Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes
| العنوان: | Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes |
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| المؤلفون: | Stacey M. Anderson, Shelly K. McCrady-Spitzer, Angelo Avogaro, Boris Kovatchev, Patrick Keith-Hynes, Yogish C. Kudva, Yenny Leal, Sue A. Brown, Nihat Baysal, Carol J. Levy, Simone Del Favero, Ananda Basu, Roberto Visentin, Silvia Galasso, Federico Boscari, David W. Lam, Claudio Cobelli, Laura L. Kollar, Camilla Levister, Daniela Bruttomesso, Ling Hinshaw, Marc D. Breton, Vikash Dadlani |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 102:3674-3682 |
| بيانات النشر: | The Endocrine Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Blood Glucose, Male, Adult, Blood Glucose Self-Monitoring, Cross-Over Studies, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Insulin, Middle Aged, Young Adult, Circadian Rhythm, Insulin Infusion Systems, Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry (medical), endocrine system diseases, law.invention, 0302 clinical medicine, Randomized controlled trial, immune system diseases, law, Medicine, 030212 general & internal medicine, humanities, Diabetes and Metabolism, Type 1, Insulin pump, medicine.medical_specialty, 030209 endocrinology & metabolism, Context (language use), 03 medical and health sciences, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Clinical Research Articles, Glycemic, Glycated Hemoglobin, Type 1 diabetes, urogenital system, business.industry, nutritional and metabolic diseases, medicine.disease, Crossover study, business |
| الوصف: | Context Closed-loop control (CLC) for the management of type 1 diabetes (T1D) is a novel method for optimizing glucose control, and strategies for individualized implementation are being developed. Objective To analyze glycemic control in an overnight CLC system designed to "reset" the patient to near-normal glycemic targets every morning. Design Randomized, crossover, multicenter clinical trial. Participants Forty-four subjects with T1D requiring insulin pump therapy. Intervention Sensor-augmented pump therapy (SAP) at home vs 5 nights of CLC (active from 23:00 to 07:00) in a supervised outpatient setting (research house or hotel), with a substudy of 5 nights of CLC subsequently at home. Main Outcome Measure The percentage of time spent in the target range (70 to 180 mg/dL measured using a continuous glucose monitor). Results Forty subjects (age, 45.5 ± 9.5 years; hemoglobin A1c, 7.4% ± 0.8%) completed the study. The time in the target range (70 to 180 mg/dL) significantly improved in CLC vs SAP over 24 hours (78.3% vs 71.4%; P = 0.003) and overnight (85.7% vs 67.6%; P < 0.001). The time spent in a hypoglycemic range ( |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08baa8adf8ac678aa931f234f13aa70Test https://doi.org/10.1210/jc.2017-00556Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a08baa8adf8ac678aa931f234f13aa70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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