كتاب
Systems Biology Approaches to the Study of Apoptosis
| العنوان: | Systems Biology Approaches to the Study of Apoptosis |
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| المؤلفون: | Huber, Heinrich, Bullinger, Eric, Rehm, Markus |
| المصدر: | urn:isbn:978-1-60327-380-0 ; Essentials of Apoptosis, 2nd Edition, 283-297 (2009-07-01) |
| بيانات النشر: | Humana press |
| سنة النشر: | 2009 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | apoptosis, systems biology, computational modeling, caspases, inhibitor-of-apoptosis proteins, death receptors, mitochondrial outer membrane permeabilization, apoptosome, Life sciences, Sciences du vivant |
| الوصف: | Today, we can avail of comprehensive information on the molecular mechanisms of apoptosis signaling that was gathered during decades of intense research. This chapter presents how mathematical approaches in the field of cellular signaling are used to integrate this complex and heterogeneous information into computational models with the aim to elucidate the functional properties of apopto- tic signaling networks. Mathematical modeling allows one to describe properties of signaling systems that emanate from the interplay of the system’s individual compo- nents and has a longstanding and successful history in the fields of physics, chemistry, and their applied engineering sciences. Systems analyses can serve to describe and identify signaling dynamics,molecular switches, thresholds, and feedback regulatory mechanisms and allow systems properties such as stability and robustness toward external perturbations to be identified. Crucially, systems analyses can also serve to generate novel qualitative and quantitative research hypotheses, which in turn allow for more focused experimental research approaches. This chapter provides a concise and critical overview on the current state of systems biology in the field of apoptotic signaling and the methodology employed. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-1-60327-380-0 1-60327-380-8 |
| العلاقة: | https://orbi.uliege.be/handle/2268/19667Test; info:hdl:2268/19667; scopus-id:2-s2.0-77958507226 |
| DOI: | 10.1007/978-1-60327-381-7_12 |
| الإتاحة: | https://doi.org/10.1007/978-1-60327-381-7_12Test https://orbi.uliege.be/handle/2268/19667Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.485A75B |
| قاعدة البيانات: | BASE |
| ردمك: | 9781603273800 1603273808 |
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| DOI: | 10.1007/978-1-60327-381-7_12 |