المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent

المساهمون: INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: International audience ; Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels

العلاقة: hal-02625556; https://hal.inrae.fr/hal-02625556Test; https://hal.inrae.fr/hal-02625556/documentTest; https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest; PRODINRA: 476212; WOS: 000461151800061

الإتاحة: https://doi.org/10.1038/s41598-019-41101-8Test
https://hal.inrae.fr/hal-02625556Test
https://hal.inrae.fr/hal-02625556/documentTest
https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest

المؤلفون: Bonan, Natalia Borges, Schepers, Eva, Pecoits-Filho, Roberto, Dhondt, Annemieke, Pletinck, Anneleen, De Somer, Filip, Vanholder, Raymond, Van Biesen, Wim, Moreno-Amaral, Andrea, Glorieux, Griet

المصدر: SCIENTIFIC REPORTS ; ISSN: 2045-2322

مصطلحات موضوعية: Medicine and Health Sciences, Biology and Life Sciences, CD14(++)CD16(+) MONOCYTES, HEMODIALYSIS-PATIENTS, PERIPHERAL-BLOOD, P-CRESYLSULPHATE, PLATELETS, MICROINFLAMMATION, SUBPOPULATIONS, EXPRESSION, TOXICITY, SUBSETS

الوصف: Intermediate (CD14(++)CD16(+)) monocytes have important pro-inflammatory and atherogenic features and are increased in patients with chronic kidney disease (CKD). The present study aims to elucidate the role of the uremic milieu and of platelet activation in monocyte differentiation. Monocyte subtypes were analyzed in CKD patients (n = 193) and healthy controls (n = 27). Blood from healthy controls (Ctrl; n = 8) and hemodialysis patients (HD; n = 8) was centrifuged, and plasma (pl) was exchanged between Ctrl and HD (Ctrlcells/HDpl and HDcells/Ctrlpl) or reconstituted as original (Ctrlsham and HDsham) and incubated for 24 h (T24). Monocyte differentiation and platelet aggregation to monocytes (MPA) was assessed by flow cytometry. Especially, a higher proportion of CD14(++)CD16(+) monocytes was found in hemodialysis (HD) patients (p < 0.01). In plasma exchange experiments, Ctrl cells/HD pl T24 showed an increased percentage of CD14(++)CD16(+) monocytes versus Ctrl sham (33.7% +/- 15 vs. 15.7% +/- 9.6; P.< 0.005), comparable to the level of CD14(++)CD16(+) monocytes in the HD sham condition. The percentage of CD14(++)CD16(+) monocytes was lowered by suspending HD cells in Ctrl pl (18.4% +/- 7.8 vs. 36.7% +/- 15 in HD sham; P < 0.005) reaching the level of the Ctrl sham condition (15.7% +/- 9.6). A mixture of uremic sulfates increased CD14(++)CD16(+) monocytes compared to control (19.8 +/- 9.6% vs. 15.8 +/- 10.9%; P < 0.05), paralleled by a rise MPA. Blocking MPA by abciximab, a potential therapeutic strategy, or anti-CD62P did not inhibit differentiation towards the CD14(++)CD16(+) monocytes. In conclusion, in the present cohort, CD14(++)CD16(+) monocytes are especially increased in HD patients and this can at least in part be attributed to the presence of the uremic milieu, with uremic sulfates inducing a reversible shift towards pro-inflammatory CD14(++)CD16(+) monocytes.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8635572Test; http://hdl.handle.net/1854/LU-8635572Test; http://dx.doi.org/10.1038/s41598-019-46724-5Test; https://biblio.ugent.be/publication/8635572/file/8635574Test

الإتاحة: https://doi.org/10.1038/s41598-019-46724-5Test
https://biblio.ugent.be/publication/8635572Test
http://hdl.handle.net/1854/LU-8635572Test
https://biblio.ugent.be/publication/8635572/file/8635574Test

المؤلفون: Joossens, Marie, Faust, Karoline, Gryp, Tessa, Nguyen, Anh Thi Loan, Wang, Jun, Eloot, Sunny, Schepers, Eva, Dhondt, Annemieke, Pletinck, Anneleen, Vieira-Silva, Sara, Falony, Gwen, Vaneechoutte, Mario, Vanholder, Raymond, Van Biesen, Wim, Huys, Geert Roger Bertrand, Raes, Jeroen, Glorieux, Griet

المصدر: GUT ; ISSN: 0017-5749

مصطلحات موضوعية: Medicine and Health Sciences, Biology and Life Sciences

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8586983Test; http://hdl.handle.net/1854/LU-8586983Test; http://dx.doi.org/10.1136/gutjnl-2018-317561Test; https://biblio.ugent.be/publication/8586983/file/8586986Test

