المؤلفون: Jun Liang (251318), Jason R. Zbieg (1892965), Robert A. Blake (8974823), Jae H. Chang (1429789), Stephen Daly (2430460), Antonio G. DiPasquale (1274730), Lori S. Friedman (166879), Thomas Gelzleichter (11113391), Matthew Gill (589302), Jennifer M. Giltnane (11113394), Simon Goodacre (1577413), Jane Guan (166826), Steven J. Hartman (10157036), Ellen Rei Ingalla (8908757), Lorn Kategaya (11113397), James R. Kiefer (1443889), Tracy Kleinheinz (1845637), Sharada S. Labadie (1833826), Tommy Lai (2572615), Jun Li (6494), Jiangpeng Liao (1947631), Zhiguo Liu (594653), Vidhi Mody (8908760), Neville McLean (2128303), Ciara Metcalfe (8908763), Michelle A. Nannini (11113400), Jason Oeh (1845505), Martin G. O’Rourke (11113403), Daniel F. Ortwine (1600621), Yingqing Ran (2100610), Nicholas C. Ray (3064926), Fabien Roussel (3030714), Amy Sambrone (1551289), Deepak Sampath (640340), Leah K. Schutt (11113406), Maia Vinogradova (8908772), John Wai (1503217), Tao Wang (12008), Ingrid E. Wertz (11113409), Jonathan R. White (11113412), Siew Kuen Yeap (1346391), Amy Young (251900), Birong Zhang (1947472), Xiaoping Zheng (566379), Wei Zhou (24328), Yu Zhong (291917), Xiaojing Wang (147040)

مصطلحات موضوعية: Cell Biology, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Exceptional Preclinical Profile, dose, Bioavailable, human, candidate, combination, liability, Phase, Orally, antagonist, Breast Cancer Breast cancer, wild-type ER α tumor model, GDC -9545, estrogen receptor degrader, antiproliferation, SERD, interaction, Estrogen Receptor Antagonist, giredestrant, Fine-tuning, PDX

العلاقة: https://figshare.com/articles/journal_contribution/GDC-9545_Giredestrant_A_Potent_and_Orally_Bioavailable_Selective_Estrogen_Receptor_Antagonist_and_Degrader_with_an_Exceptional_Preclinical_Profile_for_ER_Breast_Cancer/14959973Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00847.s001Test

المؤلفون: Chin Wong, Thomas Gelzleichter, Junichiro Sonoda, Amos Baruch, Linda Morrow, Suresh Dheerendra, Leslie W. Chinn, Richard Boismenu, Eric Wakshull, Maria E. Wilson, Puneet S. Arora, Shan Chen, Anjali Vaze, Johnny Gutierrez, Nicholas Lewin-Koh

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Male, 0301 basic medicine, obesity, Medical Sciences, FGF21, Adipose tissue, Mice, 0302 clinical medicine, Weight loss, Homeostasis, Medicine, Multidisciplinary, biology, Middle Aged, Biological Sciences, Adipose Tissue, Female, Adiponectin, Antibody, medicine.symptom, FGF21 receptor activation, Adult, Agonist, medicine.medical_specialty, Adolescent, medicine.drug_class, 030209 endocrinology & metabolism, Antibodies, Food Preferences, Young Adult, 03 medical and health sciences, Internal medicine, Weight Loss, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 1, Aged, business.industry, Fibroblast growth factor receptor 1, Body Weight, medicine.disease, Obesity, Fibroblast Growth Factors, stomatognathic diseases, Macaca fascicularis, 030104 developmental biology, Endocrinology, biology.protein, food preference, business, metabolism, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1e6fc5999a3fd66bc3ad16e368b18Test
https://doi.org/10.1073/pnas.2012073117Test

المؤلفون: Sharmila Rajan, Thomas Gelzleichter, Amos Baruch, Junichiro Sonoda, C. Andrew Boswell, Dale Stevens, Eric Stefanich, Danielle Mandikian, Kyra J. Cowan

المصدر: mAbs. 9:1379-1388

مصطلحات موضوعية: Male, 0301 basic medicine, Receptor complex, FGF21, medicine.drug_class, Receptor expression, Immunology, Drug Evaluation, Preclinical, Adipose tissue, CHO Cells, Pharmacology, Biology, Diet, High-Fat, Monoclonal antibody, 03 medical and health sciences, Cricetulus, Report, Cricetinae, medicine, Animals, Immunology and Allergy, Tissue Distribution, Obesity, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Adiponectin, Fibroblast growth factor receptor 1, Antibodies, Monoclonal, Fibroblast Growth Factors, Mice, Inbred C57BL, Macaca fascicularis, 030104 developmental biology, Adipose Tissue, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe09bafc48ef65e54437fd42a8236afTest
https://doi.org/10.1080/19420862.2017.1373923Test

