المؤلفون: Schramm, Moritz W. J., Sheikh, Asim J., Chave-Cox, Rebecca, McQuaid, James, Whitty, Rachel C. W., Ilyinskaya, Evgenia

المصدر: Acta Neurochirurgica ; volume 163, issue 7, page 1819-1827 ; ISSN 0001-6268 0942-0940

مصطلحات موضوعية: Neurology (clinical), Surgery

الوصف: Background Aerosol is a health risk to theatre staff. This laboratory study quantifies the reduction in particulate matter aerosol concentrations produced by electrocautery and drilling when using mitigation strategies such as irrigation, respirator filtration and suction in a lab environment to prepare for future work under live OR conditions. Methods We combined one aerosol-generating procedure (monopolar cutting or coagulating diathermy or high-speed diamond- or steel-tipped drilling of cadaveric porcine tissue) with one or multiple mitigation strategies (instrument irrigation, plume suction and filtration using an FFP3 respirator filter) and using an optical particle counter to measure particulate matter aerosol size and concentrations. Results Significant aerosol concentrations were observed during all aerosol-generating procedures with concentrations exceeding 3 × 10 6 particles per 100 ml. Considerable reductions in concentrations were observed with mitigation. In drilling, suction, FFP3 filtration and wash alone respectively reduced aerosol by 19.3–31.6%, 65.1–70.8% and 97.2 to > 99.9%. The greatest reduction (97.38 to > 99.9%) was observed when combining irrigation and filtration. Coagulating diathermy reduced concentrations by 88.0–96.6% relative to cutting, but produced larger particles. Suction alone, and suction with filtration reduced aerosol concentration by 41.0–49.6% and 88.9–97.4% respectively. No tested mitigation strategies returned aerosol concentrations to baseline. Conclusion Aerosol concentrations are significantly reduced through the combined use of filtration, suction and irrigation. Further research is required to characterise aerosol concentrations in the live OR and to find acceptable exposure limits, and in their absence, to find methods to further reduce exposure to theatre staff.

الإتاحة: https://doi.org/10.1007/s00701-021-04874-4Test

المؤلفون: Schramm, Moritz W. J., Sheikh, Asim J., Chave-Cox, Rebecca, McQuaid, James, Whitty, Rachel C. W., Ilyinskaya, Evgenia

المصدر: Acta Neurochir (Wien)

مصطلحات موضوعية: Original Article - Neurosurgery general, envir, geo

الوصف: BACKGROUND: Aerosol is a health risk to theatre staff. This laboratory study quantifies the reduction in particulate matter aerosol concentrations produced by electrocautery and drilling when using mitigation strategies such as irrigation, respirator filtration and suction in a lab environment to prepare for future work under live OR conditions. METHODS: We combined one aerosol-generating procedure (monopolar cutting or coagulating diathermy or high-speed diamond- or steel-tipped drilling of cadaveric porcine tissue) with one or multiple mitigation strategies (instrument irrigation, plume suction and filtration using an FFP3 respirator filter) and using an optical particle counter to measure particulate matter aerosol size and concentrations. RESULTS: Significant aerosol concentrations were observed during all aerosol-generating procedures with concentrations exceeding 3 × 10(6) particles per 100 ml. Considerable reductions in concentrations were observed with mitigation. In drilling, suction, FFP3 filtration and wash alone respectively reduced aerosol by 19.3–31.6%, 65.1–70.8% and 97.2 to > 99.9%. The greatest reduction (97.38 to > 99.9%) was observed when combining irrigation and filtration. Coagulating diathermy reduced concentrations by 88.0–96.6% relative to cutting, but produced larger particles. Suction alone, and suction with filtration reduced aerosol concentration by 41.0–49.6% and 88.9–97.4% respectively. No tested mitigation strategies returned aerosol concentrations to baseline. CONCLUSION: Aerosol concentrations are significantly reduced through the combined use of filtration, suction and irrigation. Further research is required to characterise aerosol concentrations in the live OR and to find acceptable exposure limits, and in their absence, to find methods to further reduce exposure to theatre staff.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143442Test/

الإتاحة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143442Test/

المؤلفون: Chave-Cox, Rebecca S.