الإتاحة: https://doi.org/10.1136/gutjnl-2018-317561Test
https://biblio.ugent.be/publication/8586983Test
http://hdl.handle.net/1854/LU-8586983Test
https://biblio.ugent.be/publication/8586983/file/8586986Test

المؤلفون: Borges Bonan, Natalia, Schepers, Eva, Pecoits-Filho, Roberto, Dhondt, Annemieke, Pletinck, Anneleen, De Somer, Filip, Vanholder, Raymond, Van Biesen, Wim, Moreno-Amaral, Andréa, Glorieux, Griet

المصدر: Scientific Reports ; volume 9, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Intermediate (CD14 ++ CD16 + ) monocytes have important pro-inflammatory and atherogenic features and are increased in patients with chronic kidney disease (CKD). The present study aims to elucidate the role of the uremic milieu and of platelet activation in monocyte differentiation. Monocyte subtypes were analyzed in CKD patients (n = 193) and healthy controls (n = 27). Blood from healthy controls (Ctrl; n = 8) and hemodialysis patients (HD; n = 8) was centrifuged, and plasma (pl) was exchanged between Ctrl and HD (Ctrlcells/HDpl and HDcells/Ctrlpl) or reconstituted as original (Ctrlsham and HDsham) and incubated for 24 h (T24). Monocyte differentiation and platelet aggregation to monocytes (MPA) was assessed by flow cytometry. Especially, a higher proportion of CD14 ++ CD16 + monocytes was found in hemodialysis (HD) patients (p < 0.01). In plasma exchange experiments, Ctrl cells/HD pl T24 showed an increased percentage of CD14 ++ CD16 + monocytes versus Ctrl sham (33.7% ± 15 vs. 15.7% ± 9.6; P < 0.005), comparable to the level of CD14 ++ CD16 + monocytes in the HD sham condition. The percentage of CD14 ++ CD16 + monocytes was lowered by suspending HD cells in Ctrl pl (18.4% ± 7.8 vs. 36.7% ± 15 in HD sham; P < 0.005) reaching the level of the Ctrl sham condition (15.7% ± 9.6). A mixture of uremic sulfates increased CD14 ++ CD16 + monocytes compared to control (19.8 ± 9.6% vs. 15.8 ± 10.9%; P < 0.05), paralleled by a rise MPA. Blocking MPA by abciximab, a potential therapeutic strategy, or anti-CD62P did not inhibit differentiation towards the CD14 ++ CD16 + monocytes. In conclusion, in the present cohort, CD14 ++ CD16 + monocytes are especially increased in HD patients and this can at least in part be attributed to the presence of the uremic milieu, with uremic sulfates inducing a reversible shift towards pro-inflammatory CD14 ++ CD16 + monocytes.

الإتاحة: https://doi.org/10.1038/s41598-019-46724-5Test
https://www.nature.com/articles/s41598-019-46724-5.pdfTest
https://www.nature.com/articles/s41598-019-46724-5Test

المؤلفون: Verbeke, Francis, Siwy, Justyna, Van Biesen, Wim, Mischak, Harald, Pletinck, Anneleen, Schepers, Eva, Neirynck, Nathalie, Magalhães, Pedro, Pejchinovski, Martin, Pontillo, Claudia, Lichtinghagen, Ralf, Brand, Korbinian, Vlahou, Antonia, De Bacquer, Dirk, Glorieux, Griet

المساهمون: Research Foundation—Flanders

المصدر: Nephrology Dialysis Transplantation ; volume 36, issue 5, page 811-818 ; ISSN 0931-0509 1460-2385

مصطلحات موضوعية: Transplantation, Nephrology

الوصف: Background The urinary proteomic classifier chronic kidney disease 273 (CKD273) is predictive for the development and progression of chronic kidney disease (CKD) and/or albuminuria in type 2 diabetes. This study evaluates its role in the prediction of cardiovascular (CV) events in patients with CKD Stages G1–G5. Methods We applied the CKD273 classifier in a cohort of 451 patients with CKD Stages G1–G5 followed prospectively for a median of 5.5 years. Primary endpoints were all-cause mortality, CV mortality and the composite of non-fatal and fatal CV events (CVEs). Results In multivariate Cox regression models adjusting for age, sex, prevalent diabetes and CV history, the CKD273 classifier at baseline was significantly associated with total mortality and time to fatal or non-fatal CVE, but not CV mortality. Because of a significant interaction between CKD273 and CV history (P = 0.018) and CKD stages (P = 0.002), a stratified analysis was performed. In the fully adjusted models, CKD273 classifier was a strong and independent predictor of fatal or non-fatal CVE only in the subgroup of patients with CKD Stages G1–G3b and without a history of CV disease. In those patients, the highest tertile of CKD273 was associated with a >10-fold increased risk as compared with the lowest tertile. Conclusions The urinary CKD273 classifier provides additional independent information regarding the CV risk in patients with early CKD stage and a blank CV history. Determination of CKD273 scores on a random urine sample may improve the efficacy of intensified surveillance and preventive strategies by selecting patients who potentially will benefit most from early risk management.

