المؤلفون: Isaac Allen, Hend Hassan, Walburga Yvonne Joko-Fru, Catherine Huntley, Lucy Loong, Tameera Rahman, Bethany Torr, Andrew Bacon, Craig Knott, Sophie Jose, Sally Vernon, Margreet Lüchtenborg, Joanna Pethick, Katrina Lavelle, Fiona McRonald, Diana Eccles, Eva J.A Morris, Steven Hardy, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المصدر: The Lancet Regional Health. Europe, Vol 40, Iss , Pp 100903- (2024)

مصطلحات موضوعية: Breast cancer, Second primary cancer, Risk, Incidence, Treatment, Pathology, Public aspects of medicine, RA1-1270

الوصف: Summary: Background: Second primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the largest BC survivor cohort to date, using a novel linkage of National Disease Registration Service datasets. Methods: The cohort included 581,403 female and 3562 male BC survivors diagnosed between 1995 and 2019. We estimated standardized incidence ratios (SIRs) for combined and site-specific SPCs using incidences for England, overall and by age at BC and socioeconomic status. We estimated incidences and Kaplan–Meier cumulative risks stratified by age at BC, and assessed risk variation by socio-demographic, tumour, and treatment characteristics using Cox regression. Findings: Both genders were at elevated contralateral breast (SIR: 2.02 (95% CI: 1.99–2.06) females; 55.4 (35.5–82.4) males) and non-breast (1.10 (1.09–1.11) females, 1.10 (1.00–1.20) males) SPC risks. Non-breast SPC risks were higher for females younger at BC diagnosis (SIR: 1.34 (1.31–1.38)

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666776224000693Test; https://doaj.org/toc/2666-7762Test

الوصول الحر: https://doaj.org/article/2bb76f742aa448a4bbc11bef987cfb06Test

المؤلفون: Allen, Isaac, Hassan, Hend, Joko-Fru, Walburga Yvonne, Huntley, Catherine, Loong, Lucy, Rahman, Tameera, Torr, Bethany, Bacon, Andrew, Knott, Craig, Jose, Sophie, Vernon, Sally, Lüchtenborg, Margreet, Pethick, Joanna, Lavelle, Katrina, McRonald, Fiona, Eccles, Diana, Morris, Eva JA, Hardy, Steven, Turnbull, Clare, Tischkowitz, Marc, Pharoah, Paul, Antoniou, Antonis C

مصطلحات موضوعية: Breast cancer, Deprivation, Epidemiology, Incidence, Pathology, Risk, Second primary cancer, Treatment

الوصف: BACKGROUND: Second primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the largest BC survivor cohort to date, using a novel linkage of National Disease Registration Service datasets. METHODS: The cohort included 581,403 female and 3562 male BC survivors diagnosed between 1995 and 2019. We estimated standardized incidence ratios (SIRs) for combined and site-specific SPCs using incidences for England, overall and by age at BC and socioeconomic status. We estimated incidences and Kaplan-Meier cumulative risks stratified by age at BC, and assessed risk variation by socio-demographic, tumour, and treatment characteristics using Cox regression. FINDINGS: Both genders were at elevated contralateral breast (SIR: 2.02 (95% CI: 1.99-2.06) females; 55.4 (35.5-82.4) males) and non-breast (1.10 (1.09-1.11) females, 1.10 (1.00-1.20) males) SPC risks. Non-breast SPC risks were ...

