المؤلفون: Hostettler, Isabel Charlotte, Morton, Matthew J, Ambler, Gareth, Kazmi, Nabila, Gaunt, Tom, Wilson, Duncan, Shakeshaft, Clare, Jäger, H R, Cohen, Hannah, Yousry, Tarek A, Al-Shahi Salman, Rustam, Lip, Gregory, Brown, Martin M, Muir, Keith, Houlden, Henry, Bulters, Diederik O, Galea, Ian, Werring, David J, On behalf of the CROMIS-2 collaborators, Aeron-Thomas, John, Aghoram, Prasanna, Amis, Elaine, Anderton, Peter, Andole, Sreeman, Anwar, Ijaz, Bamford, John, Banaras, Azra, Barry, Aian, Bellfied, Ruth, Benford, Aienne, Bhalla, Ajay, Bhargava, Maneesh, Bhaskaran, Biju, Bhupathiraju, Neelima, Birns, Jonathan, Blight, Aian, Bowring, Angie, Brown, Ellen, Bruce, David, Buck, Amanda, Bunworth, Kerry, Burger, Ilse, Burgess, Laura, Burn, Mathew, Burssens, Evelyn, Burton, Mauian, Butler, Nicola, Button, Denise, Carpenter, Michael, Chadha, Dinesh, Chatterjee, Kausik, Choy, Lillian, Cohen, David, Connell, Lynne, Cooper, Martin, Corrigan, John, Cotterill, Donna, Courtauld, Gillian, Crawford, Susan, Cullen, Claire, Dani, Krishna, Daniel, Amelia, Daniel, Prabel, Davis, Michelle, Day, Nicola, Doherty, Mandy, Douglas, Catherine, Dunne, Karen, Edwards, Collette, Eglinton, Charlotte, Elmarimi, Abduelbaset, Elmarimi, Hedley, England, Timothy, Epstein, Daniel, Epstein, Renuka, Esisi, Bernard, Evans, Rachel, Farren, Pamela, Fitzell, Pauline, Fletcher, Glyn, Gallifent, Rachel, Gascoyne, Rachel, Giallombardo, Elio, Gregary, Bindu, Gunathilagan, Gunaratam, Guyler, Paul, Hairsine, Brigid, Haley, Michael, Hardwick, Anne, Hargroves, David, Harrington, Frances, Hedstrom, Amanda, Holmes, Clare, Hussein, Senussi, Ingram, Tanya, Ispoglou, Sissi, Iveson, Liz, Johnson, Venetia, Justin, Frances, Kausar, Shahid, Kee, Karen, Keeling, Michael, Khan, Shagufta, Kieliszkowska, Agnieszka, Kingwell, Hayley, Krishnamurthy, Vinodh, Kullane, Sagal, Kumar, Balakrishna, Leach, Simon, Leason, Sana, Lopez, Paula, Luder, Robert, Madigan, Barbara, Maguire, Stuart, Maguire, Holly, Mahawish, Karim, Makawa, Linetty, Mamun, Maam, Manawadu, Dulka, Mangion, David, Manoj, Aravindakshan, Mansoor, Syed, Marsden, Tracy, Marsh, Rachel, Mashate, Sheila, McCormick, Michael, McGolick, Clare, McKee, Madeleine, Mckenzie, Emma, Meenakishundaram, Sanjeevikumar, Mellor, Zoe, Misra, Amulya, Mistri, Amit, Nor, Azlisham Mohd, Mpelembue, Mushiya, Murphy, Peter, Nallasivam, Arumug, Needle, Ann, Nguyen, Vinh, O'Connell, Janice, O’Mahony, Paul, Okwera, James, Orefo, Chukwuka, Owusu-Agyei, Peter, Parry, Anthea, Parry-Jones, Adrian, Pasco, Kath, Patterson, Chris, Peixoto, Cassilda, Perez, Jane, Persad, Nicola, Porteous, Mia, Power, Michael, Price, Christopher, Proschel, Harald, Punekar, Shuja, Putterill, Janet, Randall, Marc, Redjep, Ozlem, Rehman, Habib, Richards, Emma, Riddell, Victoria, Roffe, Christine, Rogers, Gill, Rudd, Anthony, Saastamoinen, Kari, Sajid, Mahmud, Sandhu, Banher, Schofield, Christine, Scott, Jon, Sekaran, Lakshmanan, Sharma, Pankaj, Sharma, Jagdish, Sharpe, Simon, Smith, Matthew, Smith, Anew, Sprigg, Nikola, Staals, Julie, Steele, Amy, Storey, Gail, Storey, Kelley, Subramonian, Santhosh, Sword, Jane, Tallon, Grainne, Tan, Garryck, Tate, Margaret, Teke, Jennifer, Temple, Natalie, Thompson, Teresa, Tysoe, Sharon, Vahidassr, Djamil, Kwaak, Anouk van der, Veltkamp, Roland, Walstow, Deborah, Watchurst, Caroline, Watson, Fran, Waugh, Dean, Wilkinson, Peter, Wilson, David, Wilson-Owen, Sarah, Wroath, Belinda, Wynter, Inez, Young, Emma

