المؤلفون: Bruschi, Barbara, Cantino, Valter, Cavallo Perin, Roberto, Culasso, Francesca, Giors, Barbara, Marchisio, Marina, Marello, Matteo, Operti, Lorenza, Parola, Alberto, Rabellino, Sergio, Sacchet, Matteo, Scomparin, Laura

المصدر: International Association for Development of the Information Society. 2018.

تمت مراجعته من قبل الزملاء: Y

Page Count: 6

الواصفات: Online Courses, Models, College Bound Students, High School Graduates, Foreign Countries, College Freshmen, Electronic Learning, Open Educational Resources, College Faculty

مصطلحات جغرافية: Italy

مستخلص: Students need help in transitioning from high school to university. It's important to facilitate their guidance in choosing the course of study and consequently their experience with the first exams, reducing the abandonment. The University of Turin, financially supported by the banking institution Compagnia di San Paolo, has invested in e-learning creating Start@unito: a Learning Management System that delivers twenty freely available, self-paced, online courses on different topics. The paper discusses the model adopted by Start@unito and the first results obtained. [For the complete proceedings, see ED600498.]

Abstractor: As Provided

المؤلفون: Roberto Gnavi, Veronica Sciannameo, Francesca Baratta, Cecilia Scarinzi, Marco Parente, Massimo Mana, Mario Giaccone, Paolo Cavallo Perin, Giuseppe Costa, Teresa Spadea, Paola Brusa

المصدر: PLoS ONE, Vol 15, Iss 3, p e0229842 (2020)

مصطلحات موضوعية: Medicine, Science

الوصف: BACKGROUND AND AIMS:Given the paucity of symptoms in the early stages of type 2 diabetes, its diagnosis is often made when complications have already arisen. Although systematic population-based screening is not recommended, there is room to experience new strategies for improving early diagnosis of the disease in high risk subjects. We report the results of an opportunistic screening for diabetes, implemented in the setting of community pharmacies. METHODS AND RESULTS:To identify people at high risk to develop diabetes, pharmacists were trained to administer FINDRISC questionnaire to overweight, diabetes-free customers aged 45 or more. Each interviewee was followed for 365 days, searching in the administrative database whether he/she had a glycaemic or HbA1c test, or a diabetologists consultation, and to detect any new diagnosis of diabetes defined by either a prescription of any anti-hyperglycaemic drug, or the enrolment in the register of patients, or a hospital discharge with a diagnosis of diabetes. Out of 5977 interviewees, 53% were at risk of developing diabetes. An elevated FINDRISC score was associated with higher age, lower education, and living alone. Excluding the number of cases expected, based on the incidence rate of diabetes in the population, 51 new cases were identified, one every 117 interviews. FINDRISC score, being a male and living alone were significantly associated with the diagnosis. CONCLUSIONS:The implementation of a community pharmacy-based screening programme can contribute to reduce the burden of the disease, particularly focusing on people at higher risk, such as the elderly and the socially vulnerable.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/173210bda2bf46318f261702d370b1b6Test

المؤلفون: Ornella Bosco, Barbara Vizio, Gabriella Gruden, Martina Schiavello, Bartolomeo Lorenzati, Paolo Cavallo-Perin, Isabella Russo, Giuseppe Montrucchio, Enrico Lupia

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 13, p 7032 (2021)

مصطلحات موضوعية: type 1 diabetes mellitus, platelet–leukocyte adhesion, platelet activation markers, thrombopoietin, atherosclerotic cardiovascular diseases, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in patients with type 1 diabetes mellitus (T1DM). Enhanced platelet reactivity is considered a main determinant of the increased atherothrombotic risk of diabetic patients. Thrombopoietin (THPO), a humoral growth factor able to stimulate megakaryocyte proliferation and differentiation, also modulates the response of mature platelets by enhancing both activation and binding to leukocytes in response to different agonists. Increased THPO levels have been reported in different clinical conditions characterized by a generalized pro-thrombotic state, from acute coronary syndromes to sepsis/septic shock, and associated with elevated indices of platelet activation. To investigate the potential contribution of elevated THPO levels in platelet activation in T1DM patients, we studied 28 T1DM patients and 28 healthy subjects. We measured plasma levels of THPO, as well as platelet-leukocyte binding, P-selectin, and THPO receptor (THPOR) platelet expression. The priming activity of plasma from diabetic patients or healthy subjects on platelet–leukocyte binding and the role of THPO on this effect was also studied in vitro. T1DM patients had higher circulating THPO levels and increased platelet–monocyte and platelet–granulocyte binding, as well as platelet P-selectin expression, compared to healthy subjects, whereas platelet expression of THPOR did not differ between the two groups. THPO concentrations correlated with platelet–leukocyte binding, as well as with fasting glucose and Hb1Ac. In vitro, plasma from diabetic patients, but not from healthy subjects, primed platelet–leukocyte binding and platelet P-selectin expression. Blocking THPO biological activity using a specific inhibitor prevented the priming effect induced by plasma from diabetic patients. In conclusion, augmented THPO may enhance platelet activation in patients with T1DM, potentially participating in increasing atherosclerotic risk.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/22/13/7032Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/fb350dc4a64449e1bdb4e8969d7c73a9Test

