Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers
| العنوان: | Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers |
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| المؤلفون: | Sharon M. Gorski, Svetlana Bortnik |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 18, Iss 7, p 1496 (2017) |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, autophagy, Review, Biology, Bioinformatics, medicine.disease_cause, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, cancer, Animals, Humans, Physical and Theoretical Chemistry, Treatment resistance, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Organic Chemistry, Autophagy, biomarkers, Cancer, General Medicine, medicine.disease, 3. Good health, Computer Science Applications, Clinical trial, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, 030220 oncology & carcinogenesis, immunohistochemistry, Biomarker (medicine), Carcinogenesis |
| الوصف: | Autophagy, a lysosome-mediated intracellular degradation and recycling pathway, plays multiple context-dependent roles in tumorigenesis and treatment resistance. Encouraging results from various preclinical studies have led to the initiation of numerous clinical trials with the intention of targeting autophagy in various cancers. Accumulating knowledge of the particular mechanisms and players involved in different steps of autophagy regulation led to the ongoing discovery of small molecule inhibitors designed to disrupt this highly orchestrated process. However, the development of validated autophagy-related biomarkers, essential for rational selection of patients entering clinical trials involving autophagy inhibitors, is lagging behind. One possible source of biomarkers for this purpose is the autophagy machinery itself. In this review, we address the recent trends, challenges and advances in the assessment of the biomarker potential of clinically relevant autophagy proteins in human cancers. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf1fe02910d98a56a55177b72de1525Test https://doi.org/10.3390/ijms18071496Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0cf1fe02910d98a56a55177b72de1525 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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