دورية أكاديمية
Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
| العنوان: | Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis |
|---|---|
| المؤلفون: | Bigi, María M., Blanco, Federico Carlos, Araújo, Flabio R., Thacker, Tyler C., Zumárraga, Martín José, Cataldi, Ángel Adrián, Soria, Marcelo A., Bigi, Fabiana |
| بيانات النشر: | Wiley Blackwell Publishing, Inc |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | MYCOBACTERIUM BOVIS, MYCOBACTERIUM TUBERCULOSIS, POLYMORPHISM, REGULATOR, https://purl.org/becyt/ford/1.6Test, https://purl.org/becyt/ford/1Test |
| الوصف: | Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis. ; Fil: Bigi, María M. Universidad de Buenos Aires. Facultad de Agronomía; Argentina ; Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Araújo, Flabio R. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil ; Fil: Thacker, Tyler C. United States Department of Agriculture. Agriculture Research Service; Estados Unidos ; Fil: Zumárraga, Martín José. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina ; Fil: Soria, Marcelo A. Universidad de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0385-5600 |
| العلاقة: | http://hdl.handle.net/11336/115328Test; Bigi, María M.; Blanco, Federico Carlos; Araújo, Flabio R.; Thacker, Tyler C.; Zumárraga, Martín José; et al.; Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis; Wiley Blackwell Publishing, Inc; Microbiology And Immunology; 60; 8; 8-2016; 552-560; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1111/1348-0421.12402Test http://hdl.handle.net/11336/115328Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.398101FE |
| قاعدة البيانات: | BASE |
| تدمد: | 03855600 |
|---|