المؤلفون: Dario Casalini, Roberto Cavallo Perin

المصدر: Water, Vol 2, Iss 3, Pp 429-438 (2010)

مصطلحات موضوعية: public domain, water rights, concession, water markets, Hydraulic engineering, TC1-978, Water supply for domestic and industrial purposes, TD201-500

الوصف: Water resources in European legal systems have always been vested in sovereign power, regardless of their legal nature as goods vested in State property or as res communes omnium not subject to ownership. The common legal foundation of sovereign power over water resources departed once civil law jurisdictions leveled the demesne on ownership model, by introducing public ownership in the French codification of 1804, while common law jurisdiction developed a broader legal concept of property that includes even the rights to use res communes. The models led respectively to the establishment of administrative systems of water rights and markets of water rights. According to the first, public authorities’ power to manage and preserve water resources is grounded in a derogatory regime, whereby water rights, grounded on licenses or concessions, are neither transferable nor tradeable. On the contrary, environmental and social concerns in water market schemes must be enforced by means of regulation, thus limiting private property rights on water, in compliance with the constitutional and common law constraints set out to protect the minimum content of property as a fundamental human right.

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/2073-4441/2/3/429Test/; https://doaj.org/toc/2073-4441Test

الوصول الحر: https://doaj.org/article/0d71a723fbda483e8fb13daa12ff342bTest

المؤلفون: Graziella Bruno, Federica Barutta, Andrea Landi, Paolo Cavallo Perin, Gabriella Gruden

المصدر: PLoS ONE, Vol 9, Iss 5, p e96076 (2014)

مصطلحات موضوعية: Medicine, Science

الوصف: BACKGROUND: Among people with type 2 diabetes the relationship between central obesity and cardiovascular mortality has not been definitely assessed. Moreover, NT-proBNP is negatively associated with central obesity, but no study has examined their combined effect on survival. We have examined these issues in a well-characterized population-based cohort. METHODS AND FINDINGS: Survival data of 2272 diabetic people recruited in 2000 who had no other chronic disease have been updated to 31 December 2006. NT-proBNP was measured in a subgroup of 1690 patients. Cox proportional hazards modeling was employed to estimate the independent associations between cardiovascular and all-cause mortality and waist circumference. Mean age was 67.9 years, 49.3% were men. Both age and NT-proBNP were negatively correlated with waist circumference (r = -0.11, p

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4006893?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/f511d43cfe1841baa83cca05985d0598Test

المؤلفون: Graziella Bruno, Federica Barutta, Andrea Landi, Paolo Cavallo Perin, Gabriella Gruden

المصدر: PLoS ONE, Vol 9, Iss 12, p e114855 (2014)

مصطلحات موضوعية: Medicine, Science

الوصف: Few data are available to assess whether a low-moderate reduction in estimated glomerular filtration rates (eGFR) has a role per se on cardiovascular (CV) mortality or other biomarkers such as NT-proBNP allow to explain such association.In a prospective study including 1,645 type 2 diabetic subjects of the population-based Casale Monferrato Study, who had no clinical evidence of heart failure and eGFR >45 ml/min/1.73 m2, we examined 6 years CV mortality. Multivariate Cox proportional hazards modeling were used to estimate the effect of NT-proBNP on the association between eGFR and mortality, independently of baseline CV risk factors, albumin excretion rate (AER) and C-reactive protein (CRP). During follow-up, 327 people died (149 of CV diseases) out of 8334.5 person-years. Compared to eGFR≥90 ml/min/1.73 m2, values of 60-89 and 45-59 ml/min/1.73 m2 conferred a fully adjusted hazard ratios (HRs) of CV mortality of 1.74 (1.08-2.82) and 1.95 (1.03-3.68), respectively. After further adjustment for NT-proBNP, however, HRs were no longer significant (HRs 1.42, 0.83-2.42 and 1.22, 0.59-2.51). In this model, HR for logNT-proBNP was 1.84 (1.52-2.22). Adding NT-proBNP to the model improved the C-statistic of CV mortality from 0.79 (0.76-0.83) to 0.84 (0.81-0.87), yielded an IDI of 0.03 (p = 0.02), and a NRI of 0.44 (p = 0.016).In diabetic people a modest reduction in renal function increased 6-year CV mortality independently of albuminuria. This association, however, was mainly explained by the effect of NT-proBNP, that remained the strongest prognostic marker for a worse CV outcome, even after adjustment for other CV risk factors and pre-existing CVD.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4263725?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/34a8ea9f7a4b466ba4e4d97a29a5d346Test

