نتائج البحث

1

Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation ofBTBandCNCHomolog 2 by the MethyltransferaseEZH2

المؤلفون: Shingo Nakayamada, Masanobu Ueno, Tong Zhang, Mingzeng Zhang, Maiko Hajime, Naoaki Ohkubo, Shigeru Iwata, Hiroko Miyata, Jie Fan, Kaoru Yamagata, Yasuyuki Todoroki, He Hao, Yoshiya Tanaka

المصدر: Arthritis & Rheumatology. 72:1143-1153

مصطلحات موضوعية: Adult, Male, X-Box Binding Protein 1, 0301 basic medicine, Methyltransferase, Plasma Cells, Immunology, B-cell receptor, mTORC1, Mechanistic Target of Rapamycin Complex 1, CD19, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, Methionine, 0302 clinical medicine, Rheumatology, Interferon, medicine, Humans, Lupus Erythematosus, Systemic, Syk Kinase, Immunology and Allergy, Enhancer of Zeste Homolog 2 Protein, Amino Acids, Cells, Cultured, B cell, Autoantibodies, chemistry.chemical_classification, biology, Precursor Cells, B-Lymphoid, Cell Differentiation, Middle Aged, Amino acid, Cell biology, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, chemistry, Case-Control Studies, biology.protein, Female, Positive Regulatory Domain I-Binding Factor 1, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f83c76a30bddc46586697dcc78ae03Test
https://doi.org/10.1002/art.41208Test

2

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

المؤلفون: Kefu Wu, Xiaolin Yang, Kaifeng Shen, Yu-Jia Wei, Shi-Yong Liu, Jiong Yue, Jiaojiang He, Hui Yang, Chun-Qing Zhang

المصدر: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Journal of Neuroinflammation

مصطلحات موضوعية: Male, Pathology, Pyrrolidines, Anti-Inflammatory Agents, Hippocampus, Convulsants, lcsh:RC346-429, Mice, Status Epilepticus, Neuroinflammation, Gliosis, Temporal lobe epilepsy, Neocortex, TUNEL assay, Microglia, Neuronal apoptosis, General Neuroscience, Pilocarpine, Temporal Lobe, medicine.anatomical_structure, Neuroprotective Agents, Rev-Erbα, Neurology, Cytokines, Encephalitis, medicine.symptom, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Immunology, Status epilepticus, Thiophenes, Biology, Neuroprotection, Cellular and Molecular Neuroscience, Young Adult, medicine, Animals, Humans, lcsh:Neurology. Diseases of the nervous system, Research, NLRP3 inflammasome, Mice, Inbred C57BL, Epilepsy, Temporal Lobe, Gene Expression Regulation, nervous system, Nuclear Receptor Subfamily 1, Group D, Member 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a749cea093b9b3eda68c93cc429703bTest
https://doaj.org/article/a24c5daa2e23441fb73fa685c2ac36bcTest

3

Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1

المؤلفون: Nabeel Nabulsi, Yiyun Huang, Kelly P. Cosgrove, Ansel T. Hillmer, Steven M. Southwick, Shivani Bhatt, Soheila Najafzadeh, David Matuskey, John H. Krystal, Richard E. Carson, Michael Kapinos, Aleksandra Rusowicz, Gustavo A. Angarita

المصدر: J Clin Invest

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Hydrocortisone, behavioral disciplines and activities, Severity of Illness Index, Stress Disorders, Post-Traumatic, Immune system, Neuroimaging, 11β-hydroxysteroid dehydrogenase type 1, Internal medicine, mental disorders, 11-beta-Hydroxysteroid Dehydrogenase Type 1, medicine, Translocator protein, Radioligand, Humans, Veterans Affairs, biology, business.industry, Brain, General Medicine, Human brain, Middle Aged, Triazoles, medicine.anatomical_structure, Endocrinology, Positron-Emission Tomography, biology.protein, Female, Clinical Medicine, business, Glucocorticoid, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca884cb5ccb3978dec7ba228b5dc4fbTest
https://pubmed.ncbi.nlm.nih.gov/34651587Test

4

PD-1/PD-L1 immune checkpoint inhibitors in glioblastoma: clinical studies, challenges and potential

