Angiogenesis in the atherosclerotic plaque
| العنوان: | Angiogenesis in the atherosclerotic plaque |
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| المؤلفون: | Anne Nègre-Salvayre, Robert Salvayre, Mélanie Pucelle, Caroline Camaré |
| المساهمون: | Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Régulations cellulaires: lipidoses et atherosclerose, IFR 31 Louis Bugnard (IFR 31), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3) |
| المصدر: | Redox Biology Redox Biology, Elsevier, 2017, 12, pp.18-34. ⟨10.1016/j.redox.2017.01.007⟩ Redox Biology, Vol 12, Iss, Pp 18-34 (2017) |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Apolipoprotein E, SMC, smooth muscle cell, nNOS, neuronal nitric oxide synthase, RTKs, receptor tyrosine kinase, Review Article, Matrix metalloproteinase, Fibroblast growth factor, Biochemistry, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, RCT, reverse cholesterol transport, Medicine, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, ApoE, apolipoprotein E, ICAM-1, InterCellular Adhesion Molecule-1, Neovascularization, Pathologic, NADPH, H+, nicotinamide adenine dinucleotide phosphate, VCAM-1, Vascular Cell Adhesion Molecule-1, ABCG1, ATP-binding cassette sub-family G member 1, Plaque, Atherosclerotic, ECM, extracellular matrix, 3. Good health, S1PR, S1P receptors, FAK, focal adhesion kinase, S1P, sphingosine 1-phosphate, iNOS, inducible nitric oxide synthase, Disease Progression, lcsh:Medicine (General), ADMA, assymetric methylarginine, PI3K, phosphoinositide 3 kinase, Spns2, S1P carry spinster homolog 2, Hypercholesterolemia, PHD, prolyl hydroxylase, 03 medical and health sciences, TGF-β, transforming growth factor-β, PKC, protein kinase C, PUFA, polyunsaturated fatty acid, Humans, FGF, basic fibroblast growth factor, NRP-1, neuropilin-1, EGF, epidermal growth factor, NO, nitric oxide, SRC, Sarcoma tyrosine kinase, Cholesterol, TIMPs, Tissue Inhibitor of Metalloproteinases, Flt-1, fms-like tyrosine kinase-1, HDL, high density lipopoprotein, 030104 developmental biology, chemistry, NF-kB, nuclear factor kappaB, Immunology, FGFR, FGF receptor, Angiogenesis, PDGFR, PDGF receptor, 0301 basic medicine, [SDV]Life Sciences [q-bio], AC, adenylate cyclase, Clinical Biochemistry, Angiogenesis Inhibitors, 030204 cardiovascular system & hematology, PDGF, platelet-derived growth factor, LDLs, low density lipoproteins, TGFβR, TGF-β receptor, Neovascularization, chemistry.chemical_compound, HUVEC, human umbilical vein endothelial cell, ROCK, Rho associated protein kinase, LOX, lipoxygenase, nSMase2, neutral sphingomyelinase-2, APOE, human ApoE gene, Clinical Trials as Topic, lcsh:R5-920, SK1, sphingosine kinase −1, eNOS, endothelial nitric oxide synthase, VEGF, vascular endothelial growth factor, VEGF, MMP, matrix metalloproteinase, H2O2, hydrogen peroxide, Dll4, Delta-like-4, EGFR, EGF receptor, medicine.symptom, TLR, Toll-like receptor, Inflammation, HIF, Hypoxia inducible factor, ARNT, aryl hydrocarbon nuclear translocator, PLC, phospholipase C, ROS, reactive oxygen species, Animals, CPT1A, carnitine palmityl transferase, VCAM-1, PAI-1, plasminogen activator inhibitor 1, PPAR, peroxisome proliferator activated receptor, VEGFR, VEGF receptor, AIBP, ApoA-I binding protein, business.industry, TK, tyrosine kinase, Organic Chemistry, Apoe, animal ApoE gene, Atherosclerosis, ApoE−/− mice, homozygous ApoE-deficient mice, HSP, heparan sulfate proteoglycans, COX, cyclooxygenase, Oxidative Stress, lcsh:Biology (General), Cancer research, business, MAPK, mitogen activated protein kinase |
| الوصف: | Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries characterized by a local accumulation of cholesterol and non-resolving inflammation. Atherothrombotic complications are the leading cause of disability and mortality in western countries. Neovascularization in atherosclerotic lesions plays a major role in plaque growth and instability. The angiogenic process is mediated by classical angiogenic factors and by additional factors specific to atherosclerotic angiogenesis. In addition to its role in plaque progression, neovascularization may take part in plaque destabilization and thromboembolic events. Anti-angiogenic agents are effective to reduce atherosclerosis progression in various animal models. However, clinical trials with anti-angiogenic drugs, mainly anti-VEGF/VEGFR, used in anti-cancer therapy show cardiovascular adverse effects, and require additional investigations. Graphical abstract fx1 Highlights • Intimal neovascularization in plaque growth and destabilization. • Role of classical and specific angiogenic factors in atherosclerotic angiogenesis. • Inflammation and oxidative stress promote angiogenesis and plaque destabilization. • Angiogenesis promote intraplaque hemorrhages, afflux of blood cells and lipids. • Anti-angiogenic therapy for atherosclerotic angiogenesis. |
| اللغة: | English |
| تدمد: | 2213-2317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62a1d3f10ae17aeb4cf416d517cd170Test https://hal.archives-ouvertes.fr/hal-02349886Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d62a1d3f10ae17aeb4cf416d517cd170 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132317 |
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