المؤلفون: LAT Research, Xolomon Tree S.L.

المصدر: Mallg HJ. The posn of munotherapy the European Academy of Allergology and Clal munology. J vest Allergol Cl munol. 1997 Sep-Oct;7(5):356-7. No abstract avaable.
Svent S, Sor CauquC, Cases B, Manzano A Dz-Rero CM, Reche PA, Lopez-Relano J, Martez-Naves E, Canada FJ, Jenez-Barbero J, Suba J, Casanovas M, Fernandez-Caldas E, Suba JL, Palomares O. Novel vacces targetg dendr cells by couplg allergos to nonoxed mannan enhance allergen uptake and duce functnal regulatory T cells through programmed death land 1. J Allergy Cl munol. 2016 Aug;138(2):558-567.e11. do 10.1016/j.jac2016.02.029. Epub 2016 Apr 13.
Sor Alvarez J, Manzano A Lopez-Relano J, Cases B, Mas-Fontao A, Canada FJ, Fernandez-Caldas E, Casanovas M, Jenez-Barbero J, Palomares O, Vals-Florez LM, Suba JL. Me allergos coupled to nonoxed mannan from Saccharomyces cerevae effntly target cane dendr cells for novel allergy munotherapy veterary mede. Vet munol munopathol. 2017 Aug;190:65-72. do 10.1016/j.vetm.2017.07.004. Epub 2017 Jul 23.
Nto A, Mazon A, Nto M, anez E, Jang DT, Calaforra S, Alba P, Perez-Frances C, Llusar R, Montoro J, de Mateo A, Alamar R, El-Qutob D, Fernandez J, Moral L, Toral T, Anton M, Andreu C, Ferrer A, Flores , Cerda N, Del Pozo S, Caballero R, Suba JL, Casanovas M. Fst--human phase 2 trl wh me allergos coupled to mannan subcutaneous and sublgual munotherapy. Allergy. 2022 Oct;77(10):3096-3107. do 10.1111/all.15374. Epub 2022 May 27.
Pfaar O, Klek L, Gerth van Wk R. Clally relevant outcome measures for new pharmacotherapy, allergen avoance and munotherapy trls allerg rhoconjunct. Curr Op Allergy Cl munol. 2015 Jun;15(3):197-203. do 10.1097/AC0000000000000164.
Caballero R, Grau A, Javaloyes G, Del Pozo S, Leon MA, Romero M, Casanovas M. Combatn of Allerg Asthma Symptom and Medatn Scores Allergen munotherapy Trls: A Proposal. t Arch Allergy munol. 2021;182(7):571-573. do 10.1159/000513543. Epub 2021 Jan 26. No abstract avaable.
Passalacqua G, Baena-CagnanCE, Bousquet J, Canona GW, Casale TB, Cox L, Durham SR, Larenas-Lnemann D, Ledford D, Pawankar R, Potter P, Rosar N, Wallace D, Lockey RF. Gradg local se effects of sublgual munotherapy for respatory allergy: speakg the same language. J Allergy Cl munol. 2013 Jul;132(1):93-8. do 10.1016/j.jac2013.03.039. Epub 2013 May 15.
Prospective, Randomised, DBPC Clinical Trial to Evaluate the Efficacy and Safety of Polymerized and Mannan Conjugated Allergen Extract of Dermatophagoides for the Treatment of Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05641272Test

المساهمون: Ida Bagus Ramajaya Sutawan, Fellowship Training of Allergy Immunology Division, Department of Child Health Airlangga University, Principal Investigator