المؤلفون: Ziren Kong, Tianrui Yang, Wenbin Ma

المصدر: Hum Vaccin Immunother

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96468a3d995c5789af9069cfe8f275f6Test
https://doi.org/10.1080/21645515.2020.1782692Test

5

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

المؤلفون: Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik, Cassandra Balinas

المصدر: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-11 (2019)
Journal of Translational Medicine

مصطلحات موضوعية: 0301 basic medicine, Interleukin 2, Adult, Cytotoxicity, Immunologic, Male, Encephalomyelitis, Cell, TRPM Cation Channels, lcsh:Medicine, Stimulation, CD38, General Biochemistry, Genetics and Molecular Biology, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, TRPM2, Adenosine diphosphate ribose, Cyclic ADP-Ribose, Fatigue Syndrome, Chronic, biology, medicine.diagnostic_test, Chemistry, Research, lcsh:R, General Medicine, medicine.disease, ADP-ribosyl Cyclase 1, Killer Cells, Natural, Transient receptor potential melastatin 2, 030104 developmental biology, medicine.anatomical_structure, Myalgic encephalomyelitis/chronic fatigue syndrome, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Interleukin-2, Natural killer cells, Female, Calcium, Antibody, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e60c5262fe2d0a51f9918ac96c8c52Test
https://doaj.org/article/8cbd2da5d83c47c881241e44a3db55d5Test

6

Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes

المؤلفون: Yang Zhao, Qi Sun, Dan Weng, Junhao Liu, Yan Gao, Xi Xu, Shiming Wang, Jianfa Zhang, Xiao Yang, Wenhao Ge, Yunxia Yang

المصدر: Diabetologia. 62:2106-2117

مصطلحات موضوعية: Male, 0301 basic medicine, Magnetic Resonance Spectroscopy, Endocrinology, Diabetes and Metabolism, ATPase, Metabolite, Type 2 diabetes, Mice, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Adenine nucleotide, Homeostasis, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Nucleotides, Chemistry, Hydrogen-Ion Concentration, Middle Aged, Metformin, medicine.anatomical_structure, Liver, Hepatocyte, Female, medicine.drug, Adult, medicine.medical_specialty, Intracellular pH, 030209 endocrinology & metabolism, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Animals, Humans, Adenine, Cell Membrane, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Kinetics, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, Hyperglycemia, Hepatocytes, biology.protein, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc6b30d187dbefb8c8ad54a81b9d2dTest
https://doi.org/10.1007/s00125-019-04971Test-1

7

Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP

المؤلفون: Ashley Vellucci, Raya Massoud, Bonita R. Bryant, Joan Ohayon, Irene Cortese, Nyater Ngouth, Unsong Oh, Bridgette Jeanne Billioux, Steven Jacobson, Yoshimi Enose-Akahata, Thomas A. Waldmann

المصدر: Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1383-1394 (2019)
Annals of Clinical and Translational Neurology

مصطلحات موضوعية: 0301 basic medicine, Male, CD8-Positive T-Lymphocytes, Lymphocyte Activation, 0302 clinical medicine, immune system diseases, Tropical spastic paraparesis, Cytotoxic T cell, Research Articles, Interleukin-15, Human T-lymphotropic virus 1, biology, General Neuroscience, Antibodies, Monoclonal, virus diseases, Middle Aged, Paraparesis, Tropical Spastic, medicine.anatomical_structure, Interleukin 15, Cytokines, Administration, Intravenous, Female, Antibody, medicine.drug, Research Article, RC321-571, Interleukin 2, Adult, endocrine system, T cell, Neurosciences. Biological psychiatry. Neuropsychiatry, 03 medical and health sciences, Interferon-gamma, Immune system, medicine, Humans, RC346-429, Aged, business.industry, medicine.disease, HTLV-I Infections, Interleukin-2 Receptor beta Subunit, 030104 developmental biology, Immunology, biology.protein, Interleukin-2, Neurology (clinical), Neurology. Diseases of the nervous system, Nervous System Diseases, business, 030217 neurology & neurosurgery, CD8, T-Lymphocytes, Cytotoxic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22700b7405237f5b2f2dd1b39b2fdc93Test
https://doaj.org/article/c31238f4eb5643fcb7a998a29c16f641Test

