التفاصيل البيبلوغرافية
| العنوان: |
Assessing Neuronal Metabolism In Vivo by Modeling Imaging Measures. |
| المؤلفون: |
Ciccarelli, Olga1 o.ciccarelli@ion.ucl.ac.uk, Toosy, Ahmed T.1, de Stefano, Nicola2, Wheeler-Kingshott, Claudia A. M.3, Miller, David H.3, Thompson, Alan J.1 |
| المصدر: |
Journal of Neuroscience. 11/10/2010, Vol. 30 Issue 45, p15030-15033. 4p. |
| مصطلحات موضوعية: |
*NEUROPLASTICITY, *MICRODIALYSIS, *MITOCHONDRIAL pathology, *MULTIPLE sclerosis, *ACAMPROSATE, *AXONAL transport |
| مستخلص: |
Mitochondrial dysfunction contributes to the pathogenesis of many neurological diseases, including multiple sclerosis (MS), but is not directly measurable in vivo. We modeled N-acetyl-aspartate (NAA), which reflects axonal structural integrity and mitochondrial metabolism, with imaging measures of axonal structural integrity (axial diffusivity and cord cross-sectional area) to extract its mitochondrial metabolic contribution. Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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