المصدر: Gabet S, Rancre F, Just J, de Bl J, LezmG, Amat F, Seta N, Momas Asthma and allerg rh rk depends on house dust me spec E levels PAR bth cohort chdren. World Allergy Organ J. 2019 Oct 4;12(9):100057. do 10.1016/j.waojou.2019.100057. eCollectn 2019 Sep.
Soegrto G, Abdullah MS, DamayantLA, Suseno A, EffendC. The prevalence of allerg deases school chdren of metropolan cy dones shows a sar pattern to that of developed countrs. As Pac Allergy. 2019 Apr 20;9(2):e17. do 10.5415/apallergy.2019.9.e17. eCollectn 2019 Apr.
Calderon MA, Klee-Tebbe J, Lneberg A, De Blay F, Hernandez Fernandez de Rojas D, Vchow JC, Demoly P. House Dust Me Respatory Allergy: An Overvw of Current Therapeut Strategs. J Allergy Cl munol Pract. 2015 Nov-Dec;3(6):843-55. do 10.1016/j.ja.2015.06.019. Epub 2015 Sep 3.
4. Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, et al. Guele on allergen-spec munotherapy E-medted allerg deases. Allergolog. 2015;38(9):431-70.
Q J, Gre K. Complementary and Alternate Treatment for Allerg Condns. Pr Care. 2016 Sep;43(3):519-26. do 10.1016/j.pop.2016.04.012.
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Barlnto W, WulandarD, Chusnah M, Chandra Kusuma HMS, Prawo SR. provement of th17/treg balance and asthma control test score by nella sata supplementatn asthmat chdren: A new approach to managg asthma. Turkh J munol. 2018;6(1):1-7.
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Pfaar O, Demoly P, Gerth van Wk R, BonS, Bousquet J, Canona GW, Durham SR, Jacobsen L, Mallg HJ, Mosges R, Papadopoulos NG, Rak S, Rodruez del R P, Valovta E, Wahn U, Calderon MA; European Academy of Allergy and Clal munology. Recommendatns for the standardatn of clal outcomes used allergen munotherapy trls for allerg rhoconjunct: an EAACPosn Paper. Allergy. 2014 Jul;69(7):854-67. do 10.1111/all.12383. Epub 2014 Apr 25.
Caballero R, Grau A, Javaloyes G, Del Pozo S, Leon MA, Romero M, Casanovas M. Combatn of Allerg Asthma Symptom and Medatn Scores Allergen munotherapy Trls: A Proposal. t Arch Allergy munol. 2021;182(7):571-573. do 10.1159/000513543. Epub 2021 Jan 26. No abstract avaable.
Canona GW, Baena-CagnanCE, Bousquet J, Bousquet PJ, Lockey RF, Mallg HJ, Passalacqua G, Potter P, Valovta E. Recommendatns for standardatn of clal trls wh Allergen Spec munotherapy for respatory allergy. A statement of a World Allergy Organatn (WAO) taskforce. Allergy. 2007 Mar;62(3):317-24. do 10.1111/j.1398-9995.2006.01312.x.
The Efficacy of Nigella Sativa in Children With House Dust Mite-Induced Respiratory Allergy Receiving Immunotherapy

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05450289Test

المؤلفون: BioClever 2005 S.L., NTS hub S.L

المصدر: Beno-Vlalvla C, Sor Suba JL, Palomares O. Novel vacces targetg dendr cells by couplg allergos to mannan. Allergo J t. 2018;27(8):256-262. do 10.1007/s40629-018-0069-8. Epub 2018 May 18.
Svent S, Sor CauquC, Cases B, Manzano A Dz-Rero CM, Reche PA, Lopez-Relano J, Martez-Naves E, Canada FJ, Jenez-Barbero J, Suba J, Casanovas M, Fernandez-Caldas E, Suba JL, Palomares O. Novel vacces targetg dendr cells by couplg allergos to nonoxed mannan enhance allergen uptake and duce functnal regulatory T cells through programmed death land 1. J Allergy Cl munol. 2016 Aug;138(2):558-567.e11. do 10.1016/j.jac2016.02.029. Epub 2016 Apr 13.
Manzano A Javr Canada F, Cases B, Svent S, Sor Palomares O, Fernandez-Caldas E, Casanovas M, Jenez-Barbero J, Suba JL. Structural studs of novel glycoconjugates from polymered allergens (allergos) and mannans as allergy vacces. Glycoconj J. 2016 Feb;33(1):93-101. do 10.1007/s10719-015-9640-4. Epub 2015 Nov 25.
Sor Lopez-Relano J, Vuela M, Tudela J Angela A, Beno-Vlalvla C, Dz-Rero CM, Cases B, Manzano A Fernandez-Caldas E, Casanovas M, Palomares O, Suba JL. Oral myelo cells uptake allergos coupled to mannan drg Th1/Treg responses upon sublgual delery me. Allergy. 2018 Apr;73(4):875-884. do 10.1111/all.13396. Epub 2018 Jan 31.
Sor Alvarez J, Manzano A Lopez-Relano J, Cases B, Mas-Fontao A, Canada FJ, Fernandez-Caldas E, Casanovas M, Jenez-Barbero J, Palomares O, Vals-Florez LM, Suba JL. Me allergos coupled to nonoxed mannan from Saccharomyces cerevae effntly target cane dendr cells for novel allergy munotherapy veterary mede. Vet munol munopathol. 2017 Aug;190:65-72. do 10.1016/j.vetm.2017.07.004. Epub 2017 Jul 23.
Gonzalez JL, Zalve V, Fernandez-Caldas E, Cases B, Suba JL, Casanovas M. A pot study of munotherapy dogs wh atop dermat usg a mannan-Dermatophagoes farae allergo targetg dendr cells. Vet Dermatol. 2018 Oct;29(5):449-e152. do 10.1111/vde.12679.
Prospective, Randomised, DBPC, Double-dummy, Multicenter CT of Efficacy and Safety With IT in Patients With Controlled Mild to Moderate Allergic Asthma and Rhinitis/Rhinoconjunctivitis, Allergic to D. Pteronyssinus and/or D. Farinae.

