Platelet Aggregation and Vasoconstriction Related to Platelet Cyclooxygenase and 12-Lipoxygenase Pathways
| العنوان: | Platelet Aggregation and Vasoconstriction Related to Platelet Cyclooxygenase and 12-Lipoxygenase Pathways |
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| المؤلفون: | Tsutomu Michibayashi |
| المصدر: | Journal of Atherosclerosis and Thrombosis. 12:154-162 |
| بيانات النشر: | Japan Atherosclerosis Society, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Platelet Aggregation, Vasodilator Agents, Pharmacology, Arachidonate 12-Lipoxygenase, Tissue Culture Techniques, Norepinephrine, chemistry.chemical_compound, Lipoxygenase, Internal Medicine, medicine, Animals, Vasoconstrictor Agents, Platelet, Platelet Activating Factor, Platelet-activating factor, biology, Biochemistry (medical), Ear, Thromboxane B2, Nordihydroguaiaretic acid, chemistry, Prostaglandin-Endoperoxide Synthases, Regional Blood Flow, Vasoconstriction, Anesthesia, Prostaglandins, Tetrodotoxin, biology.protein, Collagen, Rabbits, Cyclooxygenase, medicine.symptom, Cardiology and Cardiovascular Medicine, Perfusion |
| الوصف: | Many thrombotic angiopathies originate as a result of an abnormal interaction between platelets and blood vessel walls. The present study focused on the platelet activating factor (PAF)-induced platelet aggregation mechanism and was undertaken to clarify the association between platelet aggregation and vasocontractility. Vasoconstriction was examined in perfused artery segments dissected from the central ear artery of male rabbits. Autologous platelet rich plasma (PRP) was infused into the perfusion system. Vasocontractility was examined in response to PRP plus PAF or collagen. The vasocontractile response to noradrenaline (NA-R) on perfusion of PRP plus PAF was initially augmented, then gradually attenuated. The platelet aggregation in response to PAF was constant and longlasting and moderately inhibited by nordihydroguaiaretic acid, a 12-lipoxygenase (LOX) inhibitor, but was unaffected by indomethacin, a cyclooxygenase inhibitor. The attenuated responses disappeared and NA-R was returned to the initial level on pretreatment with tetrodotoxin which excluded neurogenic components from the arterial preparation. In contrast, a repetitive NA-R to PRP plus collagen gradually increased. Thus, it may be concluded that PAF-induced platelet aggregation participates in activation of the 12-LOX pathway and is accompanied by the release of vasodepressor nerve-stimulating substances from platelets. |
| تدمد: | 1880-3873 1340-3478 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bcbb72adbe4de6ade1fc1ac3a107edTest https://doi.org/10.5551/jat.12.154Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c2bcbb72adbe4de6ade1fc1ac3a107ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18803873 13403478 |
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