المؤلفون: Cohen, Joshua D., Li, Lu, Wang, Yuxuan, Thoburn, Christopher, Afsari, Bahman, Danilova, Ludmila, Douville, Christopher, Javed, Ammar A., Wong, Fay, Mattox, Austin, Hruban, Ralph H., Wolfgang, Christopher L., Goggins, Michael G., Dal Molin, Marco, Wang, Tian-Li, Roden, Richard, Klein, Alison P., Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Vogelstein, Joshua T., Browne, James D., Schoen, Robert E., Brand, Randall E., Tie, Jeanne, Gibbs, Peter, Wong, Hui-Li, Mansfield, Aaron S., Jen, Jin, Hanash, Samir M., Falconi, Massimo, Allen, Peter J., Zhou, Shibin, Bettegowda, Chetan, Diaz, Luis A., Tomasetti, Cristian, Kinzler, Kenneth W., Vogelstein, Bert, Lennon, Anne Marie, Papadopoulos, Nickolas

المساهمون: National Institutes of Health, Doris Duke Charitable Foundation, Commonwealth Fund, John Templeton Foundation, Lustgarten Foundation, Virginia and D.K. Ludwig Fund for Cancer Research, Billi and Bernie Marcus Foundation, Mayo Clinic Clinomics Program, Center for Individualized Medicine, Defense Sciences Office, DARPA

المصدر: Science ; volume 359, issue 6378, page 926-930 ; ISSN 0036-8075 1095-9203

الإتاحة: https://doi.org/10.1126/science.aar3247Test

المؤلفون: Le, Dung T, Durham, Jennifer N, Smith, Kellie N, Wang, Hao, Bartlett, Bjarne R, Aulakh, Laveet K, Lu, Steve, Kemberling, Holly, Wilt, Cara, Luber, Brandon S, Wong, Fay, Azad, Nilofer S, Rucki, Agnieszka A, Laheru, Dan, Donehower, Ross, Zaheer, Atif, Fisher, George A, Crocenzi, Todd S, Lee, James J, Greten, Tim F, Duffy, Austin G, Ciombor, Kristen K, Eyring, Aleksandra D, Lam, Bao H, Joe, Andrew, Kang, S Peter, Holdhoff, Matthias, Danilova, Ludmila, Cope, Leslie, Meyer, Christian, Zhou, Shibin, Goldberg, Richard M, Armstrong, Deborah K, Bever, Katherine M, Fader, Amanda N, Taube, Janis, Housseau, Franck, Spetzler, David, Xiao, Nianqing, Pardoll, Drew M, Papadopoulos, Nickolas, Kinzler, Kenneth W, Eshleman, James R, Vogelstein, Bert, Anders, Robert A, Diaz, Luis A

المصدر: Articles, Abstracts, and Reports

مصطلحات موضوعية: Adult, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Antigens, Neoplasm, Biomarkers, Tumor, Brain Neoplasms, Cell Cycle Checkpoints, Colorectal Neoplasms, DNA Mismatch Repair, Disease-Free Survival, Female, Humans, Male, Middle Aged, Mutation, Neoplastic Syndromes, Hereditary, Programmed Cell Death 1 Receptor, T-Lymphocytes, Young Adult, Oncology

وصف الملف: application/pdf

العلاقة: https://digitalcommons.psjhealth.org/publications/1341Test; https://digitalcommons.psjhealth.org/cgi/viewcontent.cgi?article=2333&context=publicationsTest

الإتاحة: https://digitalcommons.psjhealth.org/publications/1341Test
https://digitalcommons.psjhealth.org/cgi/viewcontent.cgi?article=2333&context=publicationsTest

المؤلفون: Li, Yuguo, Qiao, Yuan, Chen, Hanwei, Bai, Renyuan, Staedtke, Verena, Han, Zheng, Xu, Jiadi, Chan, Kannie W.Y., Yadav, Nirbhay, Bulte, Jeff W.M., Zhou, Shibin, van Zijl, Peter C.M., Liu, Guanshu

المساهمون: NIH, Virginia and D.K. Ludwig Fund for Cancer Research

المصدر: Magnetic Resonance in Medicine ; volume 79, issue 2, page 1001-1009 ; ISSN 0740-3194 1522-2594