المؤلفون: Diana Ronai Dunshee, Jose Zavala-Solorio, Hok Seon Kim, Sharmila Rajan, Yongmei Chen, James A. Ernst, Elizabeth Luis, Ai-Luen Wu, Robert Soriano, Ganesh Kolumam, Amos Baruch, Mark Z. Chen, Raymond K. Tong, Shelby K. Wyatt, Richard A.D. Carano, Christoph Spiess, Owen P. McGuinness, Jean-Michel Vernes, Andrew S. Peterson, Søren Warming, Keith R. Anderson, Xin Y. Rairdan, Junichiro Sonoda, Matthew J. Brauer, Scott Stawicki, Benjamin Haley, Laetitia Comps-Agrar, Jed Ross, Y. Gloria Meng, Johnny Gutierrez, James Ziai, Thomas Gelzleichter, Travis W. Bainbridge, Nicholas Lewin-Koh, Yan Wu, Nicholas van Bruggen, Vineela D. Gandham, Lance Kates, Yingnan Zhang, Dale Stevens

المصدر: EBioMedicine, Vol 2, Iss 7, Pp 730-743 (2015)
EBioMedicine

مصطلحات موضوعية: Male, FGF21, medicine.medical_treatment, Bispecific antibody, Adipose tissue, Mice, Obese, lcsh:Medicine, White adipose tissue, Brown adipose tissue, FGF19, Therapeutic antibody, Adipose Tissue, Brown, Antibodies, Bispecific, Insulin, Mice, Inbred BALB C, lcsh:R5-920, NASH, Thermogenesis, Type 2 diabetes, General Medicine, medicine.anatomical_structure, Original Article, Adipose tissue browning, Adiponectin, lcsh:Medicine (General), Protein Binding, medicine.medical_specialty, UCP1, Humanized antibody, Biology, General Biochemistry, Genetics and Molecular Biology, Cell Line, Insulin resistance, Internal medicine, Weight Loss, medicine, Animals, Humans, betaKlotho, Receptor, Fibroblast Growth Factor, Type 1, Obesity, Klotho Proteins, Fibroblast growth factor receptor 1, lcsh:R, Membrane Proteins, Hepatosteatosis, medicine.disease, Fibroblast Growth Factors, Mice, Inbred C57BL, Macaca fascicularis, Endocrinology, HEK293 Cells, FGFR1, Energy Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292cc2ae94284197f1952ee9ad725380Test
http://www.sciencedirect.com/science/article/pii/S235239641530030XTest

المؤلفون: Suhasini Iyer, Sherry Yeh, Kathy Howell, Mercedesz Balazs, Laura DeForge, Jeffrey Thompson, Allen J. Ebens, Zhonghua Lin, Christine Ambrose, Maya Leabman, Germaine Fuh, Shiming Ye, Wyne P. Lee, Qinglin Ou, Thomas Gelzleichter, Chingwei V. Lee, Wei Yu Lin, Dimitry M. Danilenko, Melissa A. Starovasnik, Joseph Beyer, Qian Gong, Dhaya Seshasayee, Flavius Martin, Jean Shu, Eric Suto

المصدر: Blood. 110:3959-3967

مصطلحات موضوعية: Cell Survival, medicine.drug_class, medicine.medical_treatment, Plasma Cells, Immunology, Bone Marrow Cells, Monoclonal antibody, Biochemistry, Lymphocyte Depletion, Mice, Species Specificity, Antigen, Neoplasms, B-Cell Activating Factor, Animals, Medicine, B-cell activating factor, B cell, CD20, Mice, Inbred BALB C, biology, business.industry, Antibodies, Monoclonal, Cell Biology, Hematology, Immunotherapy, Blockade, Macaca fascicularis, medicine.anatomical_structure, Immune System Diseases, biology.protein, Antibody, business, B-Cell Activation Factor Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d141204a369c61e0bbe2e44212d6aTest
https://doi.org/10.1182/blood-2007-04-088088Test

المؤلفون: Wyne P. Lee, Dong Xie, Ezogelin Oflazoglu, Sean K. Kelley, Iqbal S. Grewal, Ferhan Qureshi, Walter C. Darbonne, Thomas Gelzleichter, Kim Kissler