الإتاحة: https://doi.org/10.17863/cam.107482Test
https://www.repository.cam.ac.uk/handle/1810/366625Test

المؤلفون: Maja Šutić, Jurica Baranašić, Lana Kovač Bilić, Mario Bilić, Antonija Jakovčević, Luka Brčić, Sven Seiwerth, Marko Jakopović, Miroslav Samaržija, Ulrich Zechner, Jelena Knežević

المصدر: Diagnostic Pathology, Vol 16, Iss 1, Pp 1-5 (2021)

مصطلحات موضوعية: HNSCC, Second primary tumor, Lung, Diagnostic biomarker, Methylation, CpG, Pathology, RB1-214

الوصف: Abstract Background Patients with head and neck squamous cell carcinoma (HNSCC) can develop lung squamous cell carcinoma (LuSCC), which could be the second primary tumor or HNSCC metastasis. Morphologically it is difficult to distinguish metastatic HNSCC from a second primary tumor which presents a significant diagnostic challenge. Differentiation of those two malignancies is important because the recommended treatments for metastatic HNSCC and primary LuSCC differ significantly. We investigated if the quantification of the promotor methylation status in HNSCC and LuSCC differs. Methods Primary HNSCC (N = 36) and LuSCC (N = 17) were included in this study. Methylation status in the ASC/TMS1/PYCARD (apoptosis-associated speck-like protein containing a caspase recruitment domain; 8 CpG sites) and MyD88 (Myeloid differentiation primary response protein 88; 10 CpG sites) promoters was analyzed. Bisulfite converted DNA, isolated from tumor tissue was quantified using pyrosequencing. Results of pyrosequencing analysis were expressed as a percentage for each tested CpG site. Receiver-operating characteristic (ROC) curve analysis was used for the evaluation of the diagnostic properties of selected biomarkers. Results CpG sites located in the promoters of ASC/TMS1/PYCARD_CpG8 (− 65 upstream) and MyD88_CpG4 (− 278 upstream) are significantly hypermethylated in the HNSCC when compared with LuSCC (p ≤ 0.0001). By performing ROC curve analysis we showed that corresponding areas under the curve (AUC) were 85–95%, indicating that selected CpG sites are useful for a distinction between primary LuSCC and primary HNSCC. Conclusions Results of the present study indicate that there is a significant difference in the methylation status of tested genes between primary HNSCC and LuSCC. However, to prove this approach as a useful tool for distinguishing second primary LuSCC from HNSCC metastasis, it would be necessary to include a larger number of samples, and most importantly, metastatic samples.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1746-1596Test

الوصول الحر: https://doaj.org/article/4fd68a3652fb4856a1e276c4d5560e58Test

المؤلفون: Wei GUO, Jing⁃hui LIU, Pei⁃gang JI, Miao LOU, Yu⁃long ZHAI, Guo⁃dong GAO, Yan QU, Liang WANG

المصدر: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 12, Pp 958-963 (2019)

مصطلحات موضوعية: glioma, sarcoma, neoplasms, second primary, pathology, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective A case of secondary gliosarcoma transformed from lower grade glioma was analyzed. The clinicopathological features, molecular pathological features and prognosis of secondary gliosarcoma were discussed with relevant literatures. Methods and Results A 42⁃year⁃old female patient was admitted to our hospital. CT showed occupying lesion in left frontal lobe. The first surgery was performed and the initial pathological diagnosis was oligodendroglioma (WHO Ⅱ grade). Nineteen months after the first surgery, the tumor recurred, and the second surgery and chemotherapy were performed. The post⁃operative pathological diagnosis was glioblastoma (WHOⅣgrade). Twenty⁃two months after the second surgery, the tumor recurred again. Then the third surgery was performed and the pathological diagnosis was gliosarcoma (WHOⅣgrade). Radiotherapy and chemotherapy were given after operation. The patient died 14 months after the third surgery. Conclusions According to the 2016 WHO classification, gliosarcoma, classified as a subtype of glioblastoma, was a WHO grade Ⅳ tumor. As of now, the treatment paradigms for gliosarcoma were similar to that of gliosarcoma, including maximal safe resection, post ⁃ operative radiotherapy and concurrent and adjuvant chemotherapy. IDH1 mutation and MGMT promoter methylation had certain predictive value for the prognosis. DOI：10.3969/j.issn.1672⁃6731.2019.12.009

وصف الملف: electronic resource

العلاقة: http://www.cjcnn.org/index.php/cjcnn/article/view/2065Test; https://doaj.org/toc/1672-6731Test

