Effect of physiological parameters on glucose microcirculation compartmental model in glucose monitoring
| العنوان: | Effect of physiological parameters on glucose microcirculation compartmental model in glucose monitoring |
|---|---|
| المؤلفون: | Luo Lu, Ting Shi, Yiming Zhang |
| المصدر: | Biotechnology & Biotechnological Equipment, Vol 32, Iss 4, Pp 1047-1052 (2018) |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood glucose monitoring, model, medicine.diagnostic_test, Chemistry, lcsh:Biotechnology, Diffusion, interstitial, Vascular permeability, Blood flow, Microcirculation, 03 medical and health sciences, Glucose, 030104 developmental biology, physiological parameters, Interstitial fluid, lcsh:TP248.13-248.65, medicine, continuous blood glucose monitoring, Biotechnology, Biomedical engineering |
| الوصف: | A glucose microcirculation compartmental model (GMCM) for predicting blood glucose concentrations from the reference interstitial fluid (ISF) glucose concentrations was proposed before. It was used to compensate the delay error in ISF in order to improve the prediction accuracy and to facilitate the clinical application of continuous blood glucose monitoring. In this paper, many physiological parameters in GMCM reflecting delay and transport properties were discussed in details. The significance and influence of the parameters, diffusion distance (x), pressure gradient-driven transport ratio (RStarling), blood flow velocity (F), glucose capillary permeability (P), glucose diffusion coefficient (D), on the model were simulated and analysed. One group of blood (ISF) glucose values was set as input for the model with one varied parameter and other fixed parameters to predict ISF (blood) glucose concentrations. The results verified that F and P have much influence on the model and others play more minor roles. And some have positive influence on the model, like P, while others have a reverse effect, like F. All parameters can be modulated for different species or different physiological status during the model application. |
| تدمد: | 1314-3530 1310-2818 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e663fc784d40e4f49f51a16bcce12dTest https://doi.org/10.1080/13102818.2017.1413595Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....64e663fc784d40e4f49f51a16bcce12d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13143530 13102818 |
|---|