الإتاحة: https://doi.org/10.1002/mrm.27014Test

المؤلفون: Le, Dung T., Durham, Jennifer N., Smith, Kellie N., Wang, Hao, Bartlett, Bjarne R., Aulakh, Laveet K., Lu, Steve, Kemberling, Holly, Wilt, Cara, Luber, Brandon S., Wong, Fay, Azad, Nilofer S., Rucki, Agnieszka A., Laheru, Dan, Donehower, Ross, Zaheer, Atif, Fisher, George A., Crocenzi, Todd S., Lee, James J., Greten, Tim F., Duffy, Austin G., Ciombor, Kristen K., Eyring, Aleksandra D., Lam, Bao H., Joe, Andrew, Kang, S. Peter, Holdhoff, Matthias, Danilova, Ludmila, Cope, Leslie, Meyer, Christian, Zhou, Shibin, Goldberg, Richard M., Armstrong, Deborah K., Bever, Katherine M., Fader, Amanda N., Taube, Janis, Housseau, Franck, Spetzler, David, Xiao, Nianqing, Pardoll, Drew M., Papadopoulos, Nickolas, Kinzler, Kenneth W., Eshleman, James R., Vogelstein, Bert, Anders, Robert A., Diaz, Luis A.

المساهمون: Commonwealth Fund, Lustgarten Foundation, Ludwig Institute for Cancer Research, Stand Up To Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, Swim Across America, The Banyan Gate Foundation

المصدر: Science ; volume 357, issue 6349, page 409-413 ; ISSN 0036-8075 1095-9203

الإتاحة: https://doi.org/10.1126/science.aan6733Test

المؤلفون: Zhou, Shibin

المصدر: Nature ; volume 536, issue 7614, page 33-34 ; ISSN 0028-0836 1476-4687

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/nature18915Test
https://www.nature.com/articles/nature18915.pdfTest
https://www.nature.com/articles/nature18915Test

المؤلفون: Cromm, Philipp M., Crews, Craig M., Mainolfi, Nello, Rasmusson, Tim, Poulikakos, Poulikos I., Zhang, Chao, Bollag, Gideon, Shokat, Kevan M., Rosen, Neal, Agianian, Bogos, Gavathiotis, Evripidis, Raina, Kanak, Durrant, David E., Morrison, Deborah K., Neklesa, Taavi K., Winkler, James D., Chang, F., Steelman, L. S., Lee, J. T., Shelton, J. G., Navolanic, P. M., Blalock, W. L., Franklin, R. A., McCubrey, J. A., Burslem, George M., Smith, Blake E., Lai, Ashton C., Jaime-Figueroa, Saul, McQuaid, Daniel C., Bondeson, Daniel P., Toure, Momar, Dong, Hanqing, Qian, Yimin, Wang, Jing, Crew, Andrew P., Hines, John, Sanchez, Jaquelyn N., Wang, Ton, Cohen, Mark S., Shelledy, PharmD, Lindsay, Roman, PharmD, BCOP, Danielle, Davies, Helen, Bignell, Graham R., Cox, Charles, Stephens, Philip, Edkins, Sarah, Clegg, Sheila, Teague, Jon, Woffendin, Hayley, Garnett, Mathew J., Bottomley, William, Davis, Neil, Dicks, Ed, Ewing, Rebecca, Floyd, Yvonne, Gray, Kristian, Hall, Sarah, Hawes, Rachel, Hughes, Jaime, Kosmidou, Vivian, Menzies, Andrew, Mould, Catherine, Parker, Adrian, Stevens, Claire, Watt, Stephen, Hooper, Steven, Jayatilake, Hiran, Gusterson, Barry A., Cooper, Colin, Shipley, Janet, Hargrave, Darren, Pritchard-Jones, Katherine, Maitland, Norman, Chenevix-Trench, Georgia, Riggins, Gregory J., Bigner, Darell D., Palmieri, Giuseppe, Cossu, Antonio, Flanagan, Adrienne, Nicholson, Andrew, Ho, Judy W.C., Leung, Suet Y., Yuen, Siu T., Weber, Barbara L., Seigler, Hilliard F., Darrow, Timothy L., Paterson, Hugh, Wooster, Richard, Stratton, Michael R., Futreal, P. Andrew, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A., Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L., Visor, Gary, Rezaei, Hamid, Lin, Paul S., Nolop, Keith, Ibrahim, Prabha N., Hirth, Peter, Arozarena, Imanol, Wellbrock, Claudia, Samatar, Ahmed A., Karoulia, Zoi, Chapman, Paul B., Hauschild, Axel, Robert, Caroline, Haanen, John B., Ascierto, Paolo, Larkin, James, Dummer, Reinhard, Garbe, Claus, Testori, Alessandro, Maio, Michele, Hogg, David, Lorigan, Paul, Lebbe, Celeste, Jouary, Thomas, Schadendorf, Dirk, Ribas, Antoni, O'Day, Steven J., Sosman, Jeffrey A., Kirkwood, John M., Eggermont, Alexander M.M., Dreno, Brigitte, Li, Jiang, Nelson, Betty, Hou, Jeannie, Lee, Richard J., Flaherty, Keith T., McArthur, Grant A., Vogelstein, Bert, Papadopoulos, Nickolas, Velculescu, Victor E., Zhou, Shibin, Diaz, Luis A., Kinzler, Kenneth W., Millington, G. W.M., Buhimschi, Alexandru D., Hamman, Brian D., Ishchenko, Alexey

