نتائج البحث

1

Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis

المؤلفون: Ronald F van Vollenhoven, Jonathan Aldridge, Anna-Karin H. Ekwall, Anna-Carin Lundell, Kerstin Andersson, Magnus Hallström, Anna Rudin, Inger Gjertsson

المصدر: Rheumatology. 61:1233-1242

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, medicine.medical_specialty, T cell, Programmed Cell Death 1 Receptor, Antibodies, Monoclonal, Humanized, Gastroenterology, Flow cytometry, Abatacept, Arthritis, Rheumatoid, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tocilizumab, Rheumatology, Internal medicine, Follicular phase, Humans, Medicine, CTLA-4 Antigen, Pharmacology (medical), Aged, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Methotrexate, 030104 developmental biology, medicine.anatomical_structure, chemistry, CTLA-4, Antirheumatic Agents, Rheumatoid arthritis, Certolizumab Pegol, Drug Therapy, Combination, business, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e2ee6099ecc9ff547a7210ae8a586dTest
https://doi.org/10.1093/rheumatology/keab454Test

2

Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation ofBTBandCNCHomolog 2 by the MethyltransferaseEZH2

المؤلفون: Shingo Nakayamada, Masanobu Ueno, Tong Zhang, Mingzeng Zhang, Maiko Hajime, Naoaki Ohkubo, Shigeru Iwata, Hiroko Miyata, Jie Fan, Kaoru Yamagata, Yasuyuki Todoroki, He Hao, Yoshiya Tanaka

المصدر: Arthritis & Rheumatology. 72:1143-1153

مصطلحات موضوعية: Adult, Male, X-Box Binding Protein 1, 0301 basic medicine, Methyltransferase, Plasma Cells, Immunology, B-cell receptor, mTORC1, Mechanistic Target of Rapamycin Complex 1, CD19, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, Methionine, 0302 clinical medicine, Rheumatology, Interferon, medicine, Humans, Lupus Erythematosus, Systemic, Syk Kinase, Immunology and Allergy, Enhancer of Zeste Homolog 2 Protein, Amino Acids, Cells, Cultured, B cell, Autoantibodies, chemistry.chemical_classification, biology, Precursor Cells, B-Lymphoid, Cell Differentiation, Middle Aged, Amino acid, Cell biology, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, chemistry, Case-Control Studies, biology.protein, Female, Positive Regulatory Domain I-Binding Factor 1, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f83c76a30bddc46586697dcc78ae03Test
https://doi.org/10.1002/art.41208Test

3

Decrease in the proportion of CD24hiCD38hi B cells and impairment of their regulatory capacity in type 1 diabetes patients

المؤلفون: Yao Qin, Xinyu Xu, Yueshu Wang, Mei Zhang, Jing Wang, Xing Wang, Heng Chen, Lingyu Zhang, Hsiang‐Ting Hsu

المصدر: Clin Exp Immunol

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Immunology, B-Lymphocyte Subsets, CD38, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, Interferon, Internal medicine, medicine, Humans, Immunology and Allergy, IL-2 receptor, Child, Cells, Cultured, B cell, B-Lymphocytes, Regulatory, Membrane Glycoproteins, Tumor Necrosis Factor-alpha, business.industry, CD24 Antigen, FOXP3, Original Articles, ADP-ribosyl Cyclase 1, Interleukin-10, Interleukin 10, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Female, Tumor necrosis factor alpha, business, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a753e8cc47c44e6af7f4b6f6c9d7436eTest
https://doi.org/10.1111/cei.13408Test

4

Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway

المؤلفون: Shiqi Wang, Zhongyan Shan, Qiong Wu, Xiaoli Wang, Xiaoguang Shi, Lei Zhao, Weiping Teng

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, T cell, immunometabolism, Tregs, Hashimoto Disease, HIF1a, Deoxyglucose, Thyroiditis, Diseases of the endocrine glands. Clinical endocrinology, Autoimmune thyroiditis, 03 medical and health sciences, Mice, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Animals, Humans, Glycolysis, Thyroiditis, Subacute, PI3K/AKT/mTOR pathway, Original Research, Aged, Glucose Transporter Type 1, Chemistry, TOR Serine-Threonine Kinases, Thyroid, Hashimoto’s thyroiditis, glycolysis, Middle Aged, Th1 Cells, medicine.disease, RC648-665, Hypoxia-Inducible Factor 1, alpha Subunit, Metformin, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, T cell differentiation, Th17 Cells, Female, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd9f08d28f4f66078993065e54d45caTest
http://europepmc.org/articles/PMC8211914Test

5

The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia

المؤلفون: Yabo Ouyang, Dexi Chen, Lijun Pang, Xianghua Guo, Ronghua Jin, Jiming Yin, Ying-Mei Feng, Hongbo Shi, Honglin Shi, Wenjing Wang, Luxin Qiao

المصدر: Cell Death and Disease, Vol 11, Iss 6, Pp 1-8 (2020)
Cell Death & Disease

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Lymphocyte, CD8-Positive T-Lymphocytes, 0302 clinical medicine, STAT5 Transcription Factor, Cytotoxic T cell, IL-2 receptor, Aged, 80 and over, lcsh:Cytology, Middle Aged, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Coronavirus Infections, medicine.drug, Interleukin 2, Adult, medicine.medical_specialty, T cell, Critical Illness, Immunology, Pneumonia, Viral, Peripheral blood mononuclear cell, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Betacoronavirus, Immune system, Internal medicine, medicine, Humans, Lymphocyte Count, lcsh:QH573-671, Pandemics, Aged, business.industry, SARS-CoV-2, Interleukins, Tumor Suppressor Proteins, Interleukin-2 Receptor alpha Subunit, COVID-19, Cell Biology, Janus Kinase 1, medicine.disease, Pneumonia, 030104 developmental biology, Viral infection, Interleukin-2, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54f768432e3b5857a30940e825993ceTest
http://link.springer.com/article/10.1038/s41419-020-2636-4Test

6

CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes

المؤلفون: Mark Harris, Ranjeny Thomas, Martin J. Hessner, Rhonda Geoffrey, Anne-Sophie Bergot, Breanna Lam, Kerry Buchanan, Elisavet Serti, Rosita Moya, Alessandra Mandelli, Irene Gotuzzo, Manuela Battaglia, Joanna D. Davies, Aditi Narsale, Benedetta Pessina, Gian Maria Giamporcaro, TingTing Lu

المصدر: JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Oncology, Autoimmune diseases, medicine.medical_treatment, Cell, Autoimmunity, medicine.disease_cause, 0302 clinical medicine, T-Lymphocyte Subsets, IL-2 receptor, Child, education.field_of_study, Diabetes, General Medicine, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, Disease Progression, Medicine, Female, Immunotherapy, Research Article, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Population, Immunology, T cells, Alefacept, Interleukin-7 Receptor alpha Subunit, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, medicine, Humans, education, Proportional Hazards Models, Type 1 diabetes, business.industry, Interleukin-2 Receptor alpha Subunit, Infant, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Multivariate Analysis, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ca9272dda4aa45bece327b8ae55f8Test
https://doaj.org/article/20ba8c4ce6b4454ea7c69dca229e3557Test

7

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

المؤلفون: Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik, Cassandra Balinas

المصدر: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-11 (2019)
Journal of Translational Medicine

مصطلحات موضوعية: 0301 basic medicine, Interleukin 2, Adult, Cytotoxicity, Immunologic, Male, Encephalomyelitis, Cell, TRPM Cation Channels, lcsh:Medicine, Stimulation, CD38, General Biochemistry, Genetics and Molecular Biology, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, TRPM2, Adenosine diphosphate ribose, Cyclic ADP-Ribose, Fatigue Syndrome, Chronic, biology, medicine.diagnostic_test, Chemistry, Research, lcsh:R, General Medicine, medicine.disease, ADP-ribosyl Cyclase 1, Killer Cells, Natural, Transient receptor potential melastatin 2, 030104 developmental biology, medicine.anatomical_structure, Myalgic encephalomyelitis/chronic fatigue syndrome, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Interleukin-2, Natural killer cells, Female, Calcium, Antibody, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e60c5262fe2d0a51f9918ac96c8c52Test
https://doaj.org/article/8cbd2da5d83c47c881241e44a3db55d5Test