8

Dietary intervention rescues myopathy associated with neurofibromatosis type 1

المؤلفون: Sandra T. Cooper, David A. Stevenson, Kate G. R. Quinlan, Ute Roessner, Aaron Schindeler, Thusitha T.W. Rupasinghe, David G. Little, Emily R Vasiljevski, Kathy Mikulec, Matthew A. Summers, Lauren Peacock, Frances J. Evesson

المصدر: Human Molecular Genetics. 27:577-588

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Neurofibromatosis 1, Adolescent, Mice, Transgenic, Mass Spectrometry, Mice, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Muscular Diseases, Carnitine, Internal medicine, Genetics, medicine, Animals, Humans, Child, Myopathy, Molecular Biology, Genetics (clinical), Mice, Knockout, Muscle Weakness, Neurofibromin 1, biology, Cholesterol, Fatty Acids, Muscle weakness, Skeletal muscle, Lipid metabolism, General Medicine, Lipid Metabolism, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Child, Preschool, Knockout mouse, Quality of Life, biology.protein, Female, medicine.symptom, 030217 neurology & neurosurgery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e831c8e9bbac43cf440366855af6e2Test
https://doi.org/10.1093/hmg/ddx423Test

9

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use

المصدر: J Am Soc Nephrol

مصطلحات موضوعية: Adult, Graft Rejection, Male, 0301 basic medicine, Benzylamines, medicine.medical_specialty, medicine.drug_class, Urology, 030230 surgery, Plasma cell, CD38, Cyclams, Monoclonal antibody, T-Lymphocytes, Regulatory, 03 medical and health sciences, 0302 clinical medicine, HLA Antigens, Heterocyclic Compounds, Isoantibodies, Animals, Humans, Medicine, Kidney transplantation, biology, business.industry, Plerixafor, Antibody-Dependent Cell Cytotoxicity, Antibodies, Monoclonal, Daratumumab, General Medicine, medicine.disease, ADP-ribosyl Cyclase 1, Kidney Transplantation, Macaca mulatta, Transplantation, Basic Research, 030104 developmental biology, medicine.anatomical_structure, Nephrology, biology.protein, Antibody, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8b47caca2a185f48d67aa6d4990731Test
https://doi.org/10.1681/asn.2018121254Test

10

Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy

المؤلفون: Elzinandes Leal de Azeredo, Helver Gonçalves Dias, Alba Grifoni, Débora Familiar-Macedo, Silvia Maria Baeta Cavalcanti, Alessandro Sette, Luzia Maria de-Oliveira-Pinto, Fabiana Rabe Carvalho, Renata Artimos de Oliveira Vianna, Caroline Fernandes dos Santos, Claudete Aparecida Araújo Cardoso, Alex Pauvolid-Corrêa, Daniela Weiskopf, Mariana Gandini, Solange Oliveira, Andrea Alice da Silva, Iury Amancio Paiva, Jessica Badolato Correa da Silva

المصدر: Viruses
Volume 13
Issue 2
Viruses, Vol 13, Iss 191, p 191 (2021)

مصطلحات موضوعية: Cytotoxicity, Immunologic, 0301 basic medicine, T-Lymphocytes, lcsh:QR1-502, chemokine receptors, lcsh:Microbiology, Zika virus, 0302 clinical medicine, Medicine, Cytotoxic T cell, Interferon gamma, 030212 general & internal medicine, Pregnancy Complications, Infectious, biology, medicine.diagnostic_test, Zika Virus Infection, ELISPOT, Pregnancy Outcome, inflammatory response, Infectious Diseases, medicine.anatomical_structure, Female, pregnancy, medicine.drug, Adult, Receptors, CCR5, T cell, CX3C Chemokine Receptor 1, T cells, Article, Flow cytometry, Interferon-gamma, Young Adult, 03 medical and health sciences, Immune system, Virology, Humans, ZIKV, cytotoxic activity, Pregnancy, business.industry, Infant, Lysosome-Associated Membrane Glycoproteins, Zika Virus, biology.organism_classification, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, Immunology, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9b1880874b6ad07d502a2434b5bd45Test

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