الوصول الحر: https://doaj.org/article/911da8f25c2c450cbd48b6d8275201fbTest

المؤلفون: Cooperberg, MR, Fiedler, PN

المصدر: Annals of diagnostic pathology. 5(3)

مصطلحات موضوعية: Colon, Ileum, Humans, Adenocarcinoma, Colonic Neoplasms, Neoplasms, Second Primary, Antigens, CD30, Anastomosis, Surgical, Aged, Aged, 80 and over, Male, Lymphoma, Large-Cell, Anaplastic, Ki-1 Antigen, Neoplasms, Second Primary, Antigens, CD30, Anastomosis, Surgical, and over, Lymphoma, Large-Cell, Anaplastic, Pathology, Physiology, Clinical Sciences

الوصف: Systemic anaplastic large-cell lymphoma is an uncommon type of non-Hodgkin lymphoma characterized by strong expression of the Ki-1 (CD30) antigen. Gastrointestinal involvement typically is less common than in other types of non-Hodgkin's lymphoma. We report a case of CD30-positive anaplastic large-cell lymphoma occurring at the site of colonic anastomosis in an elderly patient who had been treated for colonic adenocarcinoma by right hemicolectomy 10 years previously. The lymphoma was a 2-cm mass composed of large, atypical cells infiltrating the mucosa, submucosa, and muscularis propria. Immunoperoxidase stain was strongly positive for Ki-1, and negative for LeuM1, L26, UCHL1, EMA, and cytokeratin. There have been numerous reports of unusual extranodal presentations of systemic anaplastic large-cell lymphoma; the only previously reported case involving the colon, however, occurred in the context of ulcerative colitis. Anastomotic recurrence is a relatively common complication of surgical therapy for adenocarcinoma, but the recurrent tumors are invariably adenocarcinomas. We are aware of no cases of lymphoma of any type occurring at the site of anastomosis after resection for adenocarcinoma.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/080769gsTest

المؤلفون: Antoniv V.F., Popadyuk V.I., Chernolev A.I.

المصدر: Vestnik Oto-Rino-Laringologii

مصطلحات موضوعية: adjuvant radiotherapy, adverse effects, aged, auditory canal, case report, Ear Neoplasms, ear surgery, human, male, multimodality cancer therapy, Neoplasms, Second Primary, pathology, pathophysiology, procedures, reoperation, treatment failure, Combined Modality Therapy, Ear Canal, Humans, Otologic Surgical Procedures, Radiotherapy, Adjuvant

الوصف: [No abstract available]

العلاقة: https://doi.org/10.17116/otorino201681330-32Test; https://openrepository.ru/article?id=254579Test

الإتاحة: https://doi.org/10.17116/otorino201681330-32Test
https://openrepository.ru/article?id=254579Test

المؤلفون: Lauren Hasty, Dominique Cazals-Hatem, Gaëlle Pierron, Sophie Bockel, Emmanuèle Lechapt, Arnault Tauziède-Espariat, Nicolas Weinbreck, Delphine Guillemot, Fabrice Chrétien, Pascale Varlet, Alexandre Roux, Thierry Faillot, Joseph Benzakoun, Philipp Sievers

المصدر: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-6 (2021)
Acta Neuropathologica Communications

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Neurology, Oncogene Proteins, Fusion, Central nervous system, Case Report, Malignancy, Pathology and Forensic Medicine, Cyclic AMP Response Element Modulator, Cellular and Molecular Neuroscience, CREM, Fatal Outcome, SMARCA2, Meningeal Neoplasms, medicine, Humans, Epigenetics, RC346-429, Intracranial mesenchymal tumor, Brain Neoplasms, Angiomatoid fibrous histiocytoma, business.industry, Mesenchymal stem cell, Neoplasms, Second Primary, medicine.disease, medicine.anatomical_structure, Neurology (clinical), Clear-cell sarcoma, Neurology. Diseases of the nervous system, Meningioma, business, Clear cell, Transcription Factors

