دورية أكاديمية
Macrophage subsets in obesity, aligning the liver and adipose tissue
| العنوان: | Macrophage subsets in obesity, aligning the liver and adipose tissue |
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| المؤلفون: | Remmerie, Anneleen, Martens, Liesbet, Scott, Charlotte |
| المصدر: | FRONTIERS IN ENDOCRINOLOGY ; ISSN: 1664-2392 |
| سنة النشر: | 2020 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, Medicine and Health Sciences, NONALCOHOLIC STEATOHEPATITIS, LOCAL PROLIFERATION, HEPATIC RECRUITMENT, ADIPOCYTE DEATH, SPI-C, CELLS, INFLAMMATION, DEPLETION, NICHE, POLARIZATION, macrophages, adipose tissue, non-alcoholic fatty liver disease (NAFLD), single-cell, heterogeneity, liver, NASH (non-alcoholic steatohepatitis) |
| الوصف: | The increasing prevalence of obesity is accompanied by a rising incidence in metabolic syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages are hypothesized to play central roles in these diseases, through their role as inflammatory mediators and as such are thought to be potential targets for future therapies. Recently, single cell technologies have revealed significant heterogeneity within the macrophage pool in both liver and adipose tissue in obesity. Thus current efforts are focused on dissecting this heterogeneity and understanding the distinct functions of the individual subsets. In this review, we discuss the current knowledge regarding macrophage heterogeneity, ontogeny and functions in the context of obese adipose tissue and fatty liver disease and attempt to align the distinct populations described to date. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/plain |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8672783Test; http://hdl.handle.net/1854/LU-8672783Test; http://dx.doi.org/10.3389/fendo.2020.00259Test; https://biblio.ugent.be/publication/8672783/file/8672784Test |
| DOI: | 10.3389/fendo.2020.00259 |
| الإتاحة: | https://doi.org/10.3389/fendo.2020.00259Test https://biblio.ugent.be/publication/8672783Test http://hdl.handle.net/1854/LU-8672783Test https://biblio.ugent.be/publication/8672783/file/8672784Test |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F96624F6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2020.00259 |
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