الإتاحة: https://doi.org/10.1093/ndt/gfz242Test
http://academic.oup.com/ndt/article-pdf/36/5/811/37400443/gfz242.pdfTest

المؤلفون: Vanholder, Raymond, Pletinck, Anneleen, Schepers, Eva, Glorieux, Griet

المصدر: TOXINS ; ISSN: 2072-6651

مصطلحات موضوعية: Medicine and Health Sciences, CHRONIC KIDNEY-DISEASE, CHRONIC-RENAL-FAILURE, GLYCATION END-PRODUCTS, RETINOL-BINDING-PROTEIN, COLONY-STIMULATING FACTOR, ATRIAL-NATRIURETIC-PEPTIDE, CORONARY-ARTERY-DISEASE, FURAN, DICARBOXYLIC-ACID, TOXIN PHENYLACETIC ACID, NITRIC-OXIDE SYNTHASE, uremic toxins, uremic toxicity, uremia, Chronic Kidney Disease, CKD, cardiovascular disease, inflammation, fibrosis, patho-physiology CKD, middle molecules, protein bound uremic solutes, water-soluble uremic, solutes

الوصف: In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biological systems of the 11 considered. The inflammatory, cardio-vascular and fibrogenic systems were those most frequently affected and they are one by one major actors in the high morbidity and mortality of CKD but also the mechanisms that have most frequently been studied. A scoring system was built with the intention to classify the reviewed compounds according to the experimental evidence of their toxicity (number of systems affected) and overall experimental and clinical evidence. Among the highest globally scoring solutes were 3 small water-soluble compounds [asymmetric dimethylarginine (ADMA); trimethylamine-N-oxide (TMAO); uric acid], 6 protein bound compounds or groups of protein bound compounds [advanced glycation end products (AGEs); p-cresyl sulfate; indoxyl sulfate; indole acetic acid; the kynurenines; phenyl acetic acid;] and 3 middle molecules [(2)-microglobulin; ghrelin; parathyroid hormone). In general, more experimental data were provided for the protein bound molecules but for almost half of them clinical evidence was missing in spite of robust experimental data. The picture emanating is one of a complex disorder, where multiple factors contribute to a multisystem complication profile, so that it seems of not much use to pursue a decrease of concentration of a single compound.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8569371Test; http://hdl.handle.net/1854/LU-8569371Test; http://dx.doi.org/10.3390/toxins10010033Test; https://biblio.ugent.be/publication/8569371/file/8569372Test

الإتاحة: https://doi.org/10.3390/toxins10010033Test
https://biblio.ugent.be/publication/8569371Test
http://hdl.handle.net/1854/LU-8569371Test
https://biblio.ugent.be/publication/8569371/file/8569372Test

المؤلفون: Pletinck, Anneleen, Van Biesen, Wim, Dequidt, Clement, Eloot, Sunny

المصدر: BMC NEPHROLOGY ; ISSN: 1471-2369

مصطلحات موضوعية: Medicine and Health Sciences, PERITONEAL-DIALYSIS, ELECTRICAL-FIELD, PORE THEORY, PERMEABILITY, CAPD, PROTEINS, CHARGE, MEMBRANE, Peritoneal Dialysis, Transperitoneal membrane transport, Immunoglobulin, Three pore theory, Elektrokinetic model

الوصف: Background: It is debated whether transperitoneal membrane transport of larger (charged) molecules in peritoneal dialysis can be partially governed by the electrokinetic model. In this model, it is postulated that streaming potentials are generated across the capillary wall by forced filtration of an ionic solution, for example transcapillary ultrafiltration induced by osmotic forces as in peritoneal dialysis. We investigated the presence of streaming potentials in the process of transperitoneal transport in Peritoneal Dialysis (PD) patients by measuring ratios of dialysate concentrations of IgG2 (neutral) and IgG4 (negative), both 150kD, under different conditions of transcapillary ultrafiltration. Methods: Adult PD patients randomly got two consecutive dwells of 120 min each, with either 2 L Physioneal 1.36% or 3.86% glucose dialysis fluid (Baxter, USA) as their first dwell. A blood sample was taken at the test start, and dialysate samples were taken at 5, 15, 30, 60 and 120 min. IgG2 and IgG4 concentrations were measured (ELISA) and ratios calculated. Results: In 10 patients (65 +/- 17 years, 2017 months on dialysis), drained volume after 120 min was different between the 1.36% (1950 [1910; 2020] mL) and 3.86% (2540 [2380; 2800] mL) glucose dwells (P = 0.007). At none of the time points and irrespective of glucose concentration, a significant difference was found between the IgG2/IgG4 ratios at any time point. Conclusion: Our data failed to demonstrate a difference in the transport ratios of two macromolecules with same molecular weight but different charge, as would be expected by the electrokinetic model, and this despite sufficient differences in transcapillary ultrafiltration.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8581906Test; http://hdl.handle.net/1854/LU-8581906Test; http://dx.doi.org/10.1186/s12882-018-1104-1Test; https://biblio.ugent.be/publication/8581906/file/8581907Test

