Extracellular volume fraction measurements derived from the longitudinal relaxation of blood-based synthetic hematocrit may lead to clinical errors in 3 T cardiovascular magnetic resonance
التفاصيل البيبلوغرافية
العنوان:
Extracellular volume fraction measurements derived from the longitudinal relaxation of blood-based synthetic hematocrit may lead to clinical errors in 3 T cardiovascular magnetic resonance
Abstract Background The extracellular volume (ECV), derived from cardiovascular magnetic resonance (CMR) T1 mapping, is a biomarker of the extracellular space in the myocardium. The hematocrit (HCT), measured from venipuncture, is required for ECV measurement. We test the clinic values of synthetic ECV, which is derived from the longitudinal relaxation of blood–based (T1blood) synthetic hematocrit in 3 T CMR. Methods A total of 226 subjects with CMR T1 mapping and HCT measurement taken on the same day as the CMR were retrospectively enrolled and randomly split into derivation (n = 121) and validation (n = 105) groups, comprising healthy subjects (n = 45), type 2 diabetes mellitus (T2DM) patients (n = 60), hypertrophic cardiomyopathy (HCM) patients (n = 93), and 28 other patients. Correlation of T1blood with the measured HCT (HCTm) was established in the derivation group and used in both the derivation and the validation groups. The relationships between the ECV values derived from both the synthetic HCT (HCTsyn) and HCTm were explored. In addition, the differences in the ECV values among the HC, T2DMs, and HCMs were compared. Results Regression between the HCTm and 1/T1blood was linear (R2 = 0.19, p
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