloprote B gene varnts wh plasma apoB and low densy loprote (LDL) cholesterol levels. Hum Genet. 1992 Feb;88(4):463-70. do 10.1007/BF00215683.
Emmerh J, Beg OU, Peterson J, Prevto L, Brunzell JD, Brewer HB Jr, Santamara-Fojo S. Human loprote lase. Analys of the catalyt trd by se-dected mutagenes of Ser-132, Asp-156, and H-241. J Bl Chem. 1992 Feb 25;267(6):4161-5.
Devl RH, Deeb S, Brunzell J, Hayden MR. Partl gene duplatn volvg exon-Alu terchange results loprote lase defncy. Am J Hum Genet. 1990 Jan;46(1):112-9.
Zambon A, Aust MA, Brown BG, Hokanson JE, Brunzell JD. Effect of hepat lase on LDL normal men and those wh coronary artery dease. Arterscler Thromb. 1993 Feb;13(2):147-53. do 10.1161/01.atv.13.2.147.
Joven J, Vella E, Ahmad S, Cheung MC, Brunzell JD. Loprote heterogeney end-stage renal dease. Kney t. 1993 Feb;43(2):410-8. do 10.1038/k1993.60.
Hokanson JE, Aust MA, Zambon A, Brunzell JD. Plasma trlycere and LDL heterogeney faml combed hyperlem. Arterscler Thromb. 1993 Mar;13(3):427-34. do 10.1161/01.atv.13.3.427.
Zambon A, Hashoto S Brunzell JD. Analys of technues to obta plasma for measurement of levels of free fatty acs. J L Res. 1993 Jun;34(6):1021-8.
Jarv GP, Wsman E, Ltle RE, Albers JJ, Motulsky AG, Brunzell JD. Host and envonmental effects on plasma apoloprote B. t J Cl Lab Res. 1993;23(4):215-20. do 10.1007/BF02592312.
Zambon A, Torres A, Bvoet S, Gagne C, MoorjanS, Lupn PJ, Hayden MR, Brunzell JD. Preventn of raed low-densy loprote cholesterol a patnt wh faml hypercholesterolaem and loprote lase defncy. Lancet. 1993 May 1;341(8853):1119-21. do 10.1016/0140-6736(93)93129-o.
Nev DN, Brunzell JD, Deeb SS. The LPL gene duals wh faml combed hyperlem and decreased LPL acty. Arterscler Thromb. 1994 Jun;14(6):869-73. do 10.1161/01.atv.14.6.869.
Jarv GP, Brunzell JD, Aust MA, Krauss RM, Motulsky AG, Wsman E. Genet predtors of FCHL four large pedrees. fluence of ApoB level major locus predted genotype and LDL subclass phenotype. Arterscler Thromb. 1994 Nov;14(11):1687-94. do 10.1161/01.atv.14.11.1687.
Aust MA, Hokanson JE, Brunzell JD. Characteratn of low-densy loprote subclasses: methodolog approaches and clal relevance. Curr Op Lol. 1994 Dec;5(6):395-403. do 10.1097/00041433-199412000-00002.
Hokanson JE, Krauss RM, Albers JJ, Aust MA, Brunzell JD. LDL physal and chemal properts faml combed hyperlem. Arterscler Thromb Vasc Bl. 1995 Apr;15(4):452-9. do 10.1161/01.atv.15.4.452.
Yang WS, Nev DN, Peng R, Brunzell JD, Deeb SS. A mutatn the promoter of the loprote lase (LPL) gene a patnt wh faml combed hyperlem and low LPL acty. Proc Natl Acad ScU S A. 1995 May 9;92(10):4462-6. do 10.1073/pnas.92.10.4462. Erratum : Proc Natl Acad ScU S A 1996 Jan 9;93(1):524.
Deeb SS, Nev DN, asakL, Brunzell JD. Two novel apoloprote A- varnts duals wh faml combed hyperlem and dhed levels of loprote lase acty. Hum Mutat. 1996;8(4):319-25. do 10.1002/(S1098-1004(1996)8:43.0.CO;2-2.
Yang WS, Nev DN, asakL, Peng R, Brown BG, Brunzell JD, Deeb SS. Regulatory mutatns the human loprote lase gene patnts wh faml combed hyperlem and coronary artery dease. J L Res. 1996 Dec;37(12):2627-37.
Wsman EM, Brunzell JD, Jarv GP, Aust MA, Motulsky AG, Deeb SS. Evence agast lkage of faml combed hyperlem to the apoloprote ACA gene complex. Arterscler Thromb Vasc Bl. 1998 Feb;18(2):215-26. do 10.1161/01.atv.18.2.215.
Brown BG, Zambon A, Poul D, Rocha A, Maher VM, Dav JW, Albers JJ, Brunzell JD. Use of nc, stats, and ress patnts wh combed hyperlem. Am J Cardl. 1998 Feb 26;81(4A):52B-59B.
Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mchell ES, Brunzell JD. A hepat lase gene promoter polymorphm attenuates the crease hepat lase acty wh creasg tra-abdomal fat women. Arterscler Thromb Vasc Bl. 1999 Nov;19(11):2701-7. do 10.1161/01.atv.19.11.2701.
Ullrh NF, Purnell JQ, Brunzell JD. Adose tsue fatty ac composn humans wh loprote lase defncy. J vest Med. 2001 May;49(3):273-5.