مصطلحات موضوعية: Cerebrovascular disease

الوصف: Objective Haptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A HP gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the HP CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after ICH. Methods We included patients with neuroimaging-proven ICH, available DNA and 6-month follow-up in an observational cohort study (CROMIS-2). We classified patients into three groups according to the HP CNV: 1–1, 2–1 or 2–2 and also dichotomised HP into HP1-containing genotypes (HP1-1 and HP2-1) and HP2-2 to evaluate the HP1 allele. We measured ICH and PHO volume on CT; PHO was measured by oedema extension distance. Functional outcome was assessed by modified Rankin score (unfavourable outcome defined as mRS 3–6). Results We included 731 patients (mean age 73.4, 43.5% female). Distribution of HP CNV genotype was: HP1-1 n=132 (18.1%); HP2-1 n=342 (46.8%); and HP2-2 n=257 (35.2%). In the multivariable model mortality comparisons between HP groups, HP2-2 as reference, were as follows: OR HP1-1 0.73, 95% CI 0.34 to 1.56 (p value=0.41) and OR HP2-1 0.5, 95% CI 0.28 to 0.89 (p value=0.02) (overall p value=0.06). We found no evidence of association of HP CNV or rs200999 with functional outcome, ICH volume or PHO volume. Conclusion The HP2-1 genotype might be associated with lower 6-month mortality after ICH; this finding merits further study.

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/91/3/298Test; http://dx.doi.org/10.1136/jnnp-2019-321774Test

الإتاحة: https://doi.org/10.1136/jnnp-2019-321774Test
http://jnnp.bmj.com/cgi/content/short/91/3/298Test

المؤلفون: Wilson, Duncan, Ambler, Gareth, Shakeshaft, Clare, Brown, Martin M, Charidimou, Andreas, Al-Shahi Salman, Rustam, Lip, Gregory Y H, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark J, Yousry, Tarek A, Harkness, Kirsty, Flossmann, Enrico, Smyth, Nigel, Shaw, Louise J, Warburton, Elizabeth, Muir, Keith W, Jäger, Hans Rolf, Werring, David J, Aeron-Thomas, John, Aghoram, Prasanna, Amis, Elaine, Anderton, Peter, Andole, Sreeman, Anwar, Ijaz, Bamford, John, Banaras, Azra, Barry, Aian, Bellfied, Ruth, Benford, Aienne, Bhalla, Ajay, Bhargava, Maneesh, Bhaskaran, Biju, Bhupathiraju, Neelima, Birns, Jonathan, Blight, Aian, Bowring, Angie, Brown, Ellen, Bruce, David, Buck, Amanda, Bunworth, Kerry, Burger, Ilse, Burgess, Laura, Burn, Mathew, Burssens, Evelyn, Burton, Mauian, Butler, Nicola, Button, Denise, Carpenter, Michael

