دورية أكاديمية
Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors
| العنوان: | Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors |
|---|---|
| المؤلفون: | Kouvaras E., Christoni Z., Siasios I., Malizos K., Koukoulis G.K., Ioannou M. |
| المصدر: | Biotechnic and Histochemistry ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059520952&doi=10.1080%2f10520295.2018.1556806&partnerID=40&md5=1b2f11b6eff26ef4a3def4fa016b7aceTest |
| سنة النشر: | 2019 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | HIF1A protein, human, hypoxia inducible factor 1alpha, vasculotropin A, adult, aged, bone tumor, chondroma, chondrosarcoma, female, gene expression regulation, genetics, immunohistochemistry, male, metabolism, middle aged, neovascularization (pathology), physiology, very elderly, 80 and over, Bone Neoplasms, Neoplastic, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Neovascularization, Pathologic, Vascular Endothelial Growth Factor A, Taylor and Francis Ltd |
| الوصف: | Neoangiogenesis has been demonstrated in chondrosarcoma. Anti-angiogenic therapies are being tested in clinical trials for chondrosarcomas. Studies of the underlying mechanisms have been performed almost exclusively in cell lines. We immunostained 20 samples of chondrosarcoma and 20 samples of enchondromas with antibodies against hypoxia-inducible factor 1-alpha (HIF-1-alpha) and vascular endothelial growth factor (VEGF). The immunohistochemical staining of HIF-1-alpha and VEGF were highly correlated. Enchondromas were HIF-1-alpha and VEGF negative, whereas all chondrosarcoma exhibited HIF-1-alpha and VEGF immunostaining. HIF-1-alpha/VEGF double positive cases were almost exclusively chondrosarcomas with a high tumor grade. We suggest that HIF-1-alpha is a marker of malignancy in chondrosarcomas that correlates with tumor neo-angiogenesis. Our findings also suggest that a HIF-1-alpha/VEGF angiogenic pathway may exist in chondrosarcoma in vivo as in other malignant tumors. The inclusion of novel inhibitors to HIF-1-alpha and other factors may optimize anti-angiogenic interventions in chondrosarcoma. © 2018, © 2018 The Biological Stain Commission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 10520295 |
| العلاقة: | http://hdl.handle.net/11615/75446Test |
| DOI: | 10.1080/10520295.2018.1556806 |
| الإتاحة: | https://doi.org/10.1080/10520295.2018.1556806Test http://hdl.handle.net/11615/75446Test |
| رقم الانضمام: | edsbas.8EE09A98 |
| قاعدة البيانات: | BASE |
| تدمد: | 10520295 |
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| DOI: | 10.1080/10520295.2018.1556806 |