Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma
| العنوان: | Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma |
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| المؤلفون: | Chien-Chin Chen, Dong Che Shiau, Goutham Venkata Naga Davuluri, Yu Chi Su, Chia Ling Chen, Cheng Hao Chen, Yee Shin Lin, Chih Peng Chang |
| المصدر: | PLoS ONE, Vol 11, Iss 2, p e0148408 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Galectin 1, Cancer Treatment, lcsh:Medicine, Apoptosis, Biochemistry, Mice, Mitophagy, Medicine and Health Sciences, lcsh:Science, Energy-Producing Organelles, Cultured Tumor Cells, Staining, Multidisciplinary, Cell Death, Pharmaceutics, Chemistry, Liver Diseases, TOR Serine-Threonine Kinases, Liver Neoplasms, Cell Staining, Hep G2 Cells, Mitochondria, Oncology, Cell Processes, Hepatocellular carcinoma, Galectin-1, Cancer Therapy, Biological Cultures, Cellular Structures and Organelles, Research Article, Signal Transduction, medicine.drug, Programmed cell death, Carcinoma, Hepatocellular, Autophagic Cell Death, ATG5, Gastroenterology and Hepatology, Bioenergetics, Research and Analysis Methods, Carcinomas, 03 medical and health sciences, Drug Therapy, Gastrointestinal Tumors, Autophagy, medicine, Chemotherapy, Animals, Humans, neoplasms, Cisplatin, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, Hepatocellular Carcinoma, Cell Cultures, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, 030104 developmental biology, Specimen Preparation and Treatment, Drug Resistance, Neoplasm, Immunology, Cancer cell, Cancer research, Hepatoma Cells, lcsh:Q, Proto-Oncogene Proteins c-akt |
| الوصف: | Hepatocellular carcinoma (HCC) is one of the most common cancers in Taiwan. Although chemotherapy is the primary treatment for HCC patients, drug resistance often leads to clinical failure. Galectin-1 is a beta-galactoside binding lectin which is up-regulated in HCC patients and promotes tumor growth by mediating cancer cell adhesion, migration and proliferation, but its role in chemoresistance of HCC is poorly understood. In this study we found that galectin-1 is able to lead to chemoresistance against cisplatin treatment, and subsequent inhibition has reversed the effect of cell death in HCC cells. Moreover, galectin-1 was found to induce autophagic flux in HCC cells. Inhibition of autophagy by inhibitors or knockdown of Atg5 cancels galectin-1-induced cisplatin resistance in HCC cells. Increase of mitophagy triggered by galectin-1 was found to reduce the mitochondrial potential loss and apoptosis induced by cisplatin treatment. Finally, using an in situ hepatoma mouse model, we clearly demonstrated that inhibition of galectin-1 by thiodigalactoside could significantly augment the anti-HCC effect of cisplatin. Taken together, our findings offer a new insight into the chemoresistance galectin-1 causes against cisplatin treatment, and points to a potential approach to improve the efficacy of cisplatin in the treatment of HCC patients. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73b0b8b70ab5b1dda710e4bf3ddf3a1Test https://doi.org/10.1371/journal.pone.0148408Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b73b0b8b70ab5b1dda710e4bf3ddf3a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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