الوصف: A novel histomolecular tumor of the central nervous system, the “intracranial mesenchymal tumor (IMT), FET-CREB fusion-positive” has recently been identified in the literature and will be added to the 2021 World Health Organization Classification of Tumors of the Central Nervous System. However, our latest study using DNA-methylation analyses has revealed that intracranial FET-CREB fused tumors do not represent a single molecular tumor entity. Among them, the main subgroup presented classical features of angiomatoid fibrous histiocytoma, having ultrastructural features of arachnoidal cells, for. Another tumor type with clear cell component and histopathological signs of aggressivity clustered in close vicinity with clear cell sarcoma of soft tissue. Herein, we report one case of IMT with a novel SMARCA2-CREM fusion which has until now never been described in soft tissue or the central nervous system. We compare its clinical, histopathological, immunophenotypic, genetic and epigenetic features with those previously described in IMT, FET-CREB fusion-positive. Interestingly, the current case did not cluster with IMT, FET-CREB fusion-positive but rather presented histopathological (clear cell morphology with signs of malignancy), clinical (with a dismal course with several recurrences, metastases and finally the patient’s death), genetic (fusion implicating the CREM gene), and epigenetic (DNA-methylation profiling) similarities with our previously reported clear cell sarcoma-like tumor of the central nervous system. Our results added data suggesting that different clinical and histomolecular tumor subtypes or grades seem to be included within the terminology “IMT, FET-CREB fusion-positive”, and that further series of cases are needed to better characterize them.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d85d0728306900317d5a68f4c861432Test
https://doaj.org/article/b765016684ef49e5bef9701664729b05Test

المؤلفون: Qimin Zhan, Zhimin Feng, Liyan Xue, Xuanlin Huang, Peina Du, Yongmei Song, Ning Lu, Peide Huang, Xuemin Xue, Linxiu Liu, Xinyi Fan, Weihua Li, Wei Zhou, Jia Guo, Zitong Zhao, Hua Lin, Lin Li

المصدر: Theranostics

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, clonal relationship, Lung Neoplasms, Esophageal Neoplasms, Cell, Medicine (miscellaneous), medicine.disease_cause, Esophageal squamous cell carcinoma, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Esophagus, Exome Sequencing, medicine, Biomarkers, Tumor, Humans, whole-exome sequencing, Pneumonectomy, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Pathological, Lymph node, Lung, Exome sequencing, second primary tumor, Aged, Aged, 80 and over, business.industry, lung metastasis, Neoplasms, Second Primary, Middle Aged, esophageal squamous cell carcinoma, Esophagectomy, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Carcinogenesis, business, Research Paper

الوصف: Esophageal squamous cell carcinoma (ESCC) patients with a synchronous or metachronous lung tumor can be diagnosed with lung metastasis (LM) or a second primary tumor (SPT), but the accurate discrimination between LM and SPT remains a clinical dilemma. This study aimed to investigate the feasibility of using the whole-exome sequencing (WES) technique to distinguish SPT from LM. Methods: We performed WES on 40 tumors from 14 patients, including 12 patients with double squamous cell carcinomas (SCCs) of the esophagus and lung (lymph node metastases were sequenced as internal controls) diagnosed as LM according to pathological information and 2 patients with paired primary ESCC and non-lung metastases examined as external controls. Results: Shared genomic profiles between esophageal (T) and lung (D) tumors were observed in 7 patients, suggesting their clonal relatedness, thus indicating that the lung tumors of these patients should be LM. However, distinct genomic profiles between T and D tumors were observed in the other 5 patients, suggesting the possibility of SPTs that were likely formed through independent multifocal oncogenesis. Conclusions: Our data demonstrate the limitations and insufficiency of clinicopathological criteria and that WES could be useful in understanding the clonal relationships of multiple SCCs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a677991d0bf3dbedafa560f363c8bbTest
http://europepmc.org/articles/PMC7482800Test