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05400811Test

المصدر: Efficacy and Safety Assessment of a Subcutaneous Immunotherapy (Beltavac®) With Polymerized Allergenic Extract From House Dust Mites in Patients With Allergic Rhinitis/Rhinoconjuntivitis

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05395689Test

المساهمون: Stefan Zielen, Prof. Dr. med.

المصدر: Parsons JP, Hallstrand TS, Mastronarde JG, Kamsky DA, Rundell KW, Hull JH, Storms WW, Weer JM, Cheek FM, Wson KC, Anderson SD; Ameran Thorac Socty Subcommtee on Exerce-duced Bronchoconstrtn. An offl Ameran Thorac Socty clal practe guele: exerce-duced bronchoconstrtn. Am J Resp Cr Care Med. 2013 May 1;187(9):1016-27. do 10.1164/rccm.201303-0437ST.
Dressler M, Frdrh T, LasowskN, Herrmann E, Zlen S, Schulze J. Predtors and reproducy of exerce-duced bronchoconstrtn cold a. BMC Pulm Med. 2019 May 16;19(1):94. do 10.1186/s12890-019-0845-3.
Dressler M, Salzmann-Manrue E, Zlen S, Schulze J. Exhaled NO as a predtor of exerce-duced asthma cold a. Nr Oxe. 2018 Jun 1;76:45-52. do 10.1016/j.nx.2018.03.004. Epub 2018 Mar 8.
Schulze J, Smh HJ, Fuchs J, Herrmann E, Dressler M, Rose MA, Zlen S. Methachole challenge young chdren as evaluated by spometry and pulse osclometry. Resp Med. 2012 May;106(5):627-34. do 10.1016/j.rmed.2012.01.007. Epub 2012 Feb 10.
Schulze J, Rosewh M, Rmer C, Dressler M, Rose MA, Zlen S. Methachole challenge--comparon of an ATS protocol to a new rap sgle concentratn technue. Resp Med. 2009 Dec;103(12):1898-903. do 10.1016/j.rmed.2009.06.007. Epub 2009 Jul 10.
Schulze J, Rosewh M, Dressler M, Rmer C, Rose MA, Zlen S. Bronchl allergen challenge usg the Meda doseter. t Arch Allergy munol. 2012;157(1):89-97. do 10.1159/000324473. Epub 2011 Sep 7.
Schulze J, Voss S, Zsler U, Rose MA, Zlen S, Schubert R. Away responses and flammatn subjects wh asthma after four days of repeated hh-sgle-dose allergen challenge. Resp Res. 2012 Sep 19;13(1):78. do 10.1186/1465-9921-13-78.
Anderson SD, Charlton B, Weer JM, Nhols S, Spector SL, Pearlman DS; A305 Study Group. Comparon of mannol and methachole to predt exerce-duced bronchoconstrtn and a clal dgnos of asthma. Resp Res. 2009 Jan 23;10(1):4. do 10.1186/1465-9921-10-4.
Drssen JM, van der Palen J, van Aalderen WM, de Jongh FH, Th BJ. spatory aflow latn after exerce challenge cold a asthmat chdren. Resp Med. 2012 Oct;106(10):1362-8. do 10.1016/j.rmed.2012.06.017. Epub 2012 Jul 11.
Zlen S, Lb A, De La Motte S, Wagner F, de Monchy J, Fuhr R, Munzu C, Koehne-Voss S, Rre GJ, Kaer G, Erpenbeck VJ. Omalumab protects agast allergen- duced bronchoconstrtn allerg (munoglobul E-medted) asthma. t Arch Allergy munol. 2013;160(1):102-10. do 10.1159/000339243. Epub 2012 Aug 28.
Rosewh M, Zsler UM, KheT, Voss S, Ekmer O, Schulze J, Herrmann E, Ducker RP, Schubert R, Zlen S. Away flammatn chdren and adolescents wh bronchl oblerans. Cytoke. 2015 May;73(1):156-62. do 10.1016/j.cyto.2014.10.026. Epub 2015 Mar 6.
