B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma
| العنوان: | B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
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| المؤلفون: | Qiang Dong, Xinlong Ma |
| المصدر: | BioMed Research International BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Publishing Corporation, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, Pathology, Article Subject, Carcinogenesis, lcsh:Medicine, Kaplan-Meier Estimate, Biology, General Biochemistry, Genetics and Molecular Biology, Text mining, Internal medicine, Tumor stage, medicine, Biomarkers, Tumor, Humans, In patient, Clinical significance, Aged, Neoplasm Staging, Osteosarcoma, General Immunology and Microbiology, business.industry, lcsh:R, General Medicine, Middle Aged, V-Set Domain-Containing T-Cell Activation Inhibitor 1, medicine.disease, Prognosis, Gene Expression Regulation, Neoplastic, Normal bone, Tumor progression, Immunohistochemistry, Female, business, Research Article |
| الوصف: | Increasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis. However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear. The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS. B7-H4 expression in OS tissues was examined by immunohistochemistry. Soluble B7-H4 (sB7-H4) levels in blood were examined by ELISA. The association of B7-H4 expression with clinicopathological factors or prognosis was statistically analyzed. Our findings demonstrated that B7-H4 expression in OS tissues was significantly higher than those in paired normal bone tissues (P<0.001). sB7-H4 level in OS serum samples was significantly higher than that in healthy controls (P=0.005). High B7-H4 expression in tissues and sB7-H4 level were both correlated with advanced tumor stage (P<0.001,P=0.017, resp.) and distant metastasis (P=0.034,P=0.021, resp.). Additionally, high B7-H4 expression or serum sB7-H4 levels were significantly related to poor overall survival (P=0.028,P=0.005, resp.). B7-H4 in tissues and serum samples were an independent factor for affecting the survival time of OS patients (P=0.004,P=0.041, resp.). Collectively, our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfe171aa669a70c128941b7b856b896Test http://europepmc.org/articles/PMC4411454Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4cfe171aa669a70c128941b7b856b896 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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