المصدر: The Lancet Neurology ; volume 17, issue 6, page 539-547 ; ISSN 1474-4422

الإتاحة: https://doi.org/10.1016/s1474-4422Test(18)30145-5
https://api.elsevier.com/content/article/PII:S1474442218301455?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1474442218301455?httpAccept=text/plainTest

المؤلفون: Wilson, Duncan, Ambler, Gareth, Shakeshaft, Clare, Brown, Martin M, Charidimou, Andreas, Al-Shahi Salman, Rustam, Lip, Gregory Y H, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark J, Yousry, Tarek A, Harkness, Kirsty, Flossmann, Enrico, Smyth, Nigel, Shaw, Louise J, Warburton, Elizabeth, Muir, Keith W, Jäger, Hans Rolf, Werring, David J, Aeron-Thomas, John, Aghoram, Prasanna, Amis, Elaine, Anderton, Peter, Andole, Sreeman, Anwar, Ijaz, Bamford, John, Banaras, Azra, Barry, Aian, Bellfied, Ruth, Benford, Aienne, Bhalla, Ajay, Bhargava, Maneesh, Bhaskaran, Biju, Bhupathiraju, Neelima, Birns, Jonathan, Blight, Aian, Bowring, Angie, Brown, Ellen, Bruce, David, Buck, Amanda, Bunworth, Kerry, Burger, Ilse, Burgess, Laura, Burn, Mathew, Burssens, Evelyn, Burton, Mauian, Butler, Nicola, Button, Denise, Carpenter, Michael, Chadha, Dinesh, Chatterjee, Kausik, Choy, Lillian, Cohen, David, Connell, Lynne, Cooper, Martin, Corrigan, John, Cotterill, Donna, Courtauld, Gillian, Crawford, Susan, Cullen, Claire, Dani, Krishna, Daniel, Amelia, Datta, Prabel, Davis, Michelle, Day, Nicola, Doherty, Mandy, Douglas, Catherine, Dunne, Karen, Edwards, Collette, Eglinton, Charlotte, Elmarimi, Abduelbaset, Emsley, Hedley, England, Timothy, Epstein, Daniel, Erande, Renuka, Esisi, Bernard, Evans, Rachel, Farren, Pamela, Fitzell, Pauline, Fletcher, Glyn, Gallifent, Rachel, Gascoyne, Rachel, Giallombardo, Elio, Gregary, Bindu, Gunathilagan, Gunaratam, Guyler, Paul, Hairsine, Brigid, Haley, Michael, Hardwick, Anne, Hargroves, David, Harrington, Frances, Hedstrom, Amanda, Holmes, Clare, Hussein, Senussi, Ingram, Tanya, Ispoglou, Sissi, Iveson, Liz, Johnson, Venetia, Justin, Frances, Kausar, Shahid, Kee, Karen, Keeling, Michael, Khan, Shagufta, Kieliszkowska, Agnieszka, Kingwell, Hayley, Krishnamurthy, Vinodh, Kullane, Sagal, Kumar, Balakrishna, Leach, Simon, Leason, Sana, Lopez, Paula, Luder, Robert, Madigan, Barbara, Maguire, Stuart, Maguire, Holly, Mahawish, Karim, Makawa, Linetty, Mamun, Maam, Manawadu, Dulka, Mangion, David, Manoj, Aravindakshan, Mansoor, Syed, Marsden, Tracy, Marsh, Rachel, Mashate, Sheila, McCormick, Michael, McGolick, Clare, McKee, Madeleine, Mckenzie, Emma, Meenakishundaram, Sanjeevikumar, Mellor, Zoe, Misra, Amulya, Mistri, Amit, Mohd Nor, Azlisham, Mpelembue, Mushiya, Murphy, Peter, Nallasivam, Arumug, Needle, Ann, Nguyen, Vinh, O'Connell, Janice, O'Mahony, Paul, Okwera, James, Orefo, Chukwuka, Owusu-Agyei, Peter, Parry, Anthea, Parry-Jones, Adrian, Pasco, Kath, Patterson, Chris, Peixoto, Cassilda, Perez, Jane, Persad, Nicola, Porteous, Mia, Power, Michael, Price, Christopher, Proschel, Harald, Punekar, Shuja, Putterill, Janet, Randall, Marc, Redjep, Ozlem, Rehman, Habib, Richards, Emma, Riddell, Victoria, Roffe, Christine, Rogers, Gill, Rudd, Anthony, Saastamoinen, Kari, Sajid, Mahmud, Sandhu, Banher, Schofield, Christine, Scott, Jon, Sekaran, Lakshmanan, Sharma, Pankaj, Sharma, Jagdish, Sharpe, Simon, Smith, Matthew, Smith, Anew, Sprigg, Nikola, Staals, Julie, Steele, Amy, Storey, Gail, Storey, Kelley, Subramonian, Santhosh, Sword, Jane, Tallon, Grainne, Tan, Garryck, Tate, Margaret, Teke, Jennifer, Temple, Natalie, Thompson, Teresa, Tysoe, Sharon, Vahidassr, Djamil, van der Kwaak, Anouk, Veltkamp, Roland, Walstow, Deborah, Watchurst, Caroline, Watson, Fran, Waugh, Dean, Wilkinson, Peter, Wilson, David, Wilson-Owen, Sarah, Wroath, Belinda, Wynter, Inez, Young, Emma

