Liver transplantation in patients with sickle cell disease: possible but challenging—a cohort study
| العنوان: | Liver transplantation in patients with sickle cell disease: possible but challenging—a cohort study |
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| المؤلفون: | Christophe Duvoux, Eric Levesque, Francesco Esposito, Pablo Bartolucci, Cyrille Feray, Daniel Cherqui, Daniel Azoulay, Anoosha Habibi, Benoit Robin, Chetana Lim, Chady Salloum, Anne-Laure Quere, Frédéric Galactéros, Jean-Claude Merle |
| المصدر: | Transplant International. 33:1220-1229 |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, medicine.medical_treatment, Cell, Anemia, Sickle Cell, Disease, 030230 surgery, Liver transplantation, Gastroenterology, law.invention, Cohort Studies, End Stage Liver Disease, 03 medical and health sciences, Liver disease, 0302 clinical medicine, law, Internal medicine, medicine, Humans, Renal replacement therapy, Retrospective Studies, Mechanical ventilation, Transplantation, business.industry, medicine.disease, Intensive care unit, Liver Transplantation, Treatment Outcome, medicine.anatomical_structure, 030211 gastroenterology & hepatology, business, Cohort study |
| الوصف: | The liver is frequently affected in patients with sickle cell disease (SCD), but few reports have described liver transplantation (LT) in patients with SCD. We present a thorough analysis of the largest single-center series of LT in patients with SCD and the first systematic review. There were 21 patients with a median age of 37.6 years. LT was performed for acute liver failure related to the sickling process (57%) or electively for end-stage liver disease (43%). Prior to LT, 13 patients (62%) were in the intensive care unit and required mechanical ventilation (33%), vasopressor therapy (24%), renal replacement therapy (10%), or molecular adsorbent recirculating system therapy (19%). Post-LT morbidity and mortality were 95% and 33%, respectively. Patient survival at 1 and 5 years were 58.3% and 41.7%, respectively, in the urgent group and 88.9% and 77.8%, respectively, in the elective group. A total of 22 transplant patients with SCD are described in 20 articles in the literature. The 1- and 5-year patient survival rates for the 18 evaluable patients were 75% and 65%, respectively. LT improves survival in patients with SCD and acute liver failure or end-stage liver disease but is associated with high morbidity during the early postoperative course. |
| تدمد: | 1432-2277 0934-0874 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b72712bfcb82989fa7a5d2138798dcdTest https://doi.org/10.1111/tri.13669Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8b72712bfcb82989fa7a5d2138798dcd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322277 09340874 |
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