المصدر: Journal of Forensic and Legal Medicine ; volume 25, page 71-75 ; ISSN 1752-928X

مصطلحات موضوعية: Law, General Medicine, Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1016/j.jflm.2014.04.010Test
https://api.elsevier.com/content/article/PII:S1752928X14000730?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1752928X14000730?httpAccept=text/plainTest

المؤلفون: Islim, Abdurrahman I, Millward, Christopher P, Piper, Rory J, Fountain, Daniel M, Mehta, Shaveta, Kolamunnage-Dona, Ruwanthi, Ali, Usama, Koszdin, Shelli Diane, Georgious, Theo, Mills, Samantha J, Brodbelt, Andrew R, Mathew, Ryan K, Santarius, Thomas, Jenkinson, Michael D, Mohamed Abdelsadg, Suhaib Abualsaud, Amro Abuleil, Kevin Agyemang, Hanan Akbari, Likhith Alakandy, Erminia Albanese, Clarissa Alfonso, Usama Ali, Arousa Ali, Tamara Ali, Michael Amoo, Mohamed A R Arbab, Mutiu Asha, Kareem Austin, Khaled Badran, Jarnail Bal, Chris Barrett, Parameswaran Bhattathiri, Paul M Brennan, Andrew R Brodbelt, Jennifer Brown, Daniel Brown, Ferran Brugada-Bellsolà, Placido Bruzzaniti, Annabel Butcher, Rory S Cairns, Michael Canty, Michael Cearns, Sachiv Chakravarti, Rebecca Chave-Cox, Yasir Chowdhury, Anna Craig-McQuade, Giles Critchley, Peter Crossley, Elizabeth Culpin, Alessia D'Amico, Bassam Dabbous, Pedro David Delgado-López, Mohamed Draz, Katharine J Drummond, Rusiru T Ekanayaka, Muhammed Elhadi, Ibrahim Elmaadawi, Omar Elmandouh, Mazin Elsharif, Daisy Evans, Andreas Fahlström, Pietro Familiari, Fleur L Fisher, Bryony Ford, Daniel M Fountain, Keiko Fox, Francesco Gaillard, Chloé Gelder, Theo Georgious, Shamayitri Ghosh, Aimee Goel, Melissa Gough, Athanasios Grivas, Andrew Gvozdanovic, Allan Hall, Hytham Hamid, Liv Hartrick, Samih Hassan, Jack Henry, Damian Holliman, Abdurrahman I Islim, Asgeir S Jakola, Mohsen Javadpour, Michael D Jenkinson, Sanjeeva Jeyaretna, Adrian Jimenez, Josephine Jung, Andranik Kahramanian, Neeraj Kalra, David O Kamson, Oliver Kennion, Adham M Khalafallah, Sarah Kingdon, Ruwanthi Kolamunnage-Dona, Shelli Diane Koszdin, Howra Ktayen, Aditaya Kumar, Simon Lammy, Pierfrancesco Lapolla, Jun Yi Lau, Jing Xian Lee, Ryan Leyden, Patricia Littlechild, Sophie Liu, Darmanin Lora-Kay, Vivia Lung, Stephen T Magill, Hani J Marcus, Fawaz E Marhoom, Javier Martin-Alonso, Ryan K Mathew, Calan Mathieson, Nathan McSorley, Tobias Mederer, Shaveta Mehta, Torstien R Meling, Samantha J Mills, Christopher P Millward, Andrea Mingoli, Mujtaba Mohammad, Debraj Mukherjee, Amir H Zamanipoor Najafabadi, Olivia Näslund, Minh Nguyen, Imran Noorani, Gildas Patet, Omar N Pathmanaban, Andrea Perera, Amit Persad, See Yung Phang, Rory J Piper, Jonathan Pollock, Benjamin Price, Martin Proescholdt, Richard Pullicino, James Robins, Ola Rominiyi, David Rowland, Bobby Sachdev, Fozia Saeed, Mahmoud Saleh, Thomas Santarius, Antonio Santoro, Ieva Sataite, Antony Kevin Scafa, Verena Schadewaldt, Syed Wajahat Shah, Mustafa El Sheikh, Zenab Sher, Bente Sandvei Skeie, Alexander Smedley, Agbolahan Sofela, Jerome St George, Torbjørn Strømsnes, Nigel Suttner, William Taylor, Philip Theodosopoulos, Elliot Tilling, Manjul Tripathi, Ismail Ughratdar, James Ulrich, Adithya Varma, Anil Varma, Maria Velicu, Sara Venturini, Esther Wu, Jacob Young, Giuseppa Zancana, Catherine Zhang, Karolyn Au, Jill Barnholtz-Sloan, Felix Behling, Linda Bi, Priscilla Brastianos, Chaya Brodie, Nicholas Butowski, Ana Castro, Aaron Cohen-Gadol, Marta Couce, Francesco Dimeco, Katherine J Drummond, Ian Dunn, Craig Erker, Michelle Felicella, Eva Galanis, Norbert Galldiks, Caterina Giannini, Roland Goldbrunner, Oliver Hanemann, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Raymond Huang, Christine Jungk, Gerhard Jungwirth, Timothy Kaufmann, Boris Krischek, Sylvia Kurz, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Tiit Illimar Mathiesen, Christian Mawrin, Michael McDermott, Jennifer Moliterno-Gunel, Andrew Morokoff, Farshad Nassiri, H K Ng, Houtan Noushmehr, Arie Perry, Laila Poisson, Bianco Pollo, Aditya Ragunathan, David Raleigh, Mirjam Renovanz, Franz Ricklefs, Felix Sahm, Andrea Saladino, Antonio Santacroce, Christian Schichor, Nils Schimdt, Jens Schittenhelm, Warren Selman, Helen Shih, Andrew Sloan, Matija Snuderl, Jim Snyder, Erik Sulman, Suganth Suppiah, Ghazaleh Tabatabai, Marcos Tatagiba, Marco Timmer, Jorg-Christian Tonn, Michael Vogelbaum, Andreas Von Deimling, Tobias Walbert, Simon Walling, Justin Z Wang, Patrick Wen, Manfred Westphal, Stephen Yip, Gabriel Zada, Gelareh Zadeh, Viktor Zherebitskiy, Michael T C Poon, Angelos Kolias, Julie Woodfield, Rory Piper, Aswin Chari