المؤلفون: Nihal Durmaz, Ömer Kartal, Onur Akın, İrem Ayşe Atasoy, Erman Ataş

المصدر: JCRPE, Vol 13, Iss 2, Pp 225-231 (2021)
Journal of Clinical Research in Pediatric Endocrinology

مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Puberty, Precocious, Case Report, Malignancy, oncocytic variant, Pediatrics, RJ1-570, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine, adrenocortical carcinoma, Adenoma, Oxyphilic, Humans, Adrenocortical carcinoma, Sex organ, Family history, Rhabdomyosarcoma, Chemotherapy, child, business.industry, Adrenalectomy, Virilization, Infant, Neoplasms, Second Primary, tp53, medicine.disease, RC648-665, 030104 developmental biology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, rhabdomyosarcoma, medicine.symptom, business

الوصف: Most cases of malignancies appear to be sporadic, but some syndromes are associated with malignancies with germline variants. Herein, a child with an unusual association of oncocytic variant adrenocortical carcinoma (ACC) and rhabdomyosarcoma (RMS) was presented. An 18-month-old-boy was admitted with virilization of the genital area, penis enlargement and erection, which had begun six months earlier. Serum total testosterone (457 ng/dL; NR

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848d806501f3994e06f6a1996b9740f9Test
https://doaj.org/article/ccc988a812d643d6a0c26e3680433949Test

المؤلفون: Changfei Qin, Lihong Zhang, Jia-Bin Lu, Suxia Lin, Fang Wang, Xiaoxuan Li, Shengbing Zang, Jie-Tian Jin, Qunxi Chen, Xinke Zhang, Taoli Wang

المصدر: Thoracic Cancer
Thoracic Cancer, Vol 11, Iss 8, Pp 2297-2305 (2020)

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, squamous cell carcinoma, Male, Pathology, medicine.medical_specialty, Human papillomavirus, Lung Neoplasms, Papillomavirus E7 Proteins, Uterine Cervical Neoplasms, Alphapapillomavirus, lcsh:RC254-282, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Basal cell, In patient, Neoplasm Metastasis, Cervix, second primary tumor, Aged, Tissue microarray, Lung, RNAscope assay, business.industry, lung metastasis, General Medicine, Second primary cancer, Original Articles, respiratory system, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Immunohistochemistry, Original Article, Female, business

الوصف: Background In patients with squamous cell carcinoma of the cervix (SCCC), a squamous cell carcinoma (SqCC) in the lung represents either a second primary tumor or metastasis. This distinction between second primary tumors and lung metastases in patients with SCCC significantly influences patient prognosis and therapy. Here, we aimed to differentiate second primary tumors from lung metastases in patients with SCCC by exploring the HPV status in SqCCs involving the lung within a large cohort. Methods P16 expression was assessed using immunohistochemistry on tissue microarrays including a total of 415 primary lung SqCCs and 21 lung SqCCs with prior SCCC. Following this, we performed HPV DNA typing and the sensitive RNAscope in situ method to screen all the cases for HPV E6/E7 expression, which is a more reliable indicator of transcriptively active HPV in tumor cells. Results The p16 positive expression rate was 13.7% (57/415) in primary lung SqCCs, but HPV DNA was not detected in any of the 57 primary lung SqCC cases that positively expressed p16. In contrast, HPV DNA was detected in all cases (21/21) with prior SCCC. Consistently, all 21 lung SqCCs with prior SCCC (21/21) showed extensive HPV16 E6/E7 expression. In striking contrast, none of the primary lung SqCCs (0/415) had a detectable RNAscope signal. Conclusions HPV does not seem to play a role in the development of primary lung SqCCs. HPV detection may be helpful in distinguishing second primary tumors from lung metastases in patients with SCCC.
HPV does not seem to play a role in the development of primary lung SqCCs. HPV detection may be helpful in distinguishing second primary tumors from lung metastases in patients with SCCC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0019baf85c0997f59c42d748c14c00bTest
http://europepmc.org/articles/PMC7396378Test