Purnell JQ, Kahn SE, Schwartz RS, Brunzell JD. Relatnsh of sul sensy and ApoB levels to tra-abdomal fat subjects wh faml combed hyperlem. Arterscler Thromb Vasc Bl. 2001 Apr;21(4):567-72. do 10.1161/01.atv.21.4.567.
Zambon A, Brown BG, Deeb SS, Brunzell JD. Hepat lase as a focal pot for the development and treatment of coronary artery dease. J vest Med. 2001 Jan;49(1):112-8. do 10.2310/6650.2001.34107.
Zambon A, Deeb SS, Brown BG, Hokanson JE, Brunzell JD. Common hepat lase gene promoter varnt determes clal response to tense l-lowerg treatment. Cculatn. 2001 Feb 13;103(6):792-8. do 10.1161/01.c.103.6.792.
Carr MC, K KH, Zambon A, Mchell ES, Woods NF, Casazza CP, Purnell JQ, Hokanson JE, Brunzell JD, Schwartz RS. Changes LDL densy across the menopausal transn. J vest Med. 2000 Jul;48(4):245-50.
Purnell JQ, Kahn SE, Albers JJ, Nev DN, Brunzell JD, Schwartz RS. Effect of weht loss wh reductn of tra-abdomal fat on l metabolm older men. J Cl Endocrol Metab. 2000 Mar;85(3):977-82. do 10.1210/jcem.85.3.6402.
Purnell JQ, Zambon A, Knopp RH, PzutDJ, AcharR, Leonard JM, Locke C, Brunzell JD. Effect of ronav on ls and post-hepar lase acts normal subjects. AS. 2000 Jan 7;14(1):51-7. do 10.1097/00002030-200001070-00006.
Murdoch SJ, Carr MC, Hokanson JE, Brunzell JD, Albers JJ. PLTP acty premenopausal women. Relatnsh wh loprote lase, HDL, LDL, body fat, and sul restance. J L Res. 2000 Feb;41(2):237-44.
Zambon A, Deeb SS, Bensadoun A, Foster KE, Brunzell JD. vo evence of a role for hepat lase human apoB-contag loprote metabolm, dependent of s lolyt acty. J L Res. 2000 Dec;41(12):2094-9.
Brunzell JD, Hokanson JE. Low-densy and hh-densy loprote subspecs and rk for premature coronary artery dease. Am J Med. 1999 Aug 23;107(2A):16S-18S. do 10.1016/s0002-9343(99)00139-4. No abstract avaable.
Zambon A, Hokanson JE, Brown BG, Brunzell JD. Evence for a new pathophyslogal mechanm for coronary artery dease regressn: hepat lase-medted changes LDL densy. Cculatn. 1999 Apr 20;99(15):1959-64. do 10.1161/01.c.99.15.1959.
Brunzell JD, Hokanson JE. Dyslem of central obesy and sul restance. Dbetes Care. 1999 Apr;22 Suppl 3:C10-3. No abstract avaable.
Hokanson JE, Brunzell JD, Jarv GP, Wsman EM, Aust MA. Lkage of low-densy loprote se to the loprote lase gene heterozygous loprote lase defncy. Am J Hum Genet. 1999 Feb;64(2):608-18. do 10.1086/302234.
Franz MJ, Bantle JP, Beebe CA, Brunzell JD, Chsson JL, Garg A, Holzmeter LA, Hoogwerf B, Mayer-Dav E, Mooradn AD, Purnell JQ, Wheeler M. Evence-based nutrn prcles and recommendatns for the treatment and preventn of dbetes and related complatns. Dbetes Care. 2002 Jan;25(1):148-98. do 10.2337/dcare.25.1.148. No abstract avaable.
Love MW, Craddock AL, Angel B, Brunzell JD, Duane WC, Dawson PA. Analys of the eal be ac transporter gene, SLC10A2, subjects wh faml hypertrlycerem. Arterscler Thromb Vasc Bl. 2001 Dec;21(12):2039-45. do 10.1161/hq1201.100262.
McNeely MJ, Edwards KL, Marcova SM, Brunzell JD, Motulsky AG, Aust MA. Loprote and apoloprote abnormals faml combed hyperlem: a 20-year prospecte study. Atheroscleros. 2001 Dec;159(2):471-81. do 10.1016/s0021-9150(01)00528-7.
Carr MC, Hokanson JE, Zambon A, Deeb SS, Barrett PH, Purnell JQ, Brunzell JD. The contrutn of traabdomal fat to gender dferences hepat lase acty and low/hh densy loprote heterogeney. J Cl Endocrol Metab. 2001 Jun;86(6):2831-7. do 10.1210/jcem.86.6.7586.
Carr MC, Brunzell JD. Abdomal obesy and dyslem the metabol syndrome: portance of type 2 dbetes and faml combed hyperlem coronary artery dease rk. J Cl Endocrol Metab. 2004 Jun;89(6):2601-7. do 10.1210/jc.2004-0432.
Brunzell JD, ers PH, Scheel MS, Fujoto WY, Hayden MR, McLeod R, Frolh J. Prary loprote lase defncy. Adv Exp Med Bl. 1986;201:227-39. do 10.1007/978-1-4684-1262-8_20.
Brunzell JD, Fujoto WY. Body fat dtrutn and dyslem. Am J Med. 1995 Nov;99(5):457-8. do 10.1016/s0002-9343(99)80219-8. No abstract avaable.
Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00005313Test

