نتائج البحث - "mitochondrial outer membrane permeabilization"

1

Mitochondrial outer membrane permeabilization at the single molecule level

المؤلفون: Andreas Jenner, Ana J. García-Sáez, Shashank Dadsena

المصدر: Cellular and Molecular Life Sciences

مصطلحات موضوعية: Single-molecule techniques, Programmed cell death, Mitochondrial outer membrane permeabilization (MOMP), Apoptosis, Review, urologic and male genital diseases, Permeability, Molecular Imprinting, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Interaction network, Bcl-2 proteins, Protein Interaction Mapping, Fluorescence Resonance Energy Transfer, Animals, Humans, Protein Interaction Maps, Molecular Biology, Tissue homeostasis, 030304 developmental biology, Pharmacology, 0303 health sciences, Mitochondrial outer membrane permeabilization, Mechanism (biology), Chemistry, Intrinsic apoptotic pathway, Cell Biology, bacterial infections and mycoses, female genital diseases and pregnancy complications, Cell biology, Mitochondria, Proto-Oncogene Proteins c-bcl-2, Apoptotic cell death, Molecular Medicine, bacteria, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b9cc4cabb7e0a4470d199f71f3046Test
http://europepmc.org/articles/PMC8106609Test

2

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis

المؤلفون: Robert W. Nickells, Martin Redmon, Dennis Keefe, Joshua A. Grosser, Rachel L. Fehrman

المصدر: BMC Research Notes
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Science (General), QH301-705.5, Mitochondrial outer membrane permeabilization, Cell, Apoptosis, Mitochondrion, Elamipretide (SS31), General Biochemistry, Genetics and Molecular Biology, Q1-390, 03 medical and health sciences, 0302 clinical medicine, medicine, Staurosporine, Biology (General), bcl-2-Associated X Protein, biology, Chemistry, Cytochrome c, Intrinsic apoptosis, General Medicine, Elamipretide, Mitochondria, Cell biology, Research Note, 030104 developmental biology, medicine.anatomical_structure, BAX, biology.protein, Medicine, Mitochondrial fragmentation, Mitochondrial dysfunction, Oligopeptides, 030217 neurology & neurosurgery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4af6c2b33b3bbc0d549b091141f275Test
https://doi.org/10.1186/s13104-021-05613-9Test

3

Apoptotic caspases cut down the immunogenicity of radiation

المؤلفون: Lorenzo Galluzzi, Aitziber Buqué, Maria E. Rodriguez-Ruiz, Jitka Fucikova

المصدر: Oncoimmunology
OncoImmunology, Vol 8, Iss 11 (2019)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71825fe0466cc8b55e13cedcf68eda93Test
https://pubmed.ncbi.nlm.nih.gov/31646103Test

4

Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis

المصدر: Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1694, p 1694 (2020)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14f7d0a1503ffc60e1aa98b8b69c2deTest
http://hdl.handle.net/10852/82462Test

5

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

المؤلفون: Kushal Kumar Das, Ana J. García-Sáez, Thomas Brunner, Annika Hantusch, Markus Rehm

المصدر: Cell Death and Disease, Vol 9, Iss 4, Pp 1-13 (2018)
Cell Death & Disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7314f6c1c731748abb1f3e50938a57Test
http://link.springer.com/article/10.1038/s41419-018-0464-6Test

6

Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

المؤلفون: Li Yang, Aizhen Xiong, Wen-Xing Ding, Hua Wang, Hong-Min Ni, Xiao Yang, Zhengtao Wang, Hiromi Sesaki