المصدر: Cromm, P M, Crews, C M, Mainolfi, N, Rasmusson, T, Poulikakos, P I, Zhang, C, Bollag, G, Shokat, K M, Rosen, N, Crews, C M, Agianian, B, Gavathiotis, E, Raina, K, Crews, C M, Durrant, D E, Morrison, D K, Neklesa, T K, Winkler, J D, Crews, C M, Chang, F, Steelman, L S, Lee, J T, Shelton, J G, Navolanic, P M, Blalock, W L, Franklin, R A, McCubrey, J A, Burslem, G M, Smith, B E, Lai, A C, Jaime-Figueroa, S, McQuaid, D C, Bondeson, D P, Toure, M, Dong, H, Qian, Y, Wang, J, Crew, A P, Hines, J, Crews, C M, Sanchez, J N, Wang, T, Cohen, M S, Shelledy, PharmD, L, Roman, PharmD, BCOP, D, Davies, H, Bignell, G R, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, M J, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Jayatilake, H, Gusterson, B A, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, G J, Bigner, D D, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, J W C, Leung, S Y, Yuen, S T, Weber, B L, Seigler, H F, Darrow, T L, Paterson, H, Wooster, R, Wooster, R, Stratton, M R, Futreal, P A, Zhang, C, Spevak, W, Zhang, Y, Burton, E A, Ma, Y, Habets, G, Zhang, J, Lin, J, Ewing, T, Matusow, B, Tsang, G, Marimuthu, A, Cho, H, Wu, G, Wang, W, Fong, D, Nguyen, H, Shi, S, Womack, P, Nespi, M, Shellooe, R, Carias, H, Powell, B, Light, E, Sanftner, L, Walters, J, Tsai, J, West, B L, Visor, G, Rezaei, H, Lin, P S, Nolop, K, Ibrahim, P N, Hirth, P, Bollag, G, Arozarena, I, Wellbrock, C, Samatar, A A, Poulikakos, P I, Karoulia, Z, Gavathiotis, E, Poulikakos, P I, Chapman, P B, Hauschild, A, Robert, C, Haanen, J B, Ascierto, P, Larkin, J, Dummer, R, Garbe, C, Testori, A, Maio, M, Hogg, D, Lorigan, P, Lebbe, C, Jouary, T, Schadendorf, D, Ribas, A, O'Day, S J, Sosman, J A, Kirkwood, J M, Eggermont, A M M, Dreno, B, Nolop, K, Li, J, Nelson, B, Hou, J, Lee, R J, Flaherty, K T, McArthur, G A, Vogelstein, B, Papadopoulos, N, Velculescu, V E, Zhou, S, Diaz, L A, Kinzler, K W, Millington, G W M, Bondeson, D P, Smith, B E, Burslem, G M, Buhimschi, A D, Hines, J, Jaime-Figueroa, S, Wang, J, Hamman, B D, Ishchenko, A & Crews, C M 2018, ' The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study ', Cell Chemical Biology, pp. 67-77.e3 . https://doi.org/10.1016/j.chembiol.2017.09.009Test

