دورية أكاديمية
An update on the role of leptin in the immuno-metabolism of cartilage
| العنوان: | An update on the role of leptin in the immuno-metabolism of cartilage |
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| المؤلفون: | Cordero-Barreal, Alfonso, González-Rodríguez, María, Ruiz-Fernández, Clara, Eldjoudi, Djedjiga Ait, AbdElHafez, Yousof Ramadan Farrag, Lago, Francisca, Conde, Javier, Gómez, Rodolfo, González-Gay Mantecón, Miguel Ángel, Mobasheri, Ali, Pino, Jesus, Gualillo, Oreste |
| المساهمون: | Universidad de Cantabria |
| المصدر: | Int J Mol Sci . 2021 Feb 27;22(5):2411 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Universidad de Cantabria: UCrea |
| مصطلحات موضوعية: | Leptin, Articular cartilage, Chondrocyte, LEPR (ObR), Osteoarthritis (OA), Rheumatoid arthritis (RA) |
| الوصف: | Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic effects. In this review, we summarize the actual information about the impact of this hormone on cartilage metabolism and pathology. Leptin signalling depends on the interaction with leptin receptor LEPR, being the long isoform of the receptor (LEPRb) the one with more efficient intracellular signalling. Chondrocytes express the long isoform of the leptin receptor and in these cells, leptin signalling, alone or in combination with other molecules, induces the expression of pro-inflammatory molecules and cartilage degenerative enzymes. Leptin has been shown to increase the proliferation and activation of immune cells, increasing the severity of immune degenerative cartilage diseases. Leptin expression in serum and synovial fluid are related to degenerative diseases such as osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Inhibition of leptin signalling showed to have protective effects in these diseases showing the key role of leptin in cartilage degeneration. ; Acknowledgments: This work was supported by Xunta de Galicia (Servizo Galego de Saude, SERGAS), through a research-staff contract (ISCIII/SERGAS) to OG and FL, which are Staff Personnel (I3SNS stable Researcher), by Instituto de Salud Carlos III (ISCIII) and by FEDER through a predoctoral research scholar to CR-F (Exp.18/00188), and “Miguel Servet” Researcher contract to RG and JC. MG is a recipient of pre-doctoral contract funded by Xunta de Galicia (IN606A-2020/010). AC is a recipient of a pre-doctoral contract funded by Secretaría de Estado de Universidades, Investigación, Desarrollo e Innovación, Ministerio de Universidades (FPU2018-04165). OG is member of RETICS Programme, [RD16/0012/0014] (RIER: Red de Investigación en Inflamación y Enfermedades Reumáticas) via ISCIII and FEDER. FL is a member of CIBERCV (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares). ISCIII and FEDER also support OG and JP ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| العلاقة: | https://doi.org/10.3390Test/ ijms22052411; http://hdl.handle.net/10902/24454Test |
| DOI: | 10.3390/ijms22052411 |
| الإتاحة: | https://doi.org/10.3390/ijms22052411Test http://hdl.handle.net/10902/24454Test |
| حقوق: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license. ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.9E8D88D6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 14220067 |
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| DOI: | 10.3390/ijms22052411 |