المؤلفون: Brett, A, Bowes, MA, Conaghan, PG, Ladel, C, Guehring, H, Moreau, F, Eckstein, F

الوصف: Background Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug. Previously, 2-year results from the FORWARD study showed significant dose-dependent modification of cartilage thickness in the total femorotibial joint (TFTJ), medial and lateral femorotibial compartments (MFTC, LFTC), and central medial and lateral TFTJ subregions, by quantitative magnetic resonance imaging (qMRI) using manual segmentation. Objective To determine whether qMRI findings from FORWARD could be reproduced by an independent method of automated segmentation using an identical dataset and similar anatomical regions in a post-hoc analysis. Method Cartilage thickness was assessed at baseline and 6, 12, 18 and 24 months, using automated cartilage segmentation with active appearance models, a supervised machine learning method. Images were blinded for treatment and timepoint. Treatment effect was assessed by observed and adjusted changes using a linear mixed model for repeated measures. Results Based on automated segmentation, statistically significant, dose-dependent structural modification of cartilage thickness was observed over 2 years with sprifermin vs placebo for TFTJ (overall treatment effect and dose response, both P < 0.001), MFTC (P = 0.004 and P = 0.044), and LFTC (both P < 0.001) regions. For highest dose, in the central medial tibial (P = 0.008), central lateral tibial (P < 0.001) and central lateral femoral (P < 0.001) regions. Conclusions Cartilage thickness assessed by automated segmentation provided a consistent dose response in structural modification compared with manual segmentation. This is the first time that two independent quantification methods of image analysis have reached the same conclusions in an interventional trial, strengthening the conclusions that sprifermin modifies structural progression in knee osteoarthritis.

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/165065/8/2019%20OC%20FWD%20cartilage%20analysis%20final%20with%20changes.pdfTest; Brett, A, Bowes, MA, Conaghan, PG orcid.org/0000-0002-3478-5665 et al. (4 more authors) (2020) Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study. Osteoarthritis and Cartilage. ISSN 1063-4584

الإتاحة: https://eprints.whiterose.ac.uk/165065Test/
https://eprints.whiterose.ac.uk/165065/8/2019%20OC%20FWD%20cartilage%20analysis%20final%20with%20changes.pdfTest

المؤلفون: Pinheiro, M, Strand, V, Alten, R, Conaghan, PG, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Deodhar, A

المصدر: Value in Health ; volume 20, issue 9, page A901 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2767Test
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المؤلفون: Azevedo, VF, Conaghan, PG, Strand, V, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Alten, R

المصدر: Value in Health ; volume 20, issue 9, page A901 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2768Test
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المؤلفون: Scheinberg, M, Conaghan, PG, Alten, R, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Strand, V

المصدر: Value in Health ; volume 20, issue 9, page A903 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2712Test
https://api.elsevier.com/content/article/PII:S1098301517330462?httpAccept=text/xmlTest
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المؤلفون: Pereira, I, Alten, R, Conaghan, PG, Strand, V, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Deodhar, A

المصدر: Value in Health ; volume 20, issue 9, page A903 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2711Test
https://api.elsevier.com/content/article/PII:S1098301517330450?httpAccept=text/xmlTest
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المؤلفون: Deodhar, A, Conaghan, PG, Alten, R, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Strand, V

المصدر: Value in Health ; volume 20, issue 9, page A903 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2713Test
https://api.elsevier.com/content/article/PII:S1098301517330474?httpAccept=text/xmlTest
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المؤلفون: Ranza, R, Alten, R, Strand, V, Sullivan, E, Blackburn, S, Tian, H, Gandhi, K, Jugl, SM, Conaghan, PG

المصدر: Value in Health ; volume 20, issue 9, page A903 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2017.08.2710Test
https://api.elsevier.com/content/article/PII:S1098301517330449?httpAccept=text/xmlTest
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المؤلفون: Mathur, A, Driban, JB, McAlindon, TE, Guillemin, F, Neogi, T, Kwoh, C, Mobasheri, A, Nevitt, MC, Conaghan, PG, Wise, BL, Zhang, Y, Hunter, DJ, Huxham, L, Scotti, C

المصدر: Osteoarthritis and Cartilage. 30:S200-S201

مصطلحات موضوعية: Rheumatology, Clinical Sciences, Biomedical Engineering, Orthopedics and Sports Medicine, Human Movement and Sports Sciences, Arthritis & Rheumatology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2523f0e36e4c2052d6609a499cbfb93Test
https://doi.org/10.1016/j.joca.2022.02.267Test

المؤلفون: Watt, FE, Corp, N, Kingsbury, SR, Frobell, R, Englund, M, Felson, DT, Levesque, M, Majumdar, S, Wilson, C, Beard, DJ, Lohmander, LS, Kraus, VB, Roemer, F, Conaghan, PG, Mason, DJ, Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group

مصطلحات موضوعية: Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group

الوصف: OBJECTIVE:There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points to consider for the design and conduct of interventional studies following acute knee injury. DESIGN:An evidence review on acute knee injury interventional studies to prevent PTOA was presented to the group, alongside overviews of challenges in this area, including potential targets, biomarkers and imaging. Working groups considered pre-identified key areas: eligibility criteria and outcomes, biomarkers, injury definition and intervention timing including multi-modality interventions. Consensus agreement within the group on points to consider was generated and is reported here after iterative review by all contributors. RESULTS:The evidence review identified 37 studies. Study duration and outcomes varied widely and 70% examined surgical interventions. Considerations were grouped into three areas: justification of inclusion criteria including the classification of injury and participant age (as people over 35 may have pre-existing OA); careful consideration in the selection and timing of outcomes or biomarkers; definition of the intervention(s)/comparator(s) and the appropriate time-window for intervention (considerations may be particular to intervention type). Areas for further research included demonstrating the utility of patient-reported outcomes, biomarkers and imaging outcomes from ancillary/cohort studies in this area, and development of surrogate clinical trial endpoints that shorten the duration of clinical trials and are acceptable to regulatory agencies. CONCLUSIONS:These considerations represent the first international consensus on the conduct of interventional studies following acute knee joint trauma.

وصف الملف: application/pdf

العلاقة: Osteoarthritis and cartilage; S1063-4584(18)31412-2; https://hdl.handle.net/10161/18043Test

الإتاحة: https://hdl.handle.net/10161/18043Test

المؤلفون: Conaghan, PG, Brooks, P

مصطلحات موضوعية: musculoskeletal diseases, RHEUMATOID-ARTHRITIS, 11 Medical and Health Sciences, 1103 Clinical Sciences

الوصف: Musculoskeletal conditions are becoming more prevalent in the aging and increasingly overweight Western population. Many such conditions are chronic, and most people concerned have problems with more than one anatomical joint region, resulting in cumulatively increased problems with performing daily tasks. Management is complex because of the chronic nature of many of these conditions, the need for regular assessment of disease impact, the individual's responses to the disease and its treatment, the presence of co-morbidities, and the lack of well-designed studies of long-term outcome to guide treatment. There are significant issues about how to monitor outcomes in routine practice, and many outcome measures have been developed for use in clinical trials. Principles of modern management include involvement of people in their own care, early intervention, and the need to consider a multidisciplinary approach. Most conditions will require combinations of one or more non-pharmacological therapies (especially muscle strengthening and aerobic exercise) and pharmacological agents, with attention given to appropriate timing of surgical interventions.

الإتاحة: https://doi.org/10.1016/j.berh.2008.02.004Test
https://espace.library.uq.edu.au/view/UQ:182731Test