مصطلحات موضوعية: 0301 basic medicine, Small molecular weight membrane-permeable inhibito, MAPK/p38, selective degradation, Raf kinases, Clinical Biochemistry, Receptor Protein-Tyrosine Kinases, protein-protein interactions, Signal transduction, Ligands, ERK cascade, protein dimerisation, Biochemistry, ternary complex, Receptor tyrosine kinase, Therapeutic intervention, 0302 clinical medicine, PROTACs, Drug Discovery, Kinome, Enzyme Inhibitors, Cereblon, E3 ligase, SNIPER, receptor tyrosine kinases, Manchester Cancer Research Centre, biology, Ras pathway, targeted degradation, Ubiquitin ligase, Raf inhibitors, 030220 oncology & carcinogenesis, Cytokines, cancer therapy, Molecular Medicine, Protein family, Ubiquitin-Protein Ligases, EGFR, hydrophobic tagging, Undruggable proteome, chemical biology, Protein degradation, Article, PROTAC, 03 medical and health sciences, proteomics, HER2, VHL, Humans, Molecular Biology, c-Met, Pharmacology, Heterobifunctional degrader, ResearchInstitutes_Networks_Beacons/mcrc, Proteolysis targeting chimera, Ubiquitination, Oncogenes, 030104 developmental biology, MAPK kinase cascade, CRBN, Proteolysis, biology.protein, Targeted protein degradation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361df2b1e3e643d7e80d0d128cb88ce3Test
https://doi.org/10.1016/j.chembiol.2017.09.009Test

المؤلفون: Perica, Karlo, Bieler, Joan Glick, Schütz, Christian, Varela, Juan Carlos, Douglass, Jacqueline, Skora, Andrew, Chiu, Yen Ling, Oelke, Mathias, Kinzler, Kenneth, Zhou, Shibin, Vogelstein, Bert, Schneck, Jonathan P.

المساهمون: National Institute of Allergy and Infectious Diseases, Sol Goldman Charitable Trust, HERA Women’s Cancer Foundation, Miltenyi Biotec, Commonwealth Fund, Deutsche Forschungsgemeinschaft, NexImmune, Inc., Virginia and D.K. Ludwig Fund for Cancer Research, Cancer Research Institute, National Institute of General Medical Sciences, Troper Wojcicki Foundation, National Cancer Institute

المصدر: ACS Nano ; volume 9, issue 7, page 6861-6871 ; ISSN 1936-0851 1936-086X

الإتاحة: https://doi.org/10.1021/acsnano.5b02829Test

المؤلفون: Cheong, Ian, Zhou, Shibin

المصدر: Methods in Enzymology ; page 251-265 ; ISSN 0076-6879

الإتاحة: https://doi.org/10.1016/s0076-6879Test(09)65013-8

المؤلفون: Chan, Kannie W.Y., Yu, Tao, Qiao, Yuan, Liu, Qiang, Yang, Ming, Patel, Himatkumar, Liu, Guanshu, Kinzler, Kenneth W., Vogelstein, Bert, Bulte, Jeff W.M., van Zijl, Peter C.M., Hanes, Justin, Zhou, Shibin, McMahon, Michael T.

المساهمون: The Virginia and D.K. Ludwig Fund for Cancer Research

المصدر: Journal of Controlled Release ; volume 180, page 51-59 ; ISSN 0168-3659

مصطلحات موضوعية: Pharmaceutical Science

الإتاحة: https://doi.org/10.1016/j.jconrel.2014.02.005Test
https://api.elsevier.com/content/article/PII:S0168365914000716?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168365914000716?httpAccept=text/plainTest

المؤلفون: Roberts, Nicholas J., Zhang, Linping, Janku, Filip, Collins, Amanda, Bai, Ren-Yuan, Staedtke, Verena, Rusk, Anthony W., Tung, David, Miller, Maria, Roix, Jeffrey, Khanna, Kristen V., Murthy, Ravi, Benjamin, Robert S., Helgason, Thorunn, Szvalb, Ariel D., Bird, Justin E., Roy-Chowdhuri, Sinchita, Zhang, Halle H., Qiao, Yuan, Karim, Baktiar, McDaniel, Jennifer, Elpiner, Amanda, Sahora, Alexandra, Lachowicz, Joshua, Phillips, Brenda, Turner, Avenelle, Klein, Mary K., Post, Gerald, Diaz, Luis A., Riggins, Gregory J., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Bettegowda, Chetan, Huso, David L., Varterasian, Mary, Saha, Saurabh, Zhou, Shibin

المصدر: Science Translational Medicine ; volume 6, issue 249 ; ISSN 1946-6234 1946-6242

الإتاحة: https://doi.org/10.1126/scitranslmed.3008982Test