المصدر: Redox Biology, Vol 12, Iss, Pp 264-273 (2017)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, Seph, Senephylline, ActD, Actinomycin D, Clinical Biochemistry, Apoptosis, Mitochondrion, Liver injury, MOMP, Mitochondrial outer membrane permeabilization, Biochemistry, EM, Electron microscopy, Mfn1, mitofusin 1, GTP Phosphohydrolases, Senecionine, chemistry.chemical_compound, Gene Knockout Techniques, Mice, 0302 clinical medicine, pJNK, Phosphorylated c-Jun N-terminal kinase, HM, Heavy membrane, CQ, Chloroquine, DHPAs, Dehydropyrrolizidine alkaloids, TMRM, Teramethylrhodamine methyl ester, GSH, Glutathione, LPS, Lipopolysaccharide, lcsh:QH301-705.5, Membrane Potential, Mitochondrial, lcsh:R5-920, Cytochrome c, CYP, Cytochrome P450, Alanine Transaminase, 3. Good health, Mitochondria, OPA1, optic atrophy 1, 030220 oncology & carcinogenesis, Drp1, Dynamin-related protein 1, JNK, c-Jun N-terminal kinase, DNA fragmentation, ZVAD-fmk, Carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone, Mitochondrial fission, Chemical and Drug Induced Liver Injury, H＆E, Hematoxylin and eosin, lcsh:Medicine (General), Microtubule-Associated Proteins, Research Paper, Dynamins, HRP, Horseradish peroxidase, Cell Survival, Drp1, Biology, Mfn2, mitofusin 2, Mitochondrial Proteins, 03 medical and health sciences, TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling, medicine, Animals, Humans, MMP, Mitochondrial membrane potential, Fragmentation (cell biology), PHH, Primary human hepatocyte, Pyrrolizidine Alkaloids, MAPK, Mitogen-activted protein kinases, Organic Chemistry, ALT, Alanine aminotransferase, Mdivi-1, Mitochondrial division inhibitor-1, HSEC, hepatic sinusoidal endothelial cells, medicine.disease, Molecular biology, PAs, Pyrrolizidine alkaloids, Disease Models, Animal, 030104 developmental biology, chemistry, lcsh:Biology (General), GAPDH, Glyceradehyde-3-phosphate dehydrogenase, biology.protein, Hepatocytes, DHR, dehydroretronecine, HSOS, Hepatic sinusoidal syndrome, Sene, Senecionine, PFA, paraformaldehyde, ROS, Reactive oxygen species, VDAC, Voltage-dependent anion channel

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e6428ec7632340316ab8afa41ea60Test
http://www.sciencedirect.com/science/article/pii/S2213231717300745Test

7

Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink

المؤلفون: Alexey S. Ladokhin

المصدر: Cells
Cells, Vol 9, Iss 2121, p 2121 (2020)

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, 2019-20 coronavirus outbreak, protein–membrane interactions, Antineoplastic Agents, Biology, Pathogenesis, Bcl-2 proteins as therapeutic targets, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, cancer, lcsh:QH301-705.5, mitochondrial outer membrane permeabilization, Sulfonamides, Mitochondrial outer membrane permeabilization, Bcl-2 family, apoptosis, Cancer, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Mitochondria, Cell biology, Gene Expression Regulation, Neoplastic, Editorial, 030104 developmental biology, lcsh:Biology (General), Proto-Oncogene Proteins c-bcl-2, Apoptosis, 030220 oncology & carcinogenesis, Mitochondrial Membranes, Homeostasis, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98367e38fd5d6ea860d79dbb9034c297Test
https://doi.org/10.3390/cells9092121Test

8

How to unleash mitochondrial apoptotic blockades to kill cancers?

المؤلفون: Jing Deng

المصدر: Acta Pharmaceutica Sinica B, Vol 7, Iss 1, Pp 18-26 (2017)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, BTK, Bruton׳s tyrosine kinase, T-ALL, T-acute lymphocytic leukemia, Apoptosis, Review, PI3K, phosphatidylinositol-3-kinase, Targeted therapy, NIH, National Institutes of Health, ERK, extracellular signal-regulated kinase, GSK-3, MOMP, mitochondrial outer membrane permeabilization, BCL-2 family, CML, chronic myelogenous leukemia, General Pharmacology, Toxicology and Pharmaceutics, CDK, cyclin-dependent kinase, CLL, chronic lymphocytic leukemia, BAX, BCL-2-associated X protein, GSK-3, glycogen synthase kinase-3, Cell biology, NHL, non-Hodgkin lymphoma, BOK, BCL-2 related ovarian killer, BCL-xL, B-cell lymphoma X long, Programmed cell death, CHOP, cyclophosphamide, hydroxydaunorubicin, oncovin-vincristine and prednisone, FDA, U. S. Food and Drug Administration, PUMA, p53 up-regulated modulator of apoptosis, ASH, American Society of Hematology, BID, BH3 interacting domain death agonist, BH3 profiling, Bcl-xL, BIM, BCL-2-interacting mediator of cell death, Biology, BCL-w (BCL2L2), BCL-2-like protein 2, BCR, B-cell receptor, ER, endoplasmic reticulum, 03 medical and health sciences, Mitochondrial priming, Cyclin-dependent kinase, SLL, small lymphocytic lymphoma, NSCLC, non-small cell lung cancer, Combination therapy, PI3K/AKT/mTOR pathway, ITK, interleukin-2-inducible T-cell kinase, BH3, BCL-2 homology 3, Bcl-2 family, lcsh:RM1-950, ATAP, amphipathic tail-anchoring peptide, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, biology.protein, BAD, BCL-2-associated death promoter protein, MCL, myeloid cell leukemia, BAK, BCL-2 homologous antagonist killer, BCL-2, B-cell lymphoma 2, BFL-1 (BCL2A1), BCL-2-related protein A1, BIK, BCL-2-interacting killer, CR, complete response, EGFR, epidermal growth factor receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd33a3c642c227ee36c739b38c6e8328Test

9

Deadly Encounter: Endosomes Meet Mitochondria to Initiate Apoptosis

المؤلفون: Mariella Vicinanza, David C. Rubinsztein

المصدر: Developmental Cell. 53:619-620

مصطلحات موضوعية: 0303 health sciences, Mitochondrial outer membrane permeabilization, Endosome, Cell Biology, Mitochondrion, Biology, urologic and male genital diseases, General Biochemistry, Genetics and Molecular Biology, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Apoptosis, Apoptotic cell death, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4f0e46dad352e3d7c1ada53ba7b73ad9Test
https://doi.org/10.1016/j.devcel.2020.05.030Test

10

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

المؤلفون: Zhi Zhang, Dang Nguyen, Xiaoke Chi, David W. Andrews, Elizabeth J Osterlund, Hetal Brahmbhatt, Brian Leber, James M. Pemberton, Jialing Lin, Qian Liu

المصدر: eLife
eLife, Vol 9 (2020)

مصطلحات موضوعية: 0301 basic medicine, Structural Biology and Molecular Biophysics, Mutant, Sequence (biology), Mitochondrion, 0302 clinical medicine, hemic and lymphatic diseases, Biology (General), Inner mitochondrial membrane, Cells, Cultured, bcl-2-Associated X Protein, mitochondrial outer membrane permeabilization, Cerebral Cortex, Neurons, 0303 health sciences, Bcl-2-Like Protein 11, Chemistry, General Neuroscience, apoptosis, General Medicine, BMK cells, Cell biology, Mitochondria, Membrane, 030220 oncology & carcinogenesis, Mitochondrial Membranes, Molecular mechanism, Medicine, biological phenomena, cell phenomena, and immunity, Research Article, QH301-705.5, Science, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Protein Domains, None, Animals, Humans, MEF cells, 030304 developmental biology, General Immunology and Microbiology, Molecular biophysics, Cell Biology, HCT116 Cells, nervous system diseases, Bcl-2 family proteins, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, Structural biology, Apoptosis, primary murine neurons

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fea2501e20063cec39d32828271031dTest
https://pubmed.ncbi.nlm.nih.gov/31976859Test

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