Jerk SP, Mhel F, Donath H, Herrmann E, Schubert R, Rosewh M, Zlen S. Calprotect as a New Sense Marker of Neutroph flammatn Patnts wh Bronchl Oblerans. Medtors flamm. 2020 May 1;2020:4641585. do 10.1155/2020/4641585. eCollectn 2020.
Fussbroh D, Kohnle C, Schwenger T, Drssler C, Ducker RP, Ekmer O, Gottwald G, Jerk SP, Zlen S, Kreyenberg H, Beermann C, ChcchettAG, Schubert R. A combatn of LCPUFAs regulates the expressn of mNA-146a-5p a mure asthma model and human alveolar cells. Prostaglands Other L Medt. 2020 Apr;147:106378. do 10.1016/j.prostaglands.2019.106378. Epub 2019 Nov 4.
Tan Z, Randall G, Fan J, CamorettMercado B, Brockman-Schneer R, Pan L, Solway J, Gern JE, Lemanske RF, Nolae D, Ober C. Allele-spec targetg of mroRNAs to HLA-G and rk of asthma. Am J Hum Genet. 2007 Oct;81(4):829-34. do 10.1086/521200. Epub 2007 Aug 20. Erratum : Am J Hum Genet. 2008 Jan;82(1):251.
Zhang YY, Zhong M, Zhang MY, Lv K. [Expressn and clal snance of m-155 perheral blood CD4(+);T cells of patnts wh allerg asthma]. XBao Yu Fen ZMn YXue Za Zh 2012 May;28(5):540-3. Chese.
Lu TX, Munz A, Rothenberg ME. MroRNA-21 up-regulated allerg away flammatn and regulates -12p35 expressn. J munol. 2009 Apr 15;182(8):4994-5002. do 10.4049/jmunol.0803560.
Mattes J, Collon A, Plank M, Phps S, Foster PS. Antagonm of mroRNA-126 suppresses the effector functn of TH2 cells and the development of allerg aways dease. Proc Natl Acad ScU S A. 2009 Nov 3;106(44):18704-9. do 10.1073/pnas.0905063106. Epub 2009 Oct 20.
Wlms AE, Larner-Svensson H, Perry MM, Campbell GA, Herrk SE, Adcock , Erjefalt JS, Chung KF, Ldsay MA. MroRNA expressn profg md asthmat human aways and effect of cortostero therapy. PLoS One. 2009 Jun 12;4(6):e5889. do 10.1371/journal.pone.0005889.
Polepahad S, Knht JM, NaghavAO, Oplt T, Crehton CJ, Shaw C, Benham AL, K J, Soam B, Harr RA, Coarfa C, Zarf A, Mosavljev A, Batts LM, Kheradmand F, Gunaratne PH, Corry DB. Proflammatory role for let-7 mroRNAS experental asthma. J Bl Chem. 2010 Sep 24;285(39):30139-49. do 10.1074/jbc.M110.145698. Epub 2010 Jul 14.
Cha Y, Tanabe M, Goto K, SakaH, Mawa M. Down-regulatn of m-133a contrutes to up-regulatn of Rhoa bronchl smooth muscle cells. Am J Resp Cr Care Med. 2009 Oct 15;180(8):713-9. do 10.1164/rccm.200903-0325OC. Epub 2009 Jul 30.
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GarbackN, DValent E, Huynh-Thu VA, Geurts P, rthum A, Crahay C, Arnould T, Deroanne C, Ptte J, Cataldo D, Cole A. MroRNAs profg mure models of acute and chron asthma: a relatnsh wh mRNAs targets. PLoS One. 2011 Jan 28;6(1):e16509. do 10.1371/journal.pone.0016509.
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Omran A, Elam D, Y F. MroRNAs: new shts to chron chdhood deases. Bmed Res t. 2013;2013:291826. do 10.1155/2013/291826. Epub 2013 Jun 27.
Epigenetic Regulation of Excercise Induced Asthma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05174689Test

