نتائج البحث - "Romana T. Netea-Maier"

1

دورية أكاديمية

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

المصدر: Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)

مصطلحات موضوعية: Metabolomics, Genomics, Immune phenotypes, Integrative analysis, Biology (General), QH301-705.5, Genetics, QH426-470

الوصف: Abstract Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn’s disease, suggesting it is a potential therapeutic target. Conclusion This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1474-760XTest

الوصول الحر: https://doaj.org/article/c356b25dd4854dcbb5ff8d2fda446129Test

View record in DOAJ

النص الكامل

2

دورية أكاديمية

Additional file 25 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

المؤلفون: Xiaojing Chu (1594045), Martin Jaeger (3465044), Joep Beumer (11085603), Olivier B. Bakker (8677464), Raul Aguirre-Gamboa (458865), Marije Oosting (202291), Sanne P. Smeekens (11085606), Simone Moorlag (11085609), Vera P. Mourits (11085612), Valerie A. C. M. Koeken (11085615), Charlotte de Bree (11085618), Trees Jansen (11085621), Ian T. Mathews (11085624), Khoi Dao (9900319), Mahan Najhawan (11085627), Jeramie D. Watrous (4029923), Irma Joosten (27492), Sonia Sharma (3755452), Hans J. P. M. Koenen (8071466), Sebo Withoff (102402), Iris H. Jonkers (11085630), Romana T. Netea-Maier (11085633), Ramnik J. Xavier (153776), Lude Franke (102406), Cheng-Jian Xu (3620711), Leo A. B. Joosten (7547705), Serena Sanna (145737), Mohit Jain (38715), Vinod Kumar (48743), Hans Clevers (211819), Cisca Wijmenga (32954), Mihai G. Netea (7241447), Yang Li (11085636)

مصطلحات موضوعية: Genetics, Metabolomics, Genomics, Immune phenotypes, Integrative analysis

الوصف: Additional file 25. Review history.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_25_of_Integration_of_metabolomics_genomics_and_immune_phenotypes_reveals_the_causal_roles_of_metabolites_in_disease/14921227Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14921227.v1Test

View record in BASE

3

دورية أكاديمية

Additional file 5 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

المؤلفون: Xiaojing Chu (1594045), Martin Jaeger (3465044), Joep Beumer (11085603), Olivier B. Bakker (8677464), Raul Aguirre-Gamboa (458865), Marije Oosting (202291), Sanne P. Smeekens (11085606), Simone Moorlag (11085609), Vera P. Mourits (11085612), Valerie A. C. M. Koeken (11085615), Charlotte de Bree (11085618), Trees Jansen (11085621), Ian T. Mathews (11085624), Khoi Dao (9900319), Mahan Najhawan (11085627), Jeramie D. Watrous (4029923), Irma Joosten (27492), Sonia Sharma (3755452), Hans J. P. M. Koenen (8071466), Sebo Withoff (102402), Iris H. Jonkers (11085630), Romana T. Netea-Maier (11085633), Ramnik J. Xavier (153776), Lude Franke (102406), Cheng-Jian Xu (3620711), Leo A. B. Joosten (7547705), Serena Sanna (145737), Mohit Jain (38715), Vinod Kumar (48743), Hans Clevers (211819), Cisca Wijmenga (32954), Mihai G. Netea (7241447), Yang Li (11085636)

مصطلحات موضوعية: Genetics, Metabolomics, Genomics, Immune phenotypes, Integrative analysis

الوصف: Additional file 5. Fig. S1-8

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_5_of_Integration_of_metabolomics_genomics_and_immune_phenotypes_reveals_the_causal_roles_of_metabolites_in_disease/14921239Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14921239.v1Test

View record in BASE

4

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Molecular Neuroscience and Ageing Research (MOLAR), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Stem Cell Aging Leukemia and Lymphoma (SALL), CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover., TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany., BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.

المصدر: Genome Biology, 22(1). BioMed Central
Genome Biology, 22, 1
Genome Biology, 22
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Genome Biology, 22(1):198. BMC
Genome biology
United States
International
England

مصطلحات موضوعية: Male, 0301 basic medicine, Metabolite, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Immune phenotypes, Disease, VARIANTS, SUSCEPTIBILITY, QH426-470, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, RARE, WIDE ASSOCIATION, Biology (General), POLYUNSATURATED FATTY-ACIDS, Genetics, Alanine, Arachidonic Acid, Genomics, Middle Aged, CROHNS-DISEASE, Healthy Volunteers, Phenotype, MENDELIAN RANDOMIZATION, GENETIC-FACTORS, Female, Metabolic Networks and Pathways, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], EXPRESSION, Adult, Adolescent, QH301-705.5, Quantitative Trait Loci, Glutamic Acid, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Biology, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Metabolomics, Immune system, Metabolome, Humans, COMMON, Aged, Research, Integrative analysis, Immunity, Innate, Human genetics, Metabolic pathway, 030104 developmental biology, chemistry, 030217 neurology & neurosurgery, Genome-Wide Association Study

الوصف: Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn’s disease, suggesting it is a potential therapeutic target. Conclusion This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca2418c59e637207e61226dad14da6aTest
https://doi.org/10.1186/s13059-021-02413-zTest