The CD36-PPARγ Pathway in Metabolic Disorders
| العنوان: | The CD36-PPARγ Pathway in Metabolic Disorders |
|---|---|
| المؤلفون: | Maximilien Laviolette, André J. Tremblay, Michèle Brochu, Amélie Rodrigue-Way, Véronique Caron, Baly Sow, Loïze Maréchal |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 5, p 1529 (2018) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | CD36 Antigens, 0301 basic medicine, Peroxisome proliferator-activated receptor, Review, Pharmacology, scavenger receptor, hexarelin, lcsh:Chemistry, 0302 clinical medicine, insulin resistance, Drug Discovery, PPAR nuclear receptors, energy metabolism, Receptor, lcsh:QH301-705.5, fatty acid oxidation, Spectroscopy, chemistry.chemical_classification, Fatty Acids, General Medicine, 3. Good health, Computer Science Applications, lipids (amino acids, peptides, and proteins), Signal transduction, Oligopeptides, Signal Transduction, 030209 endocrinology & metabolism, Catalysis, Inorganic Chemistry, PGC-1, 03 medical and health sciences, Insulin resistance, Metabolic Diseases, Coactivator, medicine, Animals, Humans, GHRP, Physical and Theoretical Chemistry, Scavenger receptor, Molecular Biology, Organic Chemistry, medicine.disease, PPAR gamma, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Nuclear receptor, chemistry, Mitochondrial biogenesis, atherosclerosis |
| الوصف: | Uncovering the biological role of nuclear receptor peroxisome proliferator-activated receptors (PPARs) has greatly advanced our knowledge of the transcriptional control of glucose and energy metabolism. As such, pharmacological activation of PPARγ has emerged as an efficient approach for treating metabolic disorders with the current use of thiazolidinediones to improve insulin resistance in diabetic patients. The recent identification of growth hormone releasing peptides (GHRP) as potent inducers of PPARγ through activation of the scavenger receptor CD36 has defined a novel alternative to regulate essential aspects of lipid and energy metabolism. Recent advances on the emerging role of CD36 and GHRP hexarelin in regulating PPARγ downstream actions with benefits on atherosclerosis, hepatic cholesterol biosynthesis and fat mitochondrial biogenesis are summarized here. The response of PPARγ coactivator PGC-1 is also discussed in these effects. The identification of the GHRP-CD36-PPARγ pathway in controlling various tissue metabolic functions provides an interesting option for metabolic disorders. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af4b214143fe2705fbb1e55b81dfd3eTest https://doi.org/10.3390/ijms19051529Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8af4b214143fe2705fbb1e55b81dfd3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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