المصدر: British Journal of Pharmacology. 148:1116-1123

مصطلحات موضوعية: Pharmacology, biology, business.industry, Preclinical pharmacokinetics, Pharmacodynamics, Preclinical pharmacology, biology.protein, Medicine, Anti cd40, Antibody, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fdd300528a6ed40f282d1931d356f1ddTest
https://doi.org/10.1038/sj.bjp.0706828Test

المؤلفون: Wesley Chang, Kathy Howell, Susan Sa, Ben Wu, Flavius Martin, Yulia Vugmeyster, Anahid Storn, Thomas Gelzleichter, Dimitry M. Danilenko, An Song, Jeffrey Thompson, Iqbal S. Grewal, Barbara Ehrenfels, Song Ren, Ellen Gilkerson, Tenea Nelson, Dhaya Seshasayee

المصدر: The American Journal of Pathology. 168:476-489

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Cell Survival, Lymphoid Tissue, Recombinant Fusion Proteins, Biology, Follicular cell, Receptors, Tumor Necrosis Factor, Pathology and Forensic Medicine, Blood cell, B-Cell Activating Factor, medicine, Animals, Humans, BAFF receptor, B-cell activating factor, Receptor, Cell Proliferation, B-Lymphocytes, Tumor Necrosis Factor-alpha, Membrane Proteins, Flow Cytometry, Marginal zone, Molecular biology, Immunoglobulin Fc Fragments, Original Research Paper, Macaca fascicularis, Lymphatic system, medicine.anatomical_structure, Immunoglobulin G, Female, Tumor necrosis factor alpha, B-Cell Activation Factor Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0e9c1218e893ff0523292eb6075db8Test
https://doi.org/10.2353/ajpath.2006.050600Test

المؤلفون: Ihsan Nijem, Ellen Filvaroff, Jing Peng, Christophe Severin, Judy Young, Mally Romero, Youjun Chen, Surinder Kaur, Elaine Mai, Zhong Zheng, Mark Merchant, William Mallet, Thomas Gelzleichter

المصدر: Molecular cancer therapeutics. 13(2)

مصطلحات موضوعية: Cancer Research, medicine.drug_class, Mice, Nude, Mice, Transgenic, Mice, SCID, Pharmacology, Monoclonal antibody, Immunofluorescence, Flow cytometry, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Immunoassay, Mice, Inbred C3H, biology, medicine.diagnostic_test, Dose-Response Relationship, Drug, Hepatocyte Growth Factor, Antibodies, Monoclonal, Proto-Oncogene Proteins c-met, Flow Cytometry, Xenograft Model Antitumor Assays, In vitro, Endocytosis, Macaca fascicularis, Oncology, Onartuzumab, Microscopy, Fluorescence, Monoclonal, biology.protein, Hepatocyte growth factor, RNA Interference, Antibody, Biomarkers, medicine.drug, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b103514e47d95e5f7065f05fe15b26eaTest
https://pubmed.ncbi.nlm.nih.gov/24258345Test

المؤلفون: Sean K, Kelley, Thomas, Gelzleichter, Dong, Xie, Wyne P, Lee, Walter C, Darbonne, Ferhan, Qureshi, Kim, Kissler, Ezogelin, Oflazoglu, Iqbal S, Grewal

المصدر: British journal of pharmacology. 148(8)

مصطلحات موضوعية: Male, Macaca fascicularis, Mice, Species Specificity, Papers, otorhinolaryngologic diseases, Animals, Antibodies, Monoclonal, Enzyme-Linked Immunosorbent Assay, sense organs, Mice, SCID, CD40 Antigens, Flow Cytometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::37d0f3daf2f60e1632a9ff1fc6edb7a7Test
https://pubmed.ncbi.nlm.nih.gov/16847437Test

المؤلفون: Clarissa David, Anahid Storn, Eric Stefanich, Kathleen Howell, Khanh Pham, Olivia Hwang, Marna Williams, Quyen Nguyen, Jeffery Lutman, Dimitry M. Danilenko, Franklin Fuh, Hong Wang, Sharon O'Byrne, Thomas Gelzleichter, Karen Berry, Shweta Gadkari, Chikara Takahashi

المصدر: Gastroenterology. 134:A-99

مصطلحات موضوعية: Hepatology, biology, business.industry, Immunology, Gastroenterology, biology.protein, Medicine, Antibody, business, Anti-Beta7, Homing (hematopoietic)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::30cda213ab606f5ba38583eb33e20195Test
https://doi.org/10.1016/s0016-5085Test(08)60465-5