المساهمون: Abdurrahman I, Islim, Christopher P, Millward, Rory J, Piper, Daniel M, Fountain, Shaveta, Mehta, Ruwanthi, Kolamunnage-Dona, Usama, Ali, Shelli Diane, Koszdin, Theo, Georgiou, Samantha J, Mill, Andrew R, Brodbelt, Ryan K, Mathew, Thomas, Santariu, Jenkinson, D, Michael, Abdelsadg, Mohamed, Abualsaud, Suhaib, Abuleil, Amro, Agyemang, Kevin, Akbari, Hanan, Alakandy, Likhith, Albanese, Erminia, Alfonso, Clarissa, Ali, Usama, Ali, Arousa, Ali, Tamara, Amoo, Michael, R Arbab, Mohamed A, Asha, Mutiu, Austin, Kareem, Badran, Khaled, Bal, Jarnail, Barrett, Chri, Bhattathiri, Parameswaran, M Brennan, Paul, R Brodbelt, Andrew, Brown, Jennifer, Brown, Daniel, Brugada-Bellsolà, Ferran, Bruzzaniti, Placido, Butcher, Annabel, S Cairns, Rory, Canty, Michael, Cearns, Michael, Chakravarti, Sachiv, Chave-Cox, Rebecca, Chowdhury, Yasir, Craig-McQuade, Anna, Critchley, Gile, Crossley, Peter, Culpin, Elizabeth, D'Amico, Alessia, Dabbous, Bassam, David Delgado-López, Pedro, Draz, Mohamed, J Drummond, Katharine, T Ekanayaka, Rusiru, Elhadi, Muhammed, Elmaadawi, Ibrahim, Elmandouh, Omar, Elsharif, Mazin, Evans, Daisy, Fahlström, Andrea, Familiari, Pietro, L Fisher, Fleur, Ford, Bryony, M Fountain, Daniel, Fox, Keiko, Gaillard, Francesco, Gelder, Chloé, Georgious, Theo, Ghosh, Shamayitri, Goel, Aimee, Gough, Melissa, Grivas, Athanasio, Gvozdanovic, Andrew, Hall, Allan, Hamid, Hytham, Hartrick, Liv, Hassan, Samih, Henry, Jack, Holliman, Damian, I Islim, Abdurrahman, S Jakola, Asgeir, Javadpour, Mohsen, D Jenkinson, Michael, Jeyaretna, Sanjeeva, Jimenez, Adrian, Jung, Josephine, Kahramanian, Andranik, Kalra, Neeraj, O Kamson, David, Kennion, Oliver, M Khalafallah, Adham, Kingdon, Sarah, Kolamunnage-Dona, Ruwanthi, Diane Koszdin, Shelli, Ktayen, Howra, Kumar, Aditaya, Lammy, Simon

مصطلحات موضوعية: neurological oncology, neuroradiology, neurosurgery, oncology

الوصف: Introduction: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. Methods and analysis: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. Ethics and dissemination: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-reviewed articles and conferences and disseminated ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35042706; info:eu-repo/semantics/altIdentifier/wos/WOS:000753380800001; volume:12; issue:1; numberofpages:9; journal:BMJ OPEN; http://hdl.handle.net/11573/1604639Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123660462

الإتاحة: https://doi.org/10.1136/bmjopen-2021-052705Test
http://hdl.handle.net/11573/1604639Test