الوصف: Summary Background: Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that are prone to intracranial bleeding. We aimed to determine whether presence of cerebral microbleeds can identify patients at high risk of symptomatic intracranial haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient ischaemic attack. Methods: Our observational, multicentre, prospective inception cohort study recruited adults aged 18 years or older from 79 hospitals in the UK and one in the Netherlands with atrial fibrillation and recent acute ischaemic stroke or transient ischaemic attack, treated with a vitamin K antagonist or direct oral anticoagulant, and followed up for 24 months using general practitioner and patient postal questionnaires, telephone interviews, hospital visits, and National Health Service digital data on hospital admissions or death. We excluded patients if they could not undergo MRI, had a definite contraindication to anticoagulation, or had previously received therapeutic anticoagulation. The primary outcome was symptomatic intracranial haemorrhage occurring at any time before the final follow-up at 24 months. The log-rank test was used to compare rates of intracranial haemorrhage between those with and without cerebral microbleeds. We developed two prediction models using Cox regression: first, including all predictors associated with intracranial haemorrhage at the 20% level in univariable analysis; and second, including cerebral microbleed presence and HAS-BLED score. We then compared these with the HAS-BLED score alone. This study is registered with ClinicalTrials.gov, number NCT02513316. Findings: Between Aug 4, 2011, and July 31, 2015, we recruited 1490 participants of whom follow-up data were available for 1447 (97%), over a mean period of 850 days (SD 373; 3366 patient-years). The symptomatic intracranial haemorrhage rate in patients with cerebral microbleeds was 9·8 per 1000 patient-years (95% CI 4·0–20·3) compared ...

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956310/pdfTest/; The Lancet. Neurology; Wilson, D., G. Ambler, C. Shakeshaft, M. M. Brown, A. Charidimou, R. Al-Shahi Salman, G. Y. H. Lip, et al. 2018. “Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study.” The Lancet. Neurology 17 (6): 539-547. doi:10.1016/S1474-4422(18)30145-5. http://dx.doi.org/10.1016/S1474-4422Test(18)30145-5.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:37298417Test

الإتاحة: https://doi.org/10.1016/S1474-4422Test(18)30145-5
http://nrs.harvard.edu/urn-3:HUL.InstRepos:37298417Test