دورية أكاديمية
Microstructural and in vitro characterization of SiO2-Na 2O-CaO-MgO glass-ceramic bioactive scaffolds for bone substitutes
| العنوان: | Microstructural and in vitro characterization of SiO2-Na 2O-CaO-MgO glass-ceramic bioactive scaffolds for bone substitutes |
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| المؤلفون: | Vitale Brovarone C., Verne' E., Bosetti M., Appendino P., Cannas M. |
| المساهمون: | Vitale Brovarone, C., Verne', E., Bosetti, M., Appendino, P., Cannas, M. |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2005 |
| المجموعة: | PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino) |
| مصطلحات موضوعية: | Body Fluid, Bone Substitute, Cell Proliferation, Cell Survival, Cells, Cultured, Ceramic, Compressive Strength, Gla, Human, Materials Testing, Molecular Conformation, Osseointegration, Osteoblast, Porosity, Starch, Surface Properties |
| الوصف: | In the present research work, the preparation and characterization of bioactive glass-ceramic scaffolds for bone substitutes are described. The scaffolds were prepared by starch consolidation of bioactive glass powders belonging to the SiO2-Na2O-CaO-MgO system using three different organic starches (corn, potatoes and rice) as reported in a previous screening process [1]. The scaffolds, characterized by scanning electron microscopy, showed a porous structure with highly interconnected pores. The pores sizes assessed by mercury intrusion porosimetry put in evidence the presence of pores of 50-100 μm. The structure of the scaffolds was investigated by X-ray diffraction and revealed the glass-ceramic nature of the obtained material. The mechanical properties of the scaffolds were evaluated by means of compressive tests on cubic samples and the obtained results demonstrated their good mechanical strength. The in vitro bioactivity of the scaffolds was tested by soaking them in a simulated body fluid (SBF) and by subsequently characterizing the soaked surfaces by SEM, EDS and X-ray diffraction. Good in vitro bioactivity was found for the starting glass and for the obtained scaffolds. Moreover, the scaffold bioresorption, tested by measuring the samples weight loss in SBF at different periods of time, showed a partial resorption of the scaffolds. Cell culture testing of the three different scaffolds indicated no differences in cell number and in alkaline phosphatase activity; the morphology of the osteoblasts showed good spreading, comparable to bulk material which was used as the control. © 2005 Springer Science + Business Media, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000231941200004; volume:16; issue:10; firstpage:909; lastpage:917; numberofpages:9; journal:JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE; http://hdl.handle.net/11583/2897254Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-25144493247 |
| DOI: | 10.1007/s10856-005-4425-0 |
| الإتاحة: | https://doi.org/10.1007/s10856-005-4425-0Test http://hdl.handle.net/11583/2897254Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.2EBAB7D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10856-005-4425-0 |
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