التفاصيل البيبلوغرافية
| العنوان: |
Transitional Dynamics of Sarcopenia and Associations of Nutritional Indices with State Transitions in Chinese aged ≥ 50. |
| المؤلفون: |
Li, Y., Xiang, Q., Dong, B., Liang, R., Song, Q., Deng, L., Ge, Ning, Yue, Jirong |
| المصدر: |
Journal of Nutrition, Health & Aging; Sep2023, Vol. 27 Issue 9, p741-751, 11p |
| مصطلحات موضوعية: |
DISEASE progression, NUTRITIONAL assessment, SKINFOLD thickness, SARCOPENIA, RISK assessment, SERUM albumin, VITAMIN D, INDEPENDENT living, DESCRIPTIVE statistics, RESEARCH funding, BODY movement, MUSCLE strength, BODY mass index, LONGITUDINAL method, ARM circumference, NUTRITIONAL status, MIDDLE age |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Objectives: Sarcopenia's temporal profile can be regarded as a dynamic process with distinct states, in which malnutrition plays an important role. This study aimed to address two research gaps: sarcopenia's transitional dynamics and associations of nutritional indices with state transitions in community-dwelling Chinese adults aged 50 and older. Design: A prospective population-based cohort study. Setting: Community-based setting in western China. Participants: The analytic sample included data from 1910 participants aged ≥ 50 in the West China Health and Aging Trend study between 2018–2022. Measurements: We defined three states: the initial normal state (normal muscle strength, physical performance and muscle mass), the worst sarcopenia state (low muscle mass plus low muscle strength and/or low physical performance) and the intermediate subclinical state (the other scenarios). The relevant measurement methods and cut-off points were based on the 2019 AWGS consensus. Using a continuous-time multistate Markov model, we calculated probabilities of transitions between different states over 1, 2 and 4 years; we also examined associations between nutritional indices and transitions, including body mass index (BMI), calf circumference (CC), mid-arm circumference (MAC), triceps skinfold thickness (TST), albumin (ALB), geriatric nutrition risk index (GNRI), vitamin D (VitD) and prealbumin (PA). Results: For individuals in the normal state, their probabilities of remaining stable versus progressing to a subclinical state were 53.4% versus 42.1% at 2 years, and 40.6% versus 49.0% at 4 years. In the subclinical population, their 2- and 4-year chances were 60.2% and 51.2% for maintaining this state, 11.8% and 16.2% for developing sarcopenia, 28.0% and 32.6% for reverting to normal. For sarcopenic individuals, the likelihood of staying stable versus retrogressing to the subclinical state were 67.0% versus 26.3% at 2 years, and 48.3% versus 36.3% at 4 years. Increased BMI, CC, MAC, TST, ALB, GNRI and PA correlated with reversion from the subclinical state, among which increased TST, ALB and PA were also paralleled with reversion from sarcopenia, while decreased BMI, CC, MAC, TST and GNRI were associated with progression to sarcopenia. VitD was not significantly associated with any transitions. Conclusion: This study reveals how sarcopenia changes over time in a Chinese population. It also highlights the usefulness of simple and cost-effective nutritional status indices for indicating state transitions, which can help identify individuals at risk of sarcopenia and guide targeted interventions within the optimal time window. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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