المؤلفون: Sujit Mukherjee, Evangelos Triantafyllou, Oltin T Pop, Fabien Zoulim, Enes Tunc, Alberto Quaglia, Arjuna Singanayagam, Wafa Khamri, Mark Thursz, Tie Zheng Hou, Fanny Lebossé, Julia Wendon, Rooshi Nathwani, Charalambos G. Antoniades, Cathrin Gudd, Naveenta Kumar, A. Dhar

المساهمون: Imperial College London, King‘s College London, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University College of London [London] (UCL), Manship, Brigitte, BRC ITMAT Funding Scheme, Medical Research Council

المصدر: EBioMedicine
EBioMedicine, 2019, 49, pp.258-268. ⟨10.1016/j.ebiom.2019.10.011⟩

مصطلحات موضوعية: CHRONIC LIVER-FAILURE, 0301 basic medicine, Liver Cirrhosis, Male, Cirrhosis, Research paper, Transcription, Genetic, Apoptosis, Research & Experimental Medicine, CD8-Positive T-Lymphocytes, Chronic liver disease, Severity of Illness Index, 0302 clinical medicine, INFECTION, Ascites, Cytotoxic T cell, Myeloid Cells, CD8(+)T cells, ALD, alcohol-related liver disease, NEUTROPHILS, CD8(+) T cells, medicine.diagnostic_test, ACLF, acute-on-chronic-liver disease, General Medicine, Middle Aged, 3. Good health, CD8+T cells, Phenotype, Treatment Outcome, Medicine, Research & Experimental, 030220 oncology & carcinogenesis, SURVIVAL, CLD, Chronic liver disease, Female, Disease Susceptibility, medicine.symptom, Peritoneum, Life Sciences & Biomedicine, EXPRESSION, CAID, cirrhosis-associated immune dysfunction, NASH, non-alcoholic steatohepatitis, Cirrhosis-associated immune dysfunction, [SDV.CAN]Life Sciences [q-bio]/Cancer, AAH, acute alcoholic hepatitis, Peripheral blood mononuclear cell, General Biochemistry, Genetics and Molecular Biology, Flow cytometry, 03 medical and health sciences, Medicine, General & Internal, Immune system, [SDV.CAN] Life Sciences [q-bio]/Cancer, General & Internal Medicine, medicine, HV, Healthy volunteers, Humans, Aged, Cell Proliferation, Inflammation, Science & Technology, business.industry, ELD, End-stage-liver diseases, HLA-DR Antigens, medicine.disease, AD, acute decompensation, 030104 developmental biology, Immunology, Natural Killer T-Cells, business, CD8, Biomarkers, PMNs, polymorphonuclear neutrophils

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9318081e284f95b31ce34f205764d8dbTest
http://europepmc.org/articles/PMC6945243Test

المؤلفون: Ik Hwan Kim, Moon Kee Meang, Young Min Yoon, Ji Yong Lee, Byung Soo Youn, Tae Hee Lee, Han-Soo Kim, Lee Ji Eun, Yae Eun Park

المصدر: EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, Research paper, Eupatilin, CD, chromone scaffold derivative, Stem cells, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, Fibrosis, Chromone scaffold, Transforming Growth Factor beta, Phosphorylation, Myofibroblasts, DHLF, diseased human lung fibroblast, Epithelial–mesenchymal transition, Cell Differentiation, General Medicine, Pirfenidone, Extracellular Matrix, 030220 oncology & carcinogenesis, Nintedanib, Dedifferentiation, Myofibroblast, medicine.drug, NASH, non-alcoholic steatohepatitis, BLM, bleomycin-induced lung fibrosis model, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Bleomycin, In vivo, medicine, Hepatic Stellate Cells, IPF, idiopathic pulmonary fibrosis, Animals, Humans, Smad3 Protein, Flavonoids, business.industry, Fibroblasts, medicine.disease, CS, chromone scaffold, Disease Models, Animal, 030104 developmental biology, chemistry, Gene Expression Regulation, Latent TGF-beta Binding Proteins, Cell Transdifferentiation, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51eade2f05c6a25366163c9dcd9de8Test
http://europepmc.org/articles/PMC6355727Test

