التفاصيل البيبلوغرافية
| العنوان: |
HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa |
| المؤلفون: |
Maponga, Tongai Gibson, Andersson, Monique I., van Rensburg, Christoffel J., Arends, Joop E., Taljaard, Jantjie, Preiser, Wolfgang, Glashoff, Richard H. |
| المساهمون: |
Poli VCK, MS Interne Geneeskunde, Infection & Immunity |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Anti-retroviral treatment, Cytokines, Hepatitis B infection, HIV, Microbial translocation products, Transient elastography, Viraemia, Infectious Diseases |
| الوصف: |
Background: Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most important intersection of high endemicity of both chronic hepatitis B virus (HBV) infection and HIV infection. Methods: We recruited 46 HBV/HIV-co-infected; 47 HBV-monoinfected; 39 HIV-monoinfected; and 37 HBV/HIV-uninfected patients from Tygerberg Hospital, Cape Town, South Africa. All HIV-infected patients were on antiretroviral therapy for ≥3 months. Liver stiffness measurements were assessed using the Fibroscan (Fibroscan 402, Echosens). Cell-based immunomarkers were measured by flow cytometry. Soluble serum/plasma immunomarkers were measured by Luminex technology and enzyme immunoassays. HIV (COBAS/Ampliprep TaqMan HIV-1) and HBV viral loads (in-house assay) were also performed. Results: HBV/HIV co-infected patients showed significantly higher levels of immune activation 8+/HLA-DR+/CD38+ (median 30%, interquartile range: 17-53) and 8+/PD-1 (median 22%, interquartile range: 15-33), p ≤ 0.01 compared to all other study groups. Despite this, the HBV-mono-infected group had the highest proportion of patients with advanced liver fibrosis (≥13 kPa) as measured by Fibroscan (18%). HBV mono-infected patients showed highest expression of most cytokines including IL-17 and basic fibroblastic growth factor. There was significant positive correlation between detectable HIV and HBV viral replication and liver fibrosis but not immune activation or gut translocation. Discussion: Highly-active antiretroviral therapy, including tenofovir, is effective against both HIV and HBV. Earlier therapy in the co-infected patients may therefore have controlled viral replication leading to better fibrosis scores when compared to HBV mono-infection in this study. On-going HBV and HIV viraemia, rather than microbial translocation or immune activation, appear to be the drivers of liver fibrosis. Moderate to advanced liver ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
image/pdf |
| اللغة: |
English |
| تدمد: |
1471-2334 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/374238Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/374238Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.3F7C1802 |
| قاعدة البيانات: |
BASE |
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