Action of Cyclooxygenase Inhibitors and a Leukotriene Biosynthesis Inhibitor on Cisplatin-Induced Acute and Delayed Emesis in the Ferret
| العنوان: | Action of Cyclooxygenase Inhibitors and a Leukotriene Biosynthesis Inhibitor on Cisplatin-Induced Acute and Delayed Emesis in the Ferret |
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| المؤلفون: | Tasia S.W. Sam, Denis Riendeau, Annette Robichaud, John A. Rudd, Man P. Ngan |
| المصدر: | Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 189-200 (2007) |
| بيانات النشر: | Japanese Pharmacological Society, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Leukotrienes, Fever, Vomiting, Indomethacin, Antineoplastic Agents, Pharmacology, Dexamethasone, Lipoxygenase, medicine, Animals, Cyclooxygenase Inhibitors, Retching, Cisplatin, Leukotriene, Cyclooxygenase 2 Inhibitors, biology, Chemistry, lcsh:RM1-950, Ferrets, Drug Combinations, lcsh:Therapeutics. Pharmacology, Hyperalgesia, Indans, Prostaglandins, biology.protein, Leukotriene Antagonists, Molecular Medicine, Cyclooxygenase, medicine.symptom, Orchiectomy, medicine.drug |
| الوصف: | Cisplatin at 5 mg/kg, i.p. induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the anti-emetic activity of the non-selective cyclooxygenase inhibitor indomethacin (3 – 30 mg/kg, i.p., three times per day) and two cyclooxygenase-2 inhibitors, DFU [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone; 1 – 10 mg/kg, i.p. administered at 40 and 48 h] and L-745,337 [5-methanesulphonamido-6-(2,4-diflurothiophenyl)-1-indanone; 10 mg/kg, i.p., administered at 40 and 48 h]. Only indomethacin potentiated significantly cisplatin-induced retching + vomiting (P0.05). However, indomethacin alone (30 mg/kg) also induced emesis (P0.05). The combination treatment of indomethacin (10 mg/kg, i.p., three times per day) with MK-886 (10 mg/kg, i.p., three times per day) did not antagonize cisplatin-induced acute delayed retching + vomiting and had a different profile compared to the action of dexamethasone (1 mg/kg, i.p., three times per day; P |
| تدمد: | 1347-8648 1347-8613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaeaf9c8004db1b6c7229a956f7ea60dTest https://doi.org/10.1254/jphs.fp0061169Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eaeaf9c8004db1b6c7229a956f7ea60d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13478648 13478613 |
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