المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.)

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://u-picardie.hal.science/hal-03374265Test
https://u-picardie.hal.science/hal-03374265/documentTest
https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, Metzinger-Le Meuth, Valérie, Metzinger, Laurent

المساهمون: Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord

المصدر: ISSN: 1661-6596.

مصطلحات موضوعية: endothelium dysfunction, syndecan-1, biomarker, chronic kidney disease, miR-126, microRNA, indoxyl sulfate, uremic toxins, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

الوصف: International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

العلاقة: hal-03374265; https://hal-u-picardie.archives-ouvertes.fr/hal-03374265Test; https://hal-u-picardie.archives-ouvertes.fr/hal-03374265/documentTest; https://hal-u-picardie.archives-ouvertes.fr/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

الإتاحة: https://doi.org/10.3390/ijms221910549Test
https://hal-u-picardie.archives-ouvertes.fr/hal-03374265Test
https://hal-u-picardie.archives-ouvertes.fr/hal-03374265/documentTest
https://hal-u-picardie.archives-ouvertes.fr/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest

المؤلفون: Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent

المساهمون: INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: International audience ; Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels

العلاقة: hal-02625556; https://hal.inrae.fr/hal-02625556Test; https://hal.inrae.fr/hal-02625556/documentTest; https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest; PRODINRA: 476212; WOS: 000461151800061

الإتاحة: https://doi.org/10.1038/s41598-019-41101-8Test
https://hal.inrae.fr/hal-02625556Test
https://hal.inrae.fr/hal-02625556/documentTest
https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest

المؤلفون: Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent

المساهمون: INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: International audience ; Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels

العلاقة: hal-02625556; https://hal.inrae.fr/hal-02625556Test; https://hal.inrae.fr/hal-02625556/documentTest; https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest; PRODINRA: 476212; WOS: 000461151800061

الإتاحة: https://doi.org/10.1038/s41598-019-41101-8Test
https://hal.inrae.fr/hal-02625556Test
https://hal.inrae.fr/hal-02625556/documentTest
https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest

المؤلفون: Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent

المساهمون: INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: International audience ; Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels

العلاقة: hal-02625556; https://hal.inrae.fr/hal-02625556Test; https://hal.inrae.fr/hal-02625556/documentTest; https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest; PRODINRA: 476212; WOS: 000461151800061

الإتاحة: https://doi.org/10.1038/s41598-019-41101-8Test
https://hal.inrae.fr/hal-02625556Test
https://hal.inrae.fr/hal-02625556/documentTest
https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest