Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?
| العنوان: | Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit? |
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| المؤلفون: | Courtney Choutka, Cally J Ho, Jing Xu, Svetlana Bortnik, Katharina Rothe, Xiaoyan Jiang, Norman S. Chow, Sharon M. Gorski, Paalini Sathiyaseelan, Kevin C. Yang |
| المصدر: | Autophagy. 15:368-371 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Huntingtin, Apoptosis, Meeting Report, Endoplasmic-reticulum-associated protein degradation, Biology, 03 medical and health sciences, Neoplasms, Mitophagy, Autophagy, medicine, Animals, Humans, Molecular Biology, 030102 biochemistry & molecular biology, Neurodegeneration, Proteins, Cell Biology, medicine.disease, 3. Good health, 030104 developmental biology, HIF1A, Imatinib mesylate, Cancer research, MAP1LC3B |
| الوصف: | In its third edition, the Vancouver Autophagy Symposium presented a platform for vibrant discussion on the differential roles of macroautophagy/autophagy in disease. This one-day symposium was held at the BC Cancer Research Centre in Vancouver, BC, bringing together experts in cell biology, protein biochemistry and medicinal chemistry across several different disease models and model organisms. The Vancouver Autophagy Symposium featured 2 keynote speakers that are well known for their seminal contributions to autophagy research, Dr. David Rubinsztein (Cambridge Institute for Medical Research) and Dr. Kay F. Macleod (University of Chicago). Key discussions included the context-dependent roles and mechanisms of dysregulation of autophagy in diseases and the corresponding need to consider context-dependent autophagy modulation strategies. Additional highlights included the differential roles of bulk autophagy versus selective autophagy, novel autophagy regulators, and emerging chemical tools to study autophagy inhibition. Interdisciplinary discussions focused on addressing questions such as which stage of disease to target, which type of autophagy to target and which component to target for autophagy modulation. Abbreviations: AD: Alzheimer disease; AMFR/Gp78: autocrine motility factor receptor; CCCP: carbonyl cyanide m-chlorophenylhydrazone; CML: chronic myeloid leukemia; CVB3: coxsackievirus B3; DRPLA: dentatorubral-pallidoluysian atrophy; ER: endoplasmic reticulum; ERAD: ER-associated degradation; FA: focal adhesion; HCQ: hydroxychloroquine; HD: Huntingtin disease; HIF1A/Hif1α: hypoxia inducible factor 1 subunit alpha; HTT: huntingtin; IM: imatinib mesylate; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; NBR1: neighbour of BRCA1; OGA: O-GlcNAcase; PDAC: pancreatic ductal adenocarcinoma; PLEKHM1: pleckstrin homology and RUN domain containing M1; polyQ: poly-glutamine; ROS: reactive oxygen species; RP: retinitis pigmentosa; SNAP29: synaptosome associated protein 29; SPCA3: spinocerebellar ataxia type 3; TNBC: triple-negative breast cancer. |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e80b58c5ac05214724e64bd05ff495Test https://doi.org/10.1080/15548627.2018.1509609Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39e80b58c5ac05214724e64bd05ff495 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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