8

Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes

المؤلفون: Yang Zhao, Qi Sun, Dan Weng, Junhao Liu, Yan Gao, Xi Xu, Shiming Wang, Jianfa Zhang, Xiao Yang, Wenhao Ge, Yunxia Yang

المصدر: Diabetologia. 62:2106-2117

مصطلحات موضوعية: Male, 0301 basic medicine, Magnetic Resonance Spectroscopy, Endocrinology, Diabetes and Metabolism, ATPase, Metabolite, Type 2 diabetes, Mice, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Adenine nucleotide, Homeostasis, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Nucleotides, Chemistry, Hydrogen-Ion Concentration, Middle Aged, Metformin, medicine.anatomical_structure, Liver, Hepatocyte, Female, medicine.drug, Adult, medicine.medical_specialty, Intracellular pH, 030209 endocrinology & metabolism, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Animals, Humans, Adenine, Cell Membrane, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Kinetics, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, Hyperglycemia, Hepatocytes, biology.protein, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc6b30d187dbefb8c8ad54a81b9d2dTest
https://doi.org/10.1007/s00125-019-04971Test-1

9

Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP

المؤلفون: Ashley Vellucci, Raya Massoud, Bonita R. Bryant, Joan Ohayon, Irene Cortese, Nyater Ngouth, Unsong Oh, Bridgette Jeanne Billioux, Steven Jacobson, Yoshimi Enose-Akahata, Thomas A. Waldmann

المصدر: Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1383-1394 (2019)
Annals of Clinical and Translational Neurology

مصطلحات موضوعية: 0301 basic medicine, Male, CD8-Positive T-Lymphocytes, Lymphocyte Activation, 0302 clinical medicine, immune system diseases, Tropical spastic paraparesis, Cytotoxic T cell, Research Articles, Interleukin-15, Human T-lymphotropic virus 1, biology, General Neuroscience, Antibodies, Monoclonal, virus diseases, Middle Aged, Paraparesis, Tropical Spastic, medicine.anatomical_structure, Interleukin 15, Cytokines, Administration, Intravenous, Female, Antibody, medicine.drug, Research Article, RC321-571, Interleukin 2, Adult, endocrine system, T cell, Neurosciences. Biological psychiatry. Neuropsychiatry, 03 medical and health sciences, Interferon-gamma, Immune system, medicine, Humans, RC346-429, Aged, business.industry, medicine.disease, HTLV-I Infections, Interleukin-2 Receptor beta Subunit, 030104 developmental biology, Immunology, biology.protein, Interleukin-2, Neurology (clinical), Neurology. Diseases of the nervous system, Nervous System Diseases, business, 030217 neurology & neurosurgery, CD8, T-Lymphocytes, Cytotoxic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22700b7405237f5b2f2dd1b39b2fdc93Test
https://doaj.org/article/c31238f4eb5643fcb7a998a29c16f641Test

10

Levamisole suppresses adipogenesis of aplastic anaemia‐derived bone marrow mesenchymal stem cells through ZFP36L1‐PPARGC1B axis

المؤلفون: Hao Zhang, Li-Na Wang, Panpan Cheng, Saisai Ren, Lulu Liu, Lei Liu, Cuiling Wang, Xiao‐Li Chen, Haihui Liu, Mingtai Chen, Cui-Yun Dou

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, peroxisome proliferator‐activated receptor gamma coactivator 1 beta, Adolescent, Primary Cell Culture, Adipose tissue, Bone Marrow Cells, 03 medical and health sciences, apalastic anaemia, Genes, Reporter, Coactivator, Adipocytes, medicine, Humans, Luciferases, Receptor, mesenchymal stem cells, levamisole, Adipogenesis, Chemistry, Mesenchymal stem cell, Anemia, Aplastic, RNA-Binding Proteins, Cell Differentiation, Original Articles, Cell Biology, Middle Aged, Levamisole, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Case-Control Studies, ZFP36L1, Cancer research, Molecular Medicine, Original Article, Female, Bone marrow, adipogenic differentiation, Butyrate Response Factor 1, Carrier Proteins, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d612fdfdcebaf059ec44654918dc422bTest
https://doi.org/10.1111/jcmm.13761Test

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