الإتاحة: https://doi.org/10.1186/s12882-018-1104-1Test
https://biblio.ugent.be/publication/8581906Test
http://hdl.handle.net/1854/LU-8581906Test
https://biblio.ugent.be/publication/8581906/file/8581907Test

المؤلفون: Delanghe, Sigurd, Van Biesen, Wim, Van de Velde, Nadeige, Eloot, Sunny, Pletinck, Anneleen, Schepers, Eva, Glorieux, Griet, Delanghe, Joris, Speeckaert, Marijn

المصدر: CLINICAL CHEMISTRY AND LABORATORY MEDICINE ; ISSN: 1434-6621

مصطلحات موضوعية: Medicine and Health Sciences, albumin, bromocresol green, bromocresol purple, carbamylation, para-cresyl sulfate, uremic toxins, CHRONIC KIDNEY-DISEASE, BOUND UREMIC SOLUTES, P-CRESYL SULFATE, SERUM-ALBUMIN, INDOXYL SULFATE, ALPHA-1-ACID GLYCOPROTEIN, PROTEIN CARBAMYLATION, ENDOGENOUS LIGANDS, RENAL-FAILURE, TOXINS

الوصف: BACKGROUND: Colorimetric albumin assays based on binding to bromocresol purple (BCP) and bromocresol green (BCG) yield different results in chronic kidney disease. Altered dye binding of carbamylated albumin has been suggested as a cause. In the present study, a detailed analysis was carried out in which uremic toxins, acute phase proteins and Kt/V, a parameter describing hemodialysis efficiency, were compared with colorimetrically assayed (BCP and BCG) serum albumin. METHODS: Albumin was assayed using immunonephelometry on a BN II nephelometer and colorimetrically based on, respectively, BCP and BCG on a Modular P analyzer. Uremic toxins were assessed using high-performance liquid chromatography. Acute phase proteins (C-reactive protein and α1-acid glycoprotein) and plasma protein α2-macroglobulin were assayed nephelometrically. In parallel, Kt/V was calculated. RESULTS: Sixty-two serum specimens originating from hemodialysis patients were analyzed. Among the uremic toxins investigated, total para-cresyl sulfate (PCS) showed a significant positive correlation with the BCP/BCG ratio. The serum α1-acid glycoprotein concentration correlated negatively with the BCP/BCG ratio. The BCP/BCG ratio showed also a negative correlation with Kt/V. CONCLUSIONS: In renal insufficiency, the BCP/BCG ratio of serum albumin is affected by multiple factors: next to carbamylation, uremic toxins (total PCS) and α1-acid glycoprotein also play a role.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8542865Test; http://hdl.handle.net/1854/LU-8542865Test; http://dx.doi.org/10.1515/cclm-2017-0444Test; https://biblio.ugent.be/publication/8542865/file/8542866Test

الإتاحة: https://doi.org/10.1515/cclm-2017-0444Test
https://biblio.ugent.be/publication/8542865Test
http://hdl.handle.net/1854/LU-8542865Test
https://biblio.ugent.be/publication/8542865/file/8542866Test

المؤلفون: Joossens, Marie, Faust, Karoline, Gryp, Tessa, Nguyen, Anh Thi Loan, Wang, Jun, Eloot, Sunny, Schepers, Eva, Dhondt, Annemieke, Pletinck, Anneleen, Vieira-Silva, Sara, Falony, Gwen, Vaneechoutte, Mario, Vanholder, Raymond, Van Biesen, Wim, Huys, Geert Roger Bertrand, Raes, Jeroen, Glorieux, Griet

المساهمون: Fonds Wetenschappelijk Onderzoek

المصدر: Gut ; volume 68, issue 12, page 2257.1-2260 ; ISSN 0017-5749 1468-3288

الإتاحة: https://doi.org/10.1136/gutjnl-2018-317561Test