المؤلفون: A. Pilotto, M. Noale, S. Maggi, F. Addante, A. Tiengo, P. Cavallo Perin, G. Rengo, G. Crepaldi

المصدر: BioMed Research International, Vol 2014 (2014)

مصطلحات موضوعية: Medicine

الوصف: Aim. To identify the characteristics associated with multidimensional impairment, evaluated through the Multidimensional Prognostic Index (MPI), a validated predictive tool for mortality derived from a standardized Comprehensive Geriatric Assessment (CGA), in a cohort of elderly diabetic patients treated with oral hypoglycemic drugs. Methods and Results. The study population consisted of 1342 diabetic patients consecutively enrolled in 57 diabetes centers distributed throughout Italy, within the Metabolic Study. Inclusion criteria were diagnosis of type 2 diabetes mellitus (DM), 65 years old or over, and treatment with oral antidiabetic medications. Data concerning DM duration, medications for DM taken during the 3-month period before inclusion in the study, number of hypoglycemic events, and complications of DM were collected. Multidimensional impairment was assessed using the MPI evaluating functional, cognitive, and nutritional status; risk of pressure sores; comorbidity; number of drugs taken; and cohabitation status. The mean age of participants was 73.3 ± 5.5 years, and the mean MPI score was 0.22 ± 0.13. Multivariate analysis showed that advanced age, female gender, hypoglycemic events, and hospitalization for glycemic decompensation were independently associated with a worse MPI score. Conclusion. Stratification of elderly diabetic patients using the MPI might help to identify those patients at highest risk who need better-tailored treatment.

العلاقة: http://dx.doi.org/10.1155/2014/906103Test; https://doaj.org/toc/2314-6133Test; https://doaj.org/toc/2314-6141Test; https://doaj.org/article/66cb039e41f042e8942e2396f35679b1Test

الإتاحة: https://doi.org/10.1155/2014/906103Test
https://doaj.org/article/66cb039e41f042e8942e2396f35679b1Test

المؤلفون: Federica Barutta, Marinella Tricarico, Alessandro Corbelli, Laura Annaratone, Silvia Pinach, Serena Grimaldi, Graziella Bruno, Daniela Cimino, Daniela Taverna, Maria Chiara Deregibus, Maria Pia Rastaldi, Paolo Cavallo Perin, Gabriella Gruden

المصدر: PLoS ONE, Vol 8, Iss 11, p e73798 (2013)

مصطلحات موضوعية: Medicine, Science

الوصف: MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Results showed that miR-130a and miR-145 were enriched, while miR-155 and miR-424 reduced in urinary exosomes from patients with microalbuminuria. Similarly, in an animal model of early experimental diabetic nephropathy, urinary exosomal miR-145 levels were increased and this was paralleled by miR-145 overexpression within the glomeruli. Exposure of cultured mesangial cells to high glucose increased miR-145 content in both mesangial cells and mesangial cells-derived exosomes, providing a potential mechanism for diabetes-induced miR-145 overexpression. In conclusion, urinary exosomal miRNA content is altered in type 1 diabetic patients with incipient diabetic nephropathy and miR-145 may represent a novel candidate biomarker/player in the complication.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3817183?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/b5c03c816c7e410fa9a3d0e2b7cb9abfTest

المؤلفون: R., Mallone, E., Ortolan, S., Pinach, M., Volante, M., Zanone, G., Bruno, G., Baj, T., Lohmann, P., Cavallo-Perin, F., Malavasi

المصدر: Diabetologia ; volume 45, issue 12, page 1667-1677 ; ISSN 0012-186X 1432-0428

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1007/s00125-002-0940-4Test

المؤلفون: G. Penno, A. Solini, C. Fondelli, E. Bonora, G. Zerbini, E. Orsi, R. Trevisan, A. Avogaro, P. Cavallo Perin, M. Trovati, M. Cignarelli, L. Laviola, MORANO, Susanna, PUGLIESE, Giuseppe

المساهمون: G., Penno, A., Solini, C., Fondelli, E., Bonora, G., Zerbini, E., Orsi, R., Trevisan, A., Avogaro, P., Cavallo Perin, M., Trovati, M., Cignarelli, L., Laviola, Morano, Susanna, Pugliese, Giuseppe

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000266352603219; 69th Annual Meeting of the American-Diabetes-Association; volume:58; firstpage:A562; lastpage:A562; numberofpages:1; journal:DIABETES; http://hdl.handle.net/11573/492998Test

الإتاحة: http://hdl.handle.net/11573/492998Test