التفاصيل البيبلوغرافية
| العنوان: |
Novel evidence for the role of monomeric C reactive protein and WISP2 in the modulation of catabolic and inflammatory response in cartilage and intervertebral disc |
| المؤلفون: |
Ruiz Fernández, Clara |
| المساهمون: |
Gualillo, Oreste, Pino Minguez, Jesús, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina |
| المجموعة: |
Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
| مصطلحات موضوعية: |
intervertebral disc degeneration, osteoarthritis, inflammation, adipokines, monomeric C reactive protein, 230221 Biología molecular, 230204 Genética bioquímica, 230216 Inmunoquímica |
| الوصف: |
Low back pain and osteoarthritis (OA) are the two main musculoskeletal diseases cause of disability worldwide, and intervertebral disc degeneration (IVDD) is considered the main cause of low back pain. A sustained inflammatory and catabolic state has been related to the origin and progression of both, OA and IVDD. This research work introduces monomeric C reactive protein (mCRP) pro-inflammatory and catabolic effects in healthy and degenerative human intervertebral disc cells and chondrocytes, suggesting its possible role in the pathophysiology of OA and IVDD. Furthermore, this thesis describes the adipokine WISP2 relevant roles in modulating the turnover of extracellular matrix in cartilage and how its downregulation may detrimentally alter the inflammatory environment in OA joints. |
| نوع الوثيقة: |
doctoral or postdoctoral thesis |
| اللغة: |
English |
| العلاقة: |
http://hdl.handle.net/10347/31505Test |
| الإتاحة: |
http://hdl.handle.net/10347/31505Test |
| حقوق: |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; open access |
| رقم الانضمام: |
edsbas.D95ADAD5 |
| قاعدة البيانات: |
BASE |
