المؤلفون: Vieux M. Mokoli, Pierre Akilimali, François M. Kajingulu, Jean-Robert Makulo, Yannick Mompango Engole, Jeannine Luse, Nazaire M. Nseka, Marie-Noelle Wameso, Justine B. Bukabau, François B. Lepira, Augustin Luzayadio Longo, Mélanie Bavassa, Aliocha Nkodila, Chantal V. Zinga, Yannick Mayamba Nlandu, Ernest Kiswaya Sumaili

المصدر: BMC Nephrology, Vol 18, Iss 1, Pp 1-6 (2017)
BMC Nephrology

مصطلحات موضوعية: Nephrology, Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, 030232 urology & nephrology, Blood Pressure, 030204 cardiovascular system & hematology, lcsh:RC870-923, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Renal Dialysis, Statistical significance, Internal medicine, Black people, Epidemiology, medicine, Humans, Chronic hemodialysis, Stroke, Reverse epidemiology, Aged, business.industry, Incidence (epidemiology), Incidence, Middle Aged, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, Hemodialysis, Hypertension, Kidney Failure, Chronic, Female, business, Historical Cohort, Follow-Up Studies, Research Article

الوصف: Background Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective of this study was to assess the extent of stroke in chronic hemodialysis patients. Methods Historical cohort of patients enrolled in two hemodialysis (HD) centers from January 1, 2010 to December 31, 2011, including 191 patients (mean age 52 years, 68% men). Incidence curves and survival time analysis between the first day of HD and the end of the study were described by the Kaplan-Meier method. Independent stroke predictors were identified by multiple logistic regression analysis. P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7924df526e532c17f6a8a1686e910c2Test
http://link.springer.com/article/10.1186/s12882-017-0697-0Test

المؤلفون: Karen Efombola Itokua, Yannick Mayamba Nlandu, Pépé Mfutu Ekulu, Augustin Luzayadio Longo, François B. Lepira, François M. Kajingulu, Jean Robert R. Makulo, Nazaire M. Nseka, Chantal V. Zinga, Justine B. Bukabau, Vieux M. Mokoli, René M. Ngiyulu, Jean Lambert Gini, Pierre Akilimali, Michel Ntetani Aloni, Yannick Mompango Engole, Ernest Kiswaya Sumaili

المصدر: BMC Nephrology

مصطلحات موضوعية: Male, 030204 cardiovascular system & hematology, Leukocyte Count, chemistry.chemical_compound, Superoxide Dismutase-1, 0302 clinical medicine, Child, GPx, biology, medicine.diagnostic_test, Homozygote, Lactate dehydrogenase, Sickle cell anemia, Nephrology, Child, Preschool, Creatinine, 030220 oncology & carcinogenesis, Serum iron, Female, medicine.symptom, Cu-Zn SOD, Research Article, medicine.medical_specialty, Adolescent, Anemia, Sickle Cell, Hemolysis, 03 medical and health sciences, Internal medicine, Fetal hemoglobin, medicine, Albuminuria, Humans, Inflammation, Glutathione Peroxidase, L-Lactate Dehydrogenase, business.industry, medicine.disease, Ferritin, Oxidative Stress, Cross-Sectional Studies, Endocrinology, chemistry, Immunology, biology.protein, Microalbuminuria, Hemoglobin, business, Biomarkers

الوصف: Background Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes. Methods We consecutively recruited Steady state children aged between 2 and 18 years old with established diagnosis of homozygous SCA in two hospitals of Kinshasa/DR Congo. The relationship between Urinary Albumin Creatinine Ratio (UACR) and other variables of interest (age, systolic blood pressure, diastolic blood pressure, plasma GPx and Cu-Zn SOD, free plasmatic hemoglobin, LDH, indirect bilirubin, white blood cells (WBC), percentage of fetal hemoglobin, serum iron, ferritin, CRP) was analyzed by Bivariate correlation (Pearson’s correlation coefficient). Microalbuminuria was defined by urine albumin/creatinine ratio between 30 and 299 mg/g. Results Seventy Steady state Black African children with SCA (56% boys; average age 9.9 ± 4.3 years; 53% receiving hydroxyurea) were selected. Prevalence of microalbuminuria was 11.8%. LDH (r = 0.260; p = 0.033) and WBC count (r = 0.264; p = 0.033) were positively correlated with UACR whereas GPx (− 0.328; p = 0.007) and Cu-Zn SOD (− 0.210; p = 0.091) were negatively correlated with UACR. Conclusions Albuminuria is associated with decreased antioxidant capacity and increased levels of markers of hemolysis and inflammation. Therefore, strategies targeting the reduction of sickling and subsequent hemolysis, oxidative stress and inflammation could help preventing or at least delaying the progression of kidney disease in SCA children.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4f417c5f1c56ae7a79131fc2986ffcTest
https://doi.org/10.1186/s12882-016-0398-0Test

