Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
| العنوان: | Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway |
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| المؤلفون: | Seo Yeon Jin, Dong Hyung Lee, Seung-Hoon Baek, Hye Sun Lee, Sun Sik Bae, Young-Hwan Kim, Hwa Kyoung Shin, Sang Heon Song, Jung Min Ha, Sun Ja Kim, Chi Dae Kim |
| المصدر: | Experimental & Molecular Medicine |
| بيانات النشر: | Nature Publishing Group, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Angiogenesis, Clinical Biochemistry, Phospholipase C beta, Neovascularization, Physiologic, Phospholipase, Biology, Biochemistry, Umbilical vein, Neovascularization, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, Gene Silencing, Molecular Biology, Cell Proliferation, Tube formation, Phospholipase C, Retinal Vessels, Retinal, Cell biology, Endothelial stem cell, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, medicine.symptom, Signal Transduction |
| الوصف: | Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis. |
| اللغة: | English |
| تدمد: | 2092-6413 1226-3613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0528405a5527275bc8c37a45eeac6366Test http://europepmc.org/articles/PMC4929692Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0528405a5527275bc8c37a45eeac6366 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926413 12263613 |
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