Genomic predictors of interindividual differences in response to DNA damaging agents
| العنوان: | Genomic predictors of interindividual differences in response to DNA damaging agents |
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| المؤلفون: | Sanchita Bhattacharya, Emma Wang, J. Peter Svensson, James M. Bugni, Rebecca C. Fry, Chandni Valiathan, Charles A. Whittaker, Leona D. Samson, Brad J. Hogan |
| المصدر: | Genes & Development. 22:2621-2626 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Alkylating Agents, Methylnitronitrosoguanidine, Chromosomes, Human, Pair 21, DNA repair, DNA damage, Gene regulatory network, Gene Expression, Biology, medicine.disease_cause, Cell Line, DNA Glycosylases, Research Communication, Open Reading Frames, Transcription (biology), Gene expression, Genetics, medicine, Humans, Gene Regulatory Networks, DNA Modification Methylases, Gene, Genome, Human, Tumor Suppressor Proteins, DNA Repair Enzymes, Human genome, Carcinogenesis, DNA Damage, Mutagens, Developmental Biology |
| الوصف: | Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent. Computational models identified 48 genes with basal expression that predicts susceptibility with 94% accuracy. Modulating transcript levels for two member genes, MYH and C21ORF56, confirmed that their expression does indeed influence alkylation sensitivity. Many proteins encoded by these genes are interconnected in cellular networks related to human cancer and tumorigenesis. |
| تدمد: | 1549-5477 0890-9369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c027b6bce66ecb9815a97b87c7ed520Test https://doi.org/10.1101/gad.1688508Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c027b6bce66ecb9815a97b87c7ed520 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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