دورية أكاديمية
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
| العنوان: | Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease |
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| المؤلفون: | Ho Cheol Kim, Mahroo Mofarrahi, Sabah NA Hussain |
| المصدر: | International Journal of COPD, Vol 2008, Iss Issue 4, Pp 637-658 (2009) |
| بيانات النشر: | Dove Medical Press, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Diseases of the respiratory system, RC705-779 |
| الوصف: | Ho Cheol Kim1, Mahroo Mofarrahi2, Sabah NA Hussain21Department of Internal Medicine, College of Medicine, Gyeongsang National University, Gyeongsang University Hospital, Jinju, Korea; 2Critical Care and Respiratory Divisions, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, CanadaAbstract: Chronic obstructive pulmonary disease (COPD) is a debilitating disease characterized by inflammation-induced airflow limitation and parenchymal destruction. In addition to pulmonary manifestations, patients with COPD develop systemic problems, including skeletal muscle and other organ-specific dysfunctions, nutritional abnormalities, weight loss, and adverse psychological responses. Patients with COPD often complain of dyspnea on exertion, reduced exercise capacity, and develop a progressive decline in lung function with increasing age. These symptoms have been attributed to increases in the work of breathing and in impairments in gas exchange that result from airflow limitation and dynamic hyperinflation. However, there is mounting evidence to suggest that skeletal muscle dysfunction, independent of lung function, contributes significantly to reduced exercise capacity and poor quality of life in these patients. Limb and ventilatory skeletal muscle dysfunction in COPD patients has been attributed to a myriad of factors, including the presence of low grade systemic inflammatory processes, nutritional depletion, corticosteroid medications, chronic inactivity, age, hypoxemia, smoking, oxidative and nitrosative stresses, protein degradation and changes in vascular density. This review briefly summarizes the contribution of these factors to overall skeletal muscle dysfunction in patients with COPD, with particular attention paid to the latest advances in the field.Keywords: skeletal muscles, chronic obstructive pulmonary disease, diaphragm, quadriceps, fatigue, disuse, atrophy, smoking, exercise |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1176-9106 1178-2005 |
| العلاقة: | http://www.dovepress.com/skeletal-muscle-dysfunction-in-patients-with-chronic-obstructive-pulmo-a2819Test; https://doaj.org/toc/1176-9106Test; https://doaj.org/toc/1178-2005Test |
| الوصول الحر: | https://doaj.org/article/b69a70016e27426db49d8ed8d2361c98Test |
| رقم الانضمام: | edsdoj.b69a70016e27426db49d8ed8d2361c98 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11769106 11782005 |
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