التفاصيل البيبلوغرافية
| العنوان: |
Context Dependent Role of P53 Up-Regulated Modulator of Apoptosis (Puma) During Liver Degeneration and Regeneration |
| المؤلفون: |
Subhrajit Biswas* |
| بيانات النشر: |
MedCrave |
| سنة النشر: |
2016 |
| المجموعة: |
MedCrave |
| مصطلحات موضوعية: |
Hepatocytes, Liver Apoptosis, Lymphomagenesis, Tumorigenesis, Dietary Antigens, PUMA, P53 Up-Regulated Modulator of Apoptosis, HCC, Hepatocellular Carcinoma, DEN, Di Ethyl Nitrosamine, PH, Partial Hepatectomy, ROS, Reactive oxygen species, MOMP, Mitochondrial Outer Membrane Permeabilization, ALD, Alcoholic Liver Diseases, NAFLD, Non Alcoholic Liver Diseases Comprising Fatty Liver Diseases, NASH, Non-Alcoholic Steatohepatitis, HBV, Hepatitis B Virus, HCV, Hepatitis C Virus, ACLF, Acute on Chronic Liver Failure, ER |
| الوصف: |
Hepatocytes are susceptible to injury due to its contribution in xenobiotic metabolism including drugs and alcohol, fatty acid metabolism and enterohepatic circulation of bile acids and hepato tropic viruses. On the other hand regeneration of hepatocytes is well-studied phenomenon essential for maintenance of its volume during chronic liver injury as well as acute restoration of liver volume after resection. During chronic and acute insult of liver apoptosis and necrosis are the most widely documented forms of hepatocyte cell death. Experimental evidence also demonstrates that apoptosis and cell proliferation are closely linked and many proteins that can induce cell death are, in fact, components of the cell division cycle. Apoptosis is crucial for sustain tissue homeostasis and its circumvention is assumed as a hallmark of cancer. Conversely, there are several evidences also support the contribution of pro-apoptotic Bcl-2 family members in development of liver cancer. They also play vital role during liver regenerationinduced by partial hepatectomy, awell characterized in vivo model of cell cycleprogression. Here we discuss the context dependent role of specifically one BH3 only group of Bcl-2 family member, Puma during hepatic degeneration and regeneration. Up regulation and down regulation of this specific protein is vital for carcinogenesis as well as hepatic regeneration. The expression levels of Puma contributing to hepatocyte injuries, hepatic proliferation and progression of malignancies are also reflected in the context of potential therapeutic strategies. |
| نوع الوثيقة: |
review |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://medcraveonline.com/JLRDT/JLRDT-02-00027.phpTest |
| الإتاحة: |
http://medcraveonline.com/JLRDT/JLRDT-02-00027.phpTest |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.9D1C9B69 |
| قاعدة البيانات: |
BASE |
