دورية أكاديمية
Prognostic Value of Lactate Dehydrogenase in Patients with Melanoma Treated with Pembrolizumab
| العنوان: | Prognostic Value of Lactate Dehydrogenase in Patients with Melanoma Treated with Pembrolizumab |
|---|---|
| المؤلفون: | Popović, Aleksandar, Petković, Ivan, Dimitrijevic, Aleksandra, Jović, Andrija |
| المصدر: | Acta Dermatovenerologica Croatica ; ISSN 1330-027X (Print) ; ISSN 1847-6538 (Online) ; Volume 31 ; Issue 2 |
| بيانات النشر: | Acta Dermatovenerologica Croatica |
| سنة النشر: | 2023 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | melanoma, pembrolizumab, lactate dehydrogenase |
| الوصف: | Introduction: Elevated LDH levels have been extensively reported as a biomarker of poorer outcome in patients with melanoma during the chemotherapeutic era. The role of LDH level as a prognostic factor for treatment outcomes in patients with metastatic melanoma treated with immunooncological therapy has also been reported but requires further analysis. Objectives: In this study, we aimed to evaluate the prognostic value of lactate dehydrogenase (LDH) among patients with metastatic and unresectable melanoma treated with pembrolizumab in terms of pro- gression-free survival (PFS). Methods: The study included 59 patients with unresectable and met- astatic melanoma treated with pembrolizumab. A comparison was performed between patients with normal and elevated levels of LDH in terms of PFS, with subgroup analysis. Results: There was a significant reduction in PFS among patients with elevated levels of LDH compared with patients with normal levels of LDH (NR vs. 5 months; P=0.02). Patients with elevated LDH levels were older (P=0.01), with liver metastasis (P=0.004), and with less frequent CNS deposits (P=0.028). Conclusion: Although novel agents improved outcomes in patients with melanoma, high levels of LDH persist as an independent prog- nostic biomarker of poor prognosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hrcak.srce.hr/311639Test |
| الإتاحة: | https://hrcak.srce.hr/311639Test https://hrcak.srce.hr/file/449998Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DE977168 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |