Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease
| العنوان: | Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease |
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| المؤلفون: | Irmscher, Sarah, Zipfel, Svante L. H., Halder, Luke D., Ivanov, Lia, Gonzalez-Delgado, Andres, Waldeyer, Christoph, Seiffert, Moritz, Brunner, Fabian J., von der Heide, Monika, Löschmann, Ina, Wulf, Sonia, Czamara, Darina, Papac-Milicevic, Nikolina, Strauß, Olaf, Lorkowski, Stefan, Reichenspurner, Hermann, Holers, Michael V., Banda, Nirmal K., Zeller, Tania, Binder, Elisabeth B., Binder, Christoph J., Wiech, Thorsten, Zipfel, Peter F., Skerka, Christine |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Molecular biology, Science, Immunology, Cardiology, Diseases, Pathogenesis, Article, Necrosis, Medical research, Genetics, Complement C3b Inactivator Proteins, Humans, Complement Activation, Aged, Sequence Deletion, Inflammation, Molecular medicine, Gene Expression Profiling, Homozygote, Middle Aged, Atherosclerosis, Lipids, Oxygen, Gene Expression Regulation, Cardiovascular Diseases, embryonic structures, Medicine, Female, Chromosome Deletion |
| الوصف: | Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis, and complement activation, resulting in inflammation and thrombosis. The present study found that homozygous deletion of the CFHR1 gene, which encodes the plasma complement protein factor H-related protein 1 (FHR-1), was protective in two cohorts of patients with ACVD, suggesting that FHR-1 accelerates inflammation and exacerbates the disease. To test this hypothesis, FHR-1 was isolated from human plasma and was found to circulate on extracellular vesicles and to be deposited in atherosclerotic plaques. Surface-bound FHR-1 induced the expression of pro-inflammatory cytokines and tissue factor in both monocytes and neutrophils. Notably, plasma concentrations of FHR-1, but not of factor H, were significantly (p |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::db31de9b855b6db54a3f46b54f33c487Test https://doaj.org/article/f4fef222f3624b56b6f873bb7fc7bb7aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....db31de9b855b6db54a3f46b54f33c487 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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