المؤلفون: Adam J. Rauckhorst, Xiaorong Fu, Katherine N. Gibson-Corley, Alvin D. Pewa, Ryan D. Sheldon, Eric B. Taylor, James E. Cox, Charlotte R. Feddersen, Shawn C. Burgess, Adam J. Dupuy, Lawrence R. Gray

المصدر: Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, Mitochondria, Liver, Mitochondrion, Mitochondrial Membrane Transport Proteins, Mice, 0302 clinical medicine, HFD, high fat diet, Fibrosis, immune system diseases, Pyruvic Acid, digestive, oral, and skin physiology, Diabetes, Mitochondria, HOMA-IR, homeostatic model assessment of insulin resistance, medicine.anatomical_structure, Liver, Mitochondrial matrix, 030220 oncology & carcinogenesis, Hepatocyte, Original Article, MPC, mitochondrial pyruvate carrier, TCA, tricarboxylic acid cycle, Monocarboxylic Acid Transporters, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, NASH, non-alcoholic steatohepatitis, Anion Transport Proteins, Citric Acid Cycle, T2D, type 2 diabetes, Biology, Diet, High-Fat, Mitochondrial pyruvate carrier (MPC), 03 medical and health sciences, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, ITT, insulin tolerance test, Inflammation, NCD, normal chow diet, Gluconeogenesis, Membrane Transport Proteins, nutritional and metabolic diseases, Cell Biology, Metabolism, medicine.disease, Citric acid cycle, Disease Models, Animal, Cytosol, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, Hepatocytes, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80260421dd9726225c6f9a3cac3cf9faTest
http://www.sciencedirect.com/science/article/pii/S2212877817306828Test

المؤلفون: Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Hiromine Yasukawa, Masaaki Komatsu, Arisa Negishi, Masaki Kobayashi, Ayana Hoshino, Daiki Natori, Shukoh Watanabe, Yoshikazu Higami

المصدر: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 115-124 (2018)

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Cellular homeostasis, medicine.disease_cause, Biochemistry, Autophagy-Related Protein 5, chemistry.chemical_compound, Mice, 0302 clinical medicine, HFD, high fat diet, NAD(P)H Dehydrogenase (Quinone), shRNA, small hairpin RNA, lcsh:QH301-705.5, Ho-1, heme oxygenase-1, GFP, green fluorescent protein, chemistry.chemical_classification, Mice, Knockout, Proto-Oncogene Proteins c-yes, lcsh:R5-920, Kelch-Like ECH-Associated Protein 1, mTOR, mechanistic target of rapamycin, TOR Serine-Threonine Kinases, p62, Cell biology, Keap1, Kelch-like ECH-associated protein 1, 030220 oncology & carcinogenesis, RFP, red fluorescent protein, ROS, reactive oxygen species, MCP1, monocyte chemoattractant protein-1, Antioxidant, lcsh:Medicine (General), LC3, microtubule-associated protein 1 light chain 3 (MAP1LC3), Nicotinamide adenine dinucleotide phosphate, Research Paper, Signal Transduction, NAFLD, non-alcoholic fatty liver disease, NF-E2-Related Factor 2, NASH, non-alcoholic steatohepatitis, Biology, DMEM, Dulbecco's Modified Eagle Medium, Keap1–Nrf2 system, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, Nqo1, nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1, ATG, autophagy-related gene, medicine, Autophagy, Animals, Humans, Nrf2, nuclear factor (erythroid-derived 2)-like 2, PI3K/AKT/mTOR pathway, Reactive oxygen species, Organic Chemistry, Trehalose, Membrane Proteins, KEAP1, MEF, mouse embryonic fibroblast, Oxidative Stress, 030104 developmental biology, chemistry, lcsh:Biology (General), Oxidative stress, Heme Oxygenase-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20769cb875708e64386013f26c149eb6Test
http://europepmc.org/articles/PMC5730428Test