المؤلفون: National Heart, Lung, and Blood Institute (NHLBI)

المصدر: Jarv GP, Brunzell JD, Aust MA, Krauss RM, Motulsky AG, Wsman E. Genet predtors of FCHL four large pedrees. fluence of ApoB level major locus predted genotype and LDL subclass phenotype. Arterscler Thromb. 1994 Nov;14(11):1687-94. do 10.1161/01.atv.14.11.1687.
Hokanson JE, Aust MA. Plasma trlycere level a rk factor for cardvascular dease dependent of hh-densy loprote cholesterol level: a meta-analys of populatn-based prospecte studs. J Cardvasc Rk. 1996 Apr;3(2):213-9.
Aust MA, Edwards KL. Small, dense low densy loprotes, the sul restance syndrome and nonsul-dependent dbetes. Curr Op Lol. 1996 Jun;7(3):167-71. do 10.1097/00041433-199606000-00010.
Aust MA, Hokanson JE, Brunzell JD. Characteratn of low-densy loprote subclasses: methodolog approaches and clal relevance. Curr Op Lol. 1994 Dec;5(6):395-403. do 10.1097/00041433-199412000-00002.
Aust MA. Small, dense low-densy loprote as a rk factor for coronary heart dease. t J Cl Lab Res. 1994;24(4):187-92. do 10.1007/BF02592460.
Edwards KL, Mahaney MC, Motulsky AG, Aust MA. Pletrop genet effects on LDL se, plasma trlycere, and HDL cholesterol fams. Arterscler Thromb Vasc Bl. 1999 Oct;19(10):2456-64. do 10.1161/01.atv.19.10.2456.
Aust MA, McKnht B, Edwards KL, Bradley CM, McNeely MJ, Psaty BM, Brunzell JD, Motulsky AG. Cardvascular dease mortaly faml forms of hypertrlycerem: A 20-year prospecte study. Cculatn. 2000 Jun 20;101(24):2777-82. do 10.1161/01.c.101.24.2777.
Aust MA. Trlycere, small, dense low-densy loprote, and the atherogen loprote phenotype. Curr Atheroscler Rep. 2000 May;2(3):200-7. do 10.1007/s11883-000-0021-4.
Aust MA, Zmern RL, Humphrs SE. Hh "populatn attrutable fractn" for coronary heart dease mortaly among relates monogen faml hypercholesterolem. Genet Med. 2002 Jul-Aug;4(4):275-8. do 10.1097/00125817-200207000-00005.
McNeely MJ, Edwards KL, Marcova SM, Brunzell JD, Motulsky AG, Aust MA. Loprote and apoloprote abnormals faml combed hyperlem: a 20-year prospecte study. Atheroscleros. 2001 Dec;159(2):471-81. do 10.1016/s0021-9150(01)00528-7.
K H, Marcova SM, Edwards KL, McKnht B, Bradley CM, McNeely MJ, Psaty BM, Motulsky AG, Aust MA. Loprote(a) as a rk factor for maternal cardvascular dease mortaly kdreds wh faml combed hyperlem or faml hypertrlycerem. Cl Genet. 2001 Sep;60(3):188-97. do 10.1034/j.1399-0004.2001.600304.x.
KamakAS, Scovk DS, Schwartz SM, Psaty BM, Edwards KL, Raghunathan TE, Aust MA. Low densy loprote partle se and rk of early-onset myocardl farctn women. Am J Epeml. 2001 May 15;153(10):939-45. do 10.1093/aje/153.10.939.
Aust MA, Edwards KL, Monks SA, Koprowz KM, Brunzell JD, Motulsky AG, Mahaney MC, Hson JE. Genome-we scan for quantate tra locfluencg LDL se and plasma trlycere faml hypertrlycerem. J L Res. 2003 Nov;44(11):2161-8. do 10.1194/jlr.M300272-JLR200. Epub 2003 Aug 16.
AyyobAF, McGladdery SH, McNeely MJ, Aust MA, Motulsky AG, Brunzell JD. Small, dense LDL and elevated apoloprote B are the common characterts for the three major l phenotypes of faml combed hyperlem. Arterscler Thromb Vasc Bl. 2003 Jul 1;23(7):1289-94. do 10.1161/01.ATV.0000077220.44620.9B. Epub 2003 May 15.
Hutter CM, Aust MA, Humphrs SE. Faml hypercholesterolem, perheral arterl dease, and stroke: a HuGE mevw. Am J Epeml. 2004 Sep 1;160(5):430-5. do 10.1093/aje/kwh238.
Aust MA, Hutter CM, Zmern RL, Humphrs SE. Faml hypercholesterolem and coronary heart dease: a HuGE assoctn revw. Am J Epeml. 2004 Sep 1;160(5):421-9. do 10.1093/aje/kwh237.
Aust MA, Hutter CM, Zmern RL, Humphrs SE. Genet causes of monogen heterozygous faml hypercholesterolem: a HuGE prevalence revw. Am J Epeml. 2004 Sep 1;160(5):407-20. do 10.1093/aje/kwh236.