المؤلفون: Hannover Medical School

المساهمون: Prof. Dr. Jens Hohlfeld, Prof. Dr. Jens M Hohlfeld

المصدر: Werfel T, Allam JP, Bdermann T, Eyerh K, Gles S, Guttman-Yassky E, Hoetzenecker W, Knol E, Son HU, Wollenberg A, Bber T, Lauener R, Schm-Grendelmer P, Tral-Hoffmann C, Akd CA. Cellular and molecular munolog mechanms patnts wh atop dermat. J Allergy Cl munol. 2016 Aug;138(2):336-49. do 10.1016/j.jac2016.06.010.
Werfel T, Heratadeh A, Nbuhr M, Kapp A, Roesner LM, Karch A, Erpenbeck VJ, Losche C, Jung T, Krug N, Badorrek P, Hohlfeld JM. Exacerbatn of atop dermat on grass pollen exposure an envonmental challenge chamber. J Allergy Cl munol. 2015 Jul;136(1):96-103.e9. do 10.1016/j.jac2015.04.015. Epub 2015 Jun 1.
Sager N, Feldmann A, Schlg G, Kresch P, Neumann C. House dust me-spec T cells the sk of subjects wh atop dermat: frequency and lymphoke profe the allergen patch test. J Allergy Cl munol. 1992 Apr;89(4):801-10. do 10.1016/0091-6749(92)90434-4.
Chamber Exposure With House Dust Mite (HDM) or Allergen-free Air in Atopic Drmatitis Patients With HDM Sensitization to Investigate the Role of Aeroallergen Exposure on Skin Responses and T Cell Immunology

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05019209Test

المؤلفون: Pfizer

المصدر: The Incidence of Venous Thromboembolism in Atopic Dermatitis: A Matched Cohort Analysis in UK Primary Care

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04969653Test

المؤلفون: BioClever 2005 S.L., NTS hub S.L

المصدر: Suba J, Fel A, Suba JL, Uhl J, Fernandez-Caldas E. Cluster munotherapy wh a glutaraldehyde-modd mture of grasses results an provement spec nasal provocatn tests less than 2.5 months of treatment. Cl Exp Allergy. 2008 Jun;38(6):987-94. do 10.1111/j.1365-2222.2008.02995.x. Epub 2008 Apr 25.
Klek L, Uhl J, Mosges R, Rett K, Pfaar O. A hh polymered grass pollen extract effacus and safe a randomed double-bld, placebo-controlled study usg a novel up-dosg cluster-protocol. Allergy. 2014 Dec;69(12):1629-38. do 10.1111/all.12513. Epub 2014 Oct 6.
Guzman-Fulgenc M, Caballero R, Lara B, Mena M, Tejera M, Sastre A, Suba JL, Fernandez-Caldas E, Casanovas M. Safety of munotherapy wh glutaraldehyde modd allergen extracts chdren and adults. Allergol munopathol (Madr). 2017 Mar-Apr;45(2):198-207. do 10.1016/j.aller.2016.08.008. Epub 2016 Dec 7.
Prospective, Randomized, Placebo-controlled, Multi-center Trial Comparing the Efficacy and Safety of Subcutaneous Immunotherapy With a Mixture of Grasses and Mites at Adequate Doses Versus Monotherapy, for the Treatment of Allergy

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04874714Test

المؤلفون: Bencard Allergie GmbH

المصدر: Bergmann, KC., Raab, J., Krause, L. et al. Long-term benefits of targeted micronutrition with the holoBLG lozenge in house dust mite allergic patients. Allergo J Int (2022). https://doi.org/10.1007/s40629-021-00197-zTest
Evaluation of the Long-term Effect of a 3-month Supplementation With Holo-BLG (Food for Special Medical Purposes) in People With Allergic Rhinoconjunctivitis Caused by House Dust Mites During Inhalation Exposure to Mite Allergen in an Exposure Chamber.

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04872868Test

المصدر: Effects of Tregalizumab on Allergen-induced Airway Responses and Airway Inflammation in Asthmatic Patients

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04673591Test