دورية أكاديمية
Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link?
| العنوان: | Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link? |
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| المؤلفون: | Ruiz-Fernández, Clara, Francisco, Vera, Pino, Jesus, Mera, Antonio, González-Gay Mantecón, Miguel Ángel, Gómez, Rodolfo, Lago, Francisca, Gualillo, Oreste |
| المساهمون: | Universidad de Cantabria |
| المصدر: | Int J Mol Sci. 2019 Apr 25;20(8). pii: E2030 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2019 |
| المجموعة: | Universidad de Cantabria: UCrea |
| مصطلحات موضوعية: | Adipokines, Adiponectin, Adipose tissue, Annulus fibrosus, Immune system, Intervertebral disc degeneration, Leptin, Metabolism, Nucleus pulposus, Obesity |
| الوصف: | Intervertebral disc degeneration (IVDD) is a chronic, expensive, and high-incidence musculoskeletal disorder largely responsible for back/neck and radicular-related pain. It is characterized by progressive degenerative damage of intervertebral tissues along with metabolic alterations of all other vertebral tissues. Despite the high socio-economic impact of IVDD, little is known about its etiology and pathogenesis, and currently, no cure or specific treatments are available. Recent evidence indicates that besides abnormal and excessive mechanical loading, inflammation may be a crucial player in IVDD. Furthermore, obese adipose tissue is characterized by a persistent and low-grade production of systemic pro-inflammatory factors. In this context, chronic low-grade inflammation associated with obesity has been hypothesized as an important contributor to IVDD through different, but still unknown, mechanisms. Adipokines, such as leptin, produced prevalently by white adipose tissues, but also by other cells of mesenchymal origin, particularly cartilage and bone, are cytokine-like hormones involved in important physiologic and pathophysiological processes. Although initially restricted to metabolic functions, adipokines are now viewed as key players of the innate and adaptative immune system and active modulators of the acute and chronic inflammatory response. The goal of this review is to summarize the most recent findings regarding the interrelationships among inflammation, obesity and the pathogenic mechanisms involved in the IVDD, with particular emphasis on the contribution of adipokines and their potential as future therapeutic targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| العلاقة: | https://www.doi.org/10.3390/ijms20082030Test; http://hdl.handle.net/10902/16947Test |
| DOI: | 10.3390/ijms20082030 |
| الإتاحة: | https://doi.org/10.3390/ijms20082030Test http://hdl.handle.net/10902/16947Test |
| حقوق: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license. ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.FBEEC925 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 14220067 |
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| DOI: | 10.3390/ijms20082030 |