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00005368Test

المؤلفون: National Heart, Lung, and Blood Institute (NHLBI)

المصدر: Genomic Dissection of a QTL Affecting the Lipid Profile

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00064688Test

المؤلفون: National Heart, Lung, and Blood Institute (NHLBI)

المساهمون: Paivi Pajukanta, Professor

المصدر: Genetic Susceptibility to Common Lipid Disorders in Mexico

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00365235Test

المصدر: Effects of Activation of the Farnesoid X Receptor (FXR) on Hepatic Lipid and Glucose Metabolism in Patients With the Metabolic Syndrome and Familial Forms of Hypertriglyceridemia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00465751Test

المساهمون: Senior Director, Metabolic Medical Research

المصدر: The Effects of the Combination of Welchol and Tricor Compared to TriCor Alone in Patients With Mixed Hyperlipidemia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00754039Test

المصدر: Efficacy and Safety of Co-administration of Omacor Plus Atorvastatin Compared With Atorvastatin Monotherapy in Patients With Type Ⅱb Dyslipidemia: a Multicenter, Double-blind, Randomized, Active-controlled, Parallel, Phase Ⅲ Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT02035215Test

المساهمون: M.A. de Vries, MD

المصدر: Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT02130505Test

المصدر: A Randomized, Double-blind, Multicenter, Placebo-controlled Clinical Trial of Safety and Efficacy of "Phospholipovit" in Patients With Combined Hyperlipidemia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05742022Test

المصدر: A Randomized, Double-blind, Placebo-controlled Phase III Clinical Study Evaluating the Efficacy and Safety of JS002 Prefilled Syringes(PFS) and Prefilled Autosyringes(AI) in Patients With Primary Hypercholesterolemia and Mixed Hyperlipidemia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05532800Test