المؤلفون: Michel Ntetani Aloni, Pierre Akilimali, Jean Marie Mbuyi-Muamba, Tite Minga Mikobi, Prosper Lukusa Tshilobo, Georges Mvumbi-Lelo

المصدر: Journal of clinical laboratory analysis. 31(6)

مصطلحات موضوعية: Microbiology (medical), Adult, Male, medicine.medical_specialty, Globulin, Adolescent, Clinical Biochemistry, Alpha (ethology), Anemia, Sickle Cell, Overweight, Asymptomatic, Gastroenterology, Body Mass Index, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Fetal hemoglobin, medicine, Immunology and Allergy, Humans, Child, Fetal Hemoglobin, Research Articles, biology, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, Hematology, medicine.disease, Sickle cell anemia, Medical Laboratory Technology, Cross-Sectional Studies, Phenotype, 030220 oncology & carcinogenesis, Immunology, biology.protein, Democratic Republic of the Congo, Female, Hemoglobin, medicine.symptom, business, Body mass index, 030215 immunology

الوصف: Background The influence of phenotype on the clinical course and laboratory features of sickle cell anemia (SCA) is rarely described in sub-Saharan Africa. Methods A cross-sectional study was conducted in Kinshasa. A clinical phenotype score was built up. The following definitions were applied: asymptomatic clinical phenotype (ACP; score≤5), moderate clinical phenotype (MCP; score between 6 and 15), and severe clinical phenotype (SCP; score≥16). ANOVA test were used to compare differences among categorical variables. Results We have studied 140 patients. The mean body mass index (BMI) value of three groups was lower (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932f76d8346deda82213ab39885ee1b4Test
https://pubmed.ncbi.nlm.nih.gov/28116772Test

المؤلفون: Pierre Akilimali, Benoit Obel Kabengele, Didine Kinkodi Kaba, Jean-Marie Ntumba Kayembe, Zacharie Munogolo Kashongue, Patrick K. Kayembe

المصدر: PLoS ONE, Vol 14, Iss 4, p e0215530 (2019)

مصطلحات موضوعية: Adult, Male, Spirometry, medicine.medical_specialty, Allergy, Adolescent, Cross-sectional study, Science, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Forced Expiratory Volume, Internal medicine, Prevalence, Vitamin D and neurology, Animals, Humans, Medicine, 030212 general & internal medicine, Skin Tests, Asthma, Multidisciplinary, medicine.diagnostic_test, business.industry, Public health, Heartburn, Middle Aged, medicine.disease, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, Democratic Republic of the Congo, Female, medicine.symptom, business

الوصف: BackgroundThe ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).ObjectiveTo determine the socio-demographic, environmental, clinical, and biological factors and comorbidities associated with uncontrolled adult asthma in Kinshasa, DRC.MethodsWe performed a cross-sectional study of 216 male and female asthmatics aged 18 and over consecutively recruited from tertiary clinics and the community in Kinshasa between June 2017 and February 2018. For each subject, socio-demographic, clinical, para clinical and environmental data were recorded. Forced Expiratory Volume in one second (FEV1) values were obtained by Spirometry, allergen testing performed using the skin prick test, serum vitamin D levels measured by radioimmunoassay, and asthma control assessed using the asthma control test (ACT) score. Multiple logistic regression identified factors associated with uncontrolled asthma.ResultsThe average age of participants was 45.2 (SD 17.6) years, 74% were female, and 42% had a low educational level. Among all asthmatics, the prevalence of uncontrolled asthma was 56%, abnormal serum vitamin D level 95%, abnormal FEV1 65%, sensitization to two allergens (cat dander and dust mites) 18%, sleep disorders 37%, and heartburn 60%. Male (aOR 2.24; 95% CIs 1.04-4.79), low educational level (aOR 3.26; 95% CIs 1.54-6.67), sensitization to both cat dander and dust mites (aOR 2.67; 95% CIs 1.16-6.14), FEV1 ≤80% (aOR 2.07; 95% CIs 1.08-3.96), abnormal serum vitamin D level (aOR 5.11; 95% CIs 1.17-22.33), sleep disorders (aOR 1.96; 95% CIs 1.04-3.71), and heartburn (aOR 2.02; 95% CIs 1.04-3.92) were significantly associated with uncontrolled asthma.ConclusionUncontrolled asthma is common in Kinshasa, and these factors associated with uncontrolled asthma may be considered as targets for future intervention strategies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e287fcb5b2e66e7934500b331442715Test
https